The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
960
3D
1qxpB02 - 97.3
6
619
3D
5qc4B00 - 90.4
2
612 - - 71.3
3
582
3D
5k16B00 - 74.7
4
503 - - 80.0
5
414 - - 84.8
7
367 - - 75.9
8
355 - - 72.2
9
354
3D
2vhfB00 - 86.0
10
351 - - 92.6
13
326
3D
6ml1B00 - 62.3
11
317 - - 72.4
12
315 - - 43.5
14
286 - - 69.6
15
273 - - 76.3
16
268 - - 81.9
17
252 - - 85.5
31
251
3D
6ay2B00 - 94.1
18
251 - - 72.9
19
231 - - 73.7
21
231
3D
2cb5B01 - 91.9
20
230 - - 47.1
24
222
3D
6dgfA00 - 77.0
23
219
3D
1s4vB00 - 90.9
22
218 - - 93.1
25
210
3D
3n3kA00 - 77.9
26
206 - - 89.0
27
204 - - 83.0
28
203 - - 73.9
29
198 - - 77.9
30
197 - - 71.2
32
196
3D
6iinB00 - 89.8
33
175
3D
3ihpB03 - 67.3
34
167 - - 50.6
36
160
3D
3ch3X00 - 75.7
35
159 - - 76.4
37
150 - - 79.6
38
146 - - 78.0
39
144 - - 95.4
40
142 - - 59.7
41
137 - - 84.2
43
131 - - 89.9
42
131 - - 74.9
44
130 - - 82.9
45
125 - - 76.9
46
115 - - 86.8
47
115 - - 70.4
48
113 - - 79.1
49
111 - - 87.8
50
110
3D
1m6dB00 - 72.5
51
101 - - 42.9
52
98 - - 54.6
58
97
3D
3mtnC00 - 76.4
53
96 - - 69.6
54
95 - - 93.4
55
94 - - 84.9
57
90 - - 89.7
60
90
3D
1ef7B00 - 84.0
56
90 - - 73.0
138
87
3D
6exqB00 - 91.8
59
87 - - 70.9
61
85 - - 44.4
62
84
3D
3pdfA02 - 72.6
64
81 - - 87.0
63
81 - - 77.4
65
80 - - 50.8
66
79 - - 79.3
67
77 - - 89.4
68
76 - - 76.0
69
76 - - 26.1
70
74 - - 80.3
71
71 - - 51.1
72
70 - - 75.7
74
67
3D
6czsA00 - 72.5
86
67
3D
2oulA00 - 37.6
73
66 - - 80.4
75
65 - - 67.9
76
64 - - 53.9
77
63 - - 60.4
78
62 - - 69.6
79
59 - - 82.9
80
58 - - 72.4
81
56 - - 90.3
82
55 - - 36.4
91
53
3D
3gcbA01 - 83.5
84
52 - - 74.8
83
52 - - 83.7
85
51 - - 69.2
96
50
3D
4n4zA00 - 94.1
87
50 - - 85.6
88
50
3D
5chvB00 - 73.1
204
48
3D
9papA00 - 86.2
89
45 - - 77.9
90
44 - - 94.6
92
43 - - 89.0
94
42 - - 35.3
95
42 - - 71.6
93
42 - - 71.6
97
40 - - 31.0
99
38 - - 85.3
98
Pcalp
38 - - 27.0
101
36 - - 71.1
100
36 - - 77.1
102
35 - - 80.4
103
35 - - 93.6
105
34 - - 72.5
106
34 - - 51.6
104
34 - - 94.7
108
33 - - 83.2
109
33 - - 94.8
107
33 - - 3.8
110
31 - - 61.5
111
30 - - 28.0
168
30
3D
6r9qA01 - 65.1
112
29 - - 71.7
113
29 - - 75.2
114
29 - - 97.5
115
28 - - 72.2
126
28
3D
6ffaA00 - 25.3
190
28
3D
