CATH / Gene3D v4.3

151 million protein domains classified into 5,481 superfamilies

Core classification files for the latest version of CATH-Plus (v4.3) are now available to download. Daily updates of our very latest classifications are also available.

3D Structure

Find out what 3D structure your protein adopts

Protein Evolution

Learn about a particular protein family and how it evolved

Protein Function

Investigate the function of your protein

Conserved Sites

Look at protein sites that are highly conserved and implicated in function

Download Data

Download data files and query CATH via webservices

Learn more

Find out how CATH is created and maintained, how to link to CATH and more


What is CATH-Gene3D?

CATH is a classification of protein structures downloaded from the Protein Data Bank. We group protein domains into superfamilies when there is sufficient evidence they have diverged from a common ancestor.

Gene3D uses the information in CATH to predict the locations of structural domains on millions of protein sequences available in public databases. This allows us to include additional annotations to the CATH-Gene3D database such as functional information and active site residues.

If you have any questions, comments or suggestions please get in touch via Twitter, ask a question in our online forum or visit our support page.

Latest Release Statistics Info

CATH-Plus 4.3.0 CATH (daily snapshot)
PDB Release 01-07-2019
Domains 500238 536769
Superfamilies 5481 6631
Annotated PDBs 131091 164636

Gene3D v21
Protein Sequences82,665,384
CATH Domain Predictions151,013,797


Citing this resource

If you find the information in this resource useful, please consider using the following citations:

CATH: expanding the horizons of structure-based functional annotations for genome sequences
Ian Sillitoe, Natalie Dawson, Tony E Lewis, Sayoni Das, Jonathan G Lees, Paul Ashford, Adeyelu Tolulope, Harry M Scholes, Ilya Senatorov, Andra Bujan, Fatima Ceballos Rodriguez-Conde, Benjamin Dowling, Janet Thornton, Christine A Orengo.
Nucleic Acids Res. 2019 Jan
Gene3D: Extensive prediction of globular domains in proteins.
Lewis TE, Sillitoe I, Dawson N, Lam SD, Clarke T, Orengo CA, Lees JG.
Nucleic Acids Res. 2018 Jan

Funding

The CATH and Gene3D resources have enjoyed generous funding from a number of research councils.

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