CATH Domain 6ay2B00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family	Cathepsin B

Enzyme Information

3.4.22.1

Cathepsin B.

based on mapping to UniProt P07858

Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.

-!- An intracellular (lysosomal) enzyme. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P07858

CATB_HUMAN

Homo sapiens

Cathepsin B

PDB Structure

PDB	6AY2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity. Wei, B., Gunzner-Toste, J., Yao, H., Wang, T., Wang, J., Xu, Z., Chen, J., Wai, J., Nonomiya, J., Tsai, S.P., Chuh, J., Kozak, K.R., Liu, Y., Yu, S.F., Lau, J., Li, G., Phillips, G.D., Leipold, D., Kamath, A., Su, D., Xu, K., Eigenbrot, C., Steinbacher, S., Ohri, R., Raab, H., Staben, L.R., Zhao, G., Flygare, J.A., Pillow, T.H., Verma, V., Masterson, L.A., Howard, P.W., Safina, B. J. Med. Chem.