6aqrA02 - 17.4
116
27 - - 86.3
117
27 - - 87.4
119
26 - - 81.3
118
26 - - 64.6
120
25 - - 28.1
121
25 - - 72.5
122
25 - - 86.3
127
24 - - 75.7
128
24 - - 79.7
129
24 - - 88.6
124
24 - - 65.0
130
24 - - 84.8
125
24 - - 47.8
123
24 - - 40.1
131
23 - - 79.4
132
22 - - 63.1
133
22 - - 58.8
134
22 - - 73.7
136
21 - - 72.3
137
21 - - 13.9
135
21 - - 69.0
139
20 - - 7.6
140
19 - - 66.2
142
18 - - 74.2
148
18
3D
3zuaA01 - 42.2
141
18 - - 17.7
147
17 - - 11.7
149
17 - - 7.2
145
17 - - 84.0
555
17
3D
6bkjD02 - 51.7
146
17 - - 64.8
144
17 - - 74.6
156
17
3D
1vjvA01 - 85.6
150
17 - - 93.8
143
17 - - 86.9
153
16 - - 26.6
155
16 - - 77.9
154
16 - - 6.8
152
16 - - 75.2
151
16 - - 12.2
158
15 - - 81.8
161
15 - - 76.0
157
15 - - 18.4
160
15 - - 10.1
159
15 - - 69.6
165
14 - - 76.6
164
14 - - 68.2
167
14 - - 96.0
163
14 - - 82.3
162
14 - - 64.5
166
14 - - 62.8
170
13 - - 2.8
175
13 - - 30.4
174
13 - - 70.8
177
13 - - 84.3
173
13 - - 21.8
171
13 - - 85.5
176
13 - - 70.4
169
13 - - 9.0
172
13 - - 93.2
180
12 - - 64.5
178
12 - - 78.4
179
12 - - 11.7
191
Human disease gene
11 - - 40.6
187
11 - - 10.8
184
11 - - 27.0
181
11 - - 13.5
188
11 - - 14.8
183
11 - - 18.2
189
11 - - 73.4
182
11 - - 17.0
186
11 - - 12.4
185
11 - - 33.8
207
10 - - 74.2
198
10 - - 74.4
202
10 - - 70.2
200
10 - - 17.0
192
10 - - 60.3
199
10 - - 71.8
195
10 - - 72.9
203
10 - - 35.2
193
10 - - 31.7
205
10 - - 62.8
196
10 - - 88.0
206
10 - - 67.3
194
10 - - 59.0
197
10 - - 33.9
208
10 - - 77.0
201
10 - - 12.3
216
10
3D
4msxA02 - 2.1
212
9 - - 69.9
217
9 - - 19.3
209
9 - - 39.0
210
9 - - 15.6
408
9
3D
1o0eB00 - 58.6
213
9 - - 22.6
211
9 - - 89.7
218
9 - - 80.5
214
9 - - 19.5
219
9 - - 96.5
215
9 - - 1.1
232
8 - - 82.3
225
8 - - 8.8
229
8 - - 8.9
222
8 - - 59.4
224
8 - - 34.1
228
8 - - 13.7
221
8 - - 79.6
227
8 - - 29.6
230
8 - - 34.9
220
8 - - 53.0
226
8 - - 10.9
231
8 - - 77.9
223
8 - - 12.6
246
7 - - 6.2
257
7 - - 67.7
247
7 - - 8.0
252
7 - - 9.0
242
7 - - 79.6
254
7 - - 1.9
233
7 - - 17.6
243
7 - - 64.2
238
7 - - 13.7
253
7 - - 6.5
258
7 - - 45.3
248
7 - - 10.2
236
7 - - 4.0
234
7 - - 69.4
255
7 - - 0.0
250
7 - - 8.4
249
7 - - 2.1
240
7 - - 0.0
239
7 - - 5.9
244
7 - - 7.4
237
