The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ribonuclease H-like superfamily/Ribonuclease H
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1060
3D
6n4oA04 - 71.4
2
852
3D
1hjrD00 - 94.1
3
715
3D
2igiB00 - 97.1
4
586
3D
3iayA03 - 91.8
5
512
3D
4gmjF00 - 84.7
6
459 - - 88.2
17
452
3D
5hrsA00 - 76.4
8
440
3D
3aa5X00 - 84.5
9
407
3D
4kb1B00 - 75.3
25
397
3D
5j2qA05 - 78.5
7
376
3D
1wljA00 - 95.3
10
323 - - 90.6
12
291
3D
2xy8A00 - 94.7
11
288 - - 82.8
13
272 - - 78.7
14
237 - - 90.8
16
224
3D
3pufP01 - 94.0
15
218 - - 63.1
20
198
3D
4fzzB00 - 29.7
18
198
3D
4qclA03 - 86.8
19
194 - - 88.1
21
191 - - 82.1
22
190
3D
3sahB01 - 87.3
26
180
3D
2kzzA01 - 95.9
23
174 - - 46.5
24
171 - - 92.6
27
160 - - 82.0
28
149 - - 90.5
46
144
3D
5ywvB01 - 91.4
29
142
3D
2xriA01 - 47.4
30
141 - - 75.1
33
138
3D
4js5B01 - 90.0
31
134 - - 96.3
32
132 - - 96.7
34
124
3D
1zbuD01 - 90.9
35
A
122
3D
2a1sD01 - 65.1
36
117
3D
4fydB03 - 85.7
263
109
3D
5uoqB00 - 28.9
37
107 - - 74.4
38
107 - - 72.9
39
105 - - 85.4
41
102 - - 92.8
40
102 - - 82.8
42
A
100 - - 47.8
49
100
3D
2qkkW00 - 77.7
52
97
3D
3maqA03 - 77.3
45
96
3D
2p1jB01 - 98.2
43
96 - - 89.2
44
94 - - 7.7
47
93
3D
3vn5A02 - 91.4
48
90
3D
3g10A00 - 91.0
53
90
3D
2e6mA00 - 78.7
50
86 - - 31.1
51
86 - - 77.6
54
79 - - 96.5
55
78 - - 71.6
56
73 - - 73.5
57
69 - - 56.6
58
68 - - 87.6
59
66
3D
4nlcA01 - 88.5
60
64
3D
1yt3A01 - 82.1
61
61 - - 89.4
62
59 - - 72.7
63
55 - - 93.8
65
54 - - 76.4
64
54 - - 71.8
66
53 - - 74.9
67
51 - - 94.6
68
49 - - 63.2
72
47
3D
1nozB02 - 27.7
69
46 - - 70.6
70
45 - - 73.9
73
43 - - 17.2
71
43 - - 47.7
74
42 - - 87.7
75
41 - - 4.7
76
40 - - 95.0
77
39 - - 87.9
79
38 - - 73.6
78
38 - - 82.2
80
37 - - 80.6
81
36 - - 83.5
82
36 - - 78.8
83
35 - - 14.2
85
31 - - 21.9
84
31 - - 0.0
89
30
3D
3h08B00 - 88.2
86
29 - - 32.5
88
28 - - 73.6
87
28 - - 83.3
92
27 - - 9.6
91
27 - - 85.8
449
27
3D
2pzsD01 - 3.9
90
27 - - 86.7
107
A
26
3D
4b8cF00 - 77.5
161
26
3D
5v5fC00 - 88.0
93
26 - - 23.8
95
24 - - 62.1
94
24 - - 29.6
102
23
3D
5dmrA00 - 33.2
184
23
3D
4fw2B01 - 16.6
96
22 - - 63.6
97
22 - - 89.0
98
21 - - 49.3
99
21 - - 14.3
101
21 - - 77.8
139
21
3D
2dfhA01 - 92.7
100
Wrn
21 - - 84.2
157
20
3D
5dk5B01 - 90.0
104
19 - - 84.1
106
19 - - 7.2
103
19 - - 69.4
105
19 - - 3.5
110
18 - - 4.8
111
18 - - 22.4
142
18
3D
4hhtA00 - 77.7
108
18 - - 1.2
163
18
3D
5c0yB01 - 14.0
112
18 - - 9.4
109
18 - - 69.6
113
17 - - 81.7
119
17 - - 34.1
115
17 - - 89.6
120
A
17 - - 83.2
114
17 - - 75.1
117
17 - - 0.7
118
A
17 - - 3.8
116
3'-5' exonuclease
17 - - 4.5
123
A
16 - - 8.9
134
16
3D
1wnsA02 - 25.6
121
16 - - 17.7
124
16 - - 4.8
122
16 - - 5.8
129
15 - - 7.9
125
15 - - 0.0
127
15 - - 11.7
130
15 - - 61.6
126
15 - - 13.7
128
A
15 - - 48.2
131
15 - - 78.1
160
14
3D
1kcfB00 - 87.4
132
14 - - 17.0
137
14 - - 0.0
138
14 - - 78.0
136
A
14 - - 18.3
140
14 - - 95.3
133
14 - - 49.7
135
14 - - 17.0
146
13 - - 62.8
183
13
3D
4fcyB03 - 26.8
148
13 - - 3.6
147
13 - - 14.0
150
13 - - 80.3
144
13 - - 13.8
151
13 - - 79.5
141
13 - - 21.3
145
13 - - 78.1
149
13 - - 83.8
143
13 - - 6.6
164
13
3D
