CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family ubiquitin carboxyl-terminal hydrolase 15 isoform X1

Enzyme Information

3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt Q9Y4E8
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

Q9Y4E8
UBP15_HUMAN
Homo sapiens
Ubiquitin carboxyl-terminal hydrolase 15

PDB Structure

PDB 6ML1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Teyra, J., Singer, A.U., Schmitges, F.W., Jaynes, P., Kit Leng Lui, S., Polyak, M.J., Fodil, N., Krieger, J.R., Tong, J., Schwerdtfeger, C., Brasher, B.B., Ceccarelli, D.F.J., Moffat, J., Sicheri, F., Moran, M.F., Gros, P., Eichhorn, P.J.A., Lenter, M., Boehmelt, G., Sidhu, S.S.
Structure