7 - - 5.9
235
7 - - 67.5
251
7 - - 10.7
256
7 - - 46.0
245
7 - - 10.0
241
7 - - 72.3
272
6 - - 3.1
262
6 - - 86.2
278
6 - - 18.4
281
6 - - 2.6
284
6 - - 85.8
271
6 - - 9.1
279
6 - - 4.6
263
6 - - 0.0
267
6 - - 88.2
280
6 - - 0.0
273
6 - - 2.5
268
6 - - 3.8
260
6 - - 72.3
264
6 - - 38.0
274
6 - - 5.7
276
6 - - 53.6
259
6 - - 73.4
269
6 - - 3.7
283
6 - - 5.7
265
6 - - 74.9
275
6 - - 0.4
332
6
3D
1cs8A00 - 48.4
270
6 - - 8.0
266
6 - - 70.5
261
6 - - 83.2
282
6 - - 8.3
277
6 - - 5.9
311
5 - - 0.0
285
5 - - 2.4
308
5 - - 6.7
301
5 - - 55.1
294
5 - - 3.4
307
5 - - 0.0
299
5 - - 47.0
315
5 - - 68.2
305
5 - - 11.1
317
5 - - 41.8
289
5 - - 75.4
319
5 - - 75.1
290
5 - - 74.4
309
5 - - 0.0
293
5 - - 6.1
310
5 - - 16.8
316
5 - - 39.2
314
5 - - 16.2
302
5 - - 2.9
298
5 - - 6.4
318
5 - - 58.2
288
5 - - 76.7
287
5 - - 19.2
303
5 - - 9.8
320
5 - - 57.7
313
5 - - 0.0
297
5 - - 9.3
295
5 - - 2.3
312
5 - - 8.9
300
5 - - 36.3
286
5 - - 5.7
296
5 - - 4.3
292
5 - - 72.3
291
5 - - 73.4
321
5 - - 69.0
304
5 - - 4.0
306
5 - - 34.1
350
4 - - 38.0
340
4 - - 0.0
349
4 - - 33.1
323
4 - - 8.2
330
4 - - 58.7
353
4 - - 60.0
326
4 - - 59.7
335
4 - - 64.9
344
4 - - 72.7
336
4 - - 28.6
351
4 - - 30.8
342
4 - - 4.6
341
4 - - 9.8
329
4 - - 57.0
346
4 - - 12.6
322
4 - - 8.1
354
4 - - 68.4
355
4 - - 69.0
334
4 - - 59.7
339
4 - - 56.5
345
4 - - 66.3
356
4 - - 66.7
325
4 - - 17.7
337
4 - - 62.6
333
4 - - 49.2
347
4 - - 7.9
338
4 - - 49.1
328
4 - - 58.4
357
4 - - 57.4
331
4 - - 67.4
358
4 - - 74.2
348
4 - - 1.2
324
4 - - 0.0
352
4 - - 41.5
327
4 - - 38.9
343
4 - - 0.0
391
3 - - 73.4
366
3 - - 8.2
413
3 - - 68.6
359
3 - - 19.1
360
3 - - 42.8
375
3 - - 72.0
387
3 - - 8.9
395
3 - - 3.0
361
3 - - 11.9
412
3 - - 61.1
383
3 - - 47.2
419
3 - - 73.3
406
3 - - 43.8
365
3 - - 0.0
382
3 - - 43.9
367
3 - - 6.4
405
3 - - 40.2
392
3 - - 71.4
399
3 - - 0.0
386
3 - - 7.4
372
3 - - 42.2
414
3 - - 71.7
402
3 - - 7.4
362
3 - - 0.8
407
3 - - 26.7
376
3 - - 72.5
371
3 - - 3.9
396
3 - - 5.2
378
3 - - 12.9
389
3 - - 0.0
410
3 - - 56.7
415
3 - - 75.8
417
3 - - 23.1
381
3 - - 46.4
373
3 - - 63.4
400
3 - - 0.0
393
3 - - 0.0
385
3 - - 0.5
377
3 - - 73.1
363
3 - - 0.0
397
3 - - 9.1
401
