CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Dipeptidyl peptidase 1

Enzyme Information

3.4.14.1
Dipeptidyl-peptidase I.
based on mapping to UniProt P53634
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.
-!- Also polymerizes dipeptide amides, arylamides and esters at neutral pH. -!- Cl(-)-dependent lysosomal cysteine-type peptidase. -!- Belongs to peptidase family C1. -!- Formerly EC 3.4.4.9.

UniProtKB Entries (1)

P53634
CATC_HUMAN
Homo sapiens
Dipeptidyl peptidase 1

PDB Structure

PDB 3PDF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Novel Cyanamide-Based Inhibitors of Cathepsin C
Laine, D., Palovich, M., McCleland, P., Petitjean, E., Delhom, I., Xie, H., Deng, J., Lin, G., Davis, R., Jolit, A., Nevins, N., Villa, J., Schneck, J.
To be Published