CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Cathepsin Z

Enzyme Information

3.4.18.1
Cathepsin X.
based on mapping to UniProt Q9UBR2
Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.
-!- Deamidates Z-Arg-NH(2), but shows no action on the arylamide derivatives. -!- Inhibited by thiol-blocking reagents. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

Q9UBR2
CATZ_HUMAN
Homo sapiens
Cathepsin Z

PDB Structure

PDB 1EF7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease.
Guncar, G., Klemencic, I., Turk, B., Turk, V., Karaoglanovic-Carmona, A., Juliano, L., Turk, D.
Structure Fold.Des.