3 - - 56.1
404
3 - - 8.2
390
3 - - 11.3
418
AFU_orthologue AFUA_2G08440
3 - - 41.2
364
3 - - 1.1
388
3 - - 3.4
379
3 - - 12.4
370
3 - - 4.2
416
3 - - 38.0
380
3 - - 22.9
369
3 - - 0.8
394
3 - - 9.2
368
3 - - 10.4
374
3 - - 12.5
409
3 - - 44.7
411
3 - - 66.7
398
3 - - 2.2
384
3 - - 29.9
420
3 - - 29.6
403
3 - - 13.1
512
2 - - 39.3
463
2 - - 37.0
517
2 - - 9.6
458
2 - - 12.9
495
AFU_orthologue AFUA_1G07555
2 - - 0.0
486
2 - - 2.0
536
2 - - 20.9
444
2 - - 0.0
508
2 - - 0.0
558
2 - - 37.2
506
2 - - 4.0
456
2 - - 20.4
468
2 - - 34.8
432
2 - - 39.6
545
2 - - 32.6
542
2 - - 0.0
566
2 - - 39.3
526
2 - - 1.4
477
2 - - 8.8
449
2 - - 6.2
501
2 - - 0.0
490
2 - - 1.8
461
2 - - 34.2
425
2 - - 0.0
539
2 - - 0.0
520
AFU_orthologue AFUA_2G08440
2 - - 0.0
532
2 - - 37.4
554
2 - - 40.1
552
2 - - 35.7
440
2 - - 0.0
467
2 - - 38.6
481
2 - - 0.0
474
2 - - 17.6
563
2 - - 34.4
472
2 - - 12.2
546
2 - - 31.0
537
2 - - 38.1
529
2 - - 6.2
457
2 - - 32.1
505
AFU_orthologue AFUA_5G13620
2 - - 0.0
421
2 - - 14.8
491
2 - - 0.0
559
2 - - 41.2
443
2 - - 8.9
431
2 - - 36.4
509
2 - - 36.6
523
2 - - 0.0
453
2 - - 0.0
488
2 - - 11.3
507
2 - - 2.2
436
2 - - 3.0
525
2 - - 6.9
427
2 - - 31.9
426
2 - - 21.8
498
2 - - 8.7
483
2 - - 1.8
533
2 - - 1.9
462
2 - - 38.5
476
2 - - 10.2
469
2 - - 40.6
543
2 - - 38.7
565
2 - - 44.8
511
2 - - 40.6
471
2 - - 36.7
502
2 - - 5.5
553
2 - - 34.9
423
2 - - 22.5
422
2 - - 0.0
464
2 - - 40.8
562
2 - - 41.0
439
2 - - 2.5
435
2 - - 0.6
494
2 - - 4.6
487
2 - - 10.0
448
2 - - 0.0
547
2 - - 32.3
482
2 - - 4.8
499
2 - - 7.3
450
2 - - 0.0
473
2 - - 37.5
528
2 - - 0.0
560
2 - - 39.0
451
2 - - 0.0
454
2 - - 0.0
540
2 - - 0.0
430
2 - - 36.4
447
2 - - 10.6
480
2 - - 27.9
438
2 - - 3.1
493
2 - - 1.5
534
2 - - 13.1
475
2 - - 17.0
515
2 - - 28.8
519
2 - - 9.3
446
2 - - 0.0
556
2 - - 35.0
510
2 - - 34.9
549
2 - - 39.7
424
2 - - 0.0
434
2 - - 36.5
442
2 - - 0.0
465
2 - - 42.2
479
2 - - 27.3
524
2 - - 11.7
564
2 - - 43.5
503
2 - - 7.6
484
2 - - 5.8
544
2 - - 23.2
522
2 - - 2.3
459
2 - - 34.3
516
2 - - 31.3
561
2 - - 42.3
455
2 - - 1.9
550
2 - - 35.6
530
2 - - 8.9
470
2 - - 41.1
437
2 - - 0.5
527
2 - - 13.3
548
2 - - 32.3
485
2 - - 0.5
460
2 - - 36.1
452
2 - - 0.0
535
2 - - 18.4
541
2 - - 0.7
496
2 - - 0.0
445
2 - - 0.0
557
2 - - 20.2
441
2 - - 0.0
428
2 - - 31.9
500
2 - - 0.0
514
2 - - 49.2
513
2 - - 40.8
492
2 - - 11.6
429
2 - - 29.1
489
2 - - 0.8
538
2 - - 28.0
521
2 - - 0.0
433
2 - - 42.4
518
2 - - 10.9
497
2 - - 2.2
478
2 - - 26.5
551
2 - - 34.6
504
2 - - 0.0
531
2 - - 0.0
466
2 - - 39.6
722
1 - - 0.0
728
1 - - 0.0
742
1 - - 0.0
825
1 - - 0.0
834
1 - - 0.0
569
1 - - 0.0
686
1 - - 0.0
690
1 - - 0.0
573
1 - - 0.0
638
1 - - 0.0
875
1 - - 0.0
661
1 - - 0.0
581
1 - - 0.0
678
1 - - 0.0
652
1 - - 0.0
796
1 - - 0.0
844
1 - - 0.0
775
1 - - 0.0
888
1 - - 0.0
700
1 - - 0.0
764
1 - - 0.0
606
1 - - 0.0
666
1 - - 0.0
860
1 - - 0.0
708
1 - - 0.0
710
1 - - 0.0
856
1 - - 0.0
588
1 - - 0.0
756
1 - - 0.0
574
1 - - 0.0
660
1 - - 0.0
604
1 - - 0.0
766
1 - - 0.0
659
1 - - 0.0
682
1 - - 0.0
788
1 - - 0.0
626
1 - - 0.0
782
1 - - 0.0
809
1 - - 0.0
736
1 - - 0.0
781
1 - - 0.0
872
1 - - 0.0
584
1 - - 0.0
665
1 - - 0.0
904
1 - - 0.0
649
1 - - 0.0
648
1 - - 0.0
642
1 - - 0.0
776
1 - - 0.0
830
1 - - 0.0
704
1 - - 0.0
681
1 - - 0.0
890
1 - - 0.0
841
1 - - 0.0
867
1 - - 0.0
817
1 - - 0.0
673
1 - - 0.0
748
1 - - 0.0
711
1 - - 0.0
892
1 - - 0.0
741
1 - - 0.0
908
1 - - 0.0
903
1 - - 0.0
729
1 - - 0.0
808
1 - - 0.0
845
1 - - 0.0
735
1 - - 0.0
636
1 - - 0.0
600
1 - - 0.0
821
1 - - 0.0
696
1 - - 0.0
670
1 - - 0.0
837
1 - - 0.0
625
1 - - 0.0
712
1 - - 0.0
763
1 - - 0.0
570
1 - - 0.0
883
1 - - 0.0
655
1 - - 0.0
840
1 - - 0.0
597
1 - - 0.0
580
1 - - 0.0
846
1 - - 0.0
675
1 - - 0.0
859
1 - - 0.0
739
1 - - 0.0
876
1 - - 0.0
662
1 - - 0.0
772
1 - - 0.0
653
1 - - 0.0
716
1 - - 0.0
685
1 - - 0.0
743
1 - - 0.0
723
1 - - 0.0
595
1 - - 0.0
835
1 - - 0.0
901
1 - - 0.0
862
1 - - 0.0
881
1 - - 0.0
824
1 - - 0.0
813
1 - - 0.0
644
1 - - 0.0
851
1 - - 0.0
568
1 - - 0.0
791
1 - - 0.0
787
1 - - 0.0
769
1 - - 0.0
803
1 - - 0.0
691
1 - - 0.0
650
1 - - 0.0
895
1 - - 0.0
629
1 - - 0.0
869
1 - - 0.0
790
1 - - 0.0
615
1 - - 0.0
635
1 - - 0.0
575
1 - - 0.0
709
1 - - 0.0
699
1 - - 0.0
818
1 - - 0.0
757
1 - - 0.0
603
1 - - 0.0
850
1 - - 0.0
891
1 - - 0.0
842
1 - - 0.0
899
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