2ajqF01 - 13.9
153
12 - - 0.0
159
12 - - 83.6
155
12 - - 2.8
152
12 - - 1.9
154
12 - - 92.1
158
12 - - 47.8
156
12 - - 84.6
165
11 - - 42.1
166
11 - - 82.7
162
11 - - 28.4
167
11 - - 82.8
176
10 - - 17.7
169
10 - - 76.9
178
10 - - 8.2
174
10 - - 31.3
177
10 - - 42.2
172
10 - - 41.0
171
10 - - 0.0
168
10 - - 32.2
179
10 - - 65.3
175
10 - - 86.8
170
10 - - 1.4
173
10 - - 62.2
180
9 - - 38.9
185
9 - - 9.6
181
9 - - 84.5
182
9 - - 2.6
187
9 - - 66.2
186
9 - - 85.4
194
8 - - 36.9
192
8 - - 7.4
196
A
8 - - 41.1
189
8 - - 43.4
208
8
3D
1s5jA02 - 74.1
193
8 - - 37.6
191
8 - - 11.8
188
8 - - 0.7
195
8 - - 69.1
190
8 - - 18.1
213
7 - - 0.0
202
7 - - 69.1
197
7 - - 32.2
207
7 - - 3.3
204
7 - - 21.1
211
7 - - 1.1
220
7 - - 80.8
221
7 - - 95.3
219
7 - - 67.0
198
7 - - 32.6
210
7 - - 5.5
206
7 - - 8.3
215
7 - - 91.7
214
7 - - 15.5
217
7 - - 62.6
212
7 - - 15.4
203
7 - - 13.5
205
7 - - 1.3
200
7 - - 62.5
216
7 - - 3.3
209
7 - - 2.9
218
7 - - 41.3
199
7 - - 15.5
201
7 - - 38.8
237
6 - - 0.5
234
6 - - 8.9
232
6 - - 72.2
223
6 - - 69.3
229
6 - - 13.9
225
6 - - 5.9
236
6 - - 5.4
238
6 - - 55.7
240
6 - - 92.3
233
6 - - 5.3
222
6 - - 47.2
224
6 - - 12.2
227
6 - - 4.5
228
6 - - 12.6
231
6 - - 4.0
226
6 - - 0.0
230
6 - - 0.6
235
6 - - 4.3
239
6 - - 23.5
253
5 - - 5.5
248
5 - - 3.5
261
5 - - 6.5
260
5 - - 6.3
276
5 - - 76.0
265
5 - - 8.5
246
5 - - 66.7
269
5 - - 78.7
242
5 - - 72.4
251
5 - - 2.5
272
5 - - 53.5
259
DNA directed
5 - - 33.4
247
5 - - 80.4
274
5 - - 77.5
244
5 - - 68.4
250
5 - - 9.2
255
5 - - 11.9
245
5 - - 12.3
254
5 - - 0.0
270
5 - - 0.0
257
5 - - 9.2
275
5 - - 66.8
249
5 - - 2.1
266
5 - - 79.3
271
5 - - 85.3
252
5 - - 1.8
268
5 - - 7.6
241
5 - - 50.5
267
5 - - 12.0
256
5 - - 4.7
264
5 - - 0.0
262
5 - - 2.5
258
5 - - 13.0
273
5 - - 76.5
243
5 - - 29.5
278
4 - - 59.9
283
4 - - 7.7
292
4 - - 5.7
308
4 - - 70.0
294
4 - - 36.3
306
4 - - 65.8
310
4 - - 63.1
297
4 - - 68.7
281
4 - - 21.4
298
4 - - 74.8
302
A
4 - - 19.4
289
4 - - 9.0
307
4 - - 46.2
296
4 - - 3.0
304
4 - - 87.8
277
4 - - 25.7
285
4 - - 9.5
280
4 - - 28.1
279
4 - - 80.8
305
4 - - 12.5
284
4 - - 0.0
300
A
4 - - 44.5
287
4 - - 12.9
309
4 - - 70.0
293
4 - - 19.6
335
4
3D
2lsnA00 - 14.4
301
4 - - 5.3
282
4 - - 72.7
286
4 - - 5.8
299
Plant
4 - - 12.8
290
4 - - 0.7
295
4 - - 1.9
288
4 - - 2.5
291
4 - - 7.5
303
4 - - 10.3
329
3 - - 9.4
342
3 - - 53.5
311
3 - - 2.1
351
3 - - 37.5
325
3 - - 0.0
320
3 - - 13.5
336
3 - - 9.8
321
3 - - 35.3
319
3 - - 4.0
347
3 - - 8.3
344
3 - - 0.0
338
DNA directed
3 - - 5.3
350
3 - - 51.6
315
3 - - 33.4
353
3 - - 38.4
313
3 - - 25.6
337
3 - - 9.0
334
3 - - 10.4
348
3 - - 0.0
332
3 - - 5.0
323
3 - - 56.9
346
3 - - 9.4
328
3 - - 12.2
316
3 - - 58.3
331
3 - - 16.8
326
3 - - 0.4
330
3 - - 2.1
318
DNA directed
3 - - 2.4
339
3 - - 14.0
343
A
3 - - 11.8
345
3 - - 11.5
354
3 - - 81.4
314
3 - - 31.4
340
3 - - 1.3
333
3 - - 0.0
317
3 - - 1.2
349
3 - - 6.9
322
3 - - 17.8
324
3 - - 0.0
352
3 - - 65.4
312
3 - - 9.6
341
3 - - 4.7
327
3 - - 0.5
456
2 - - 0.4
400
2 - - 0.0
381
2 - - 32.8
416
2 - - 0.0
428
2 - - 10.1
398
2 - - 1.0
405
2 - - 0.0
467
2 - - 0.0
486
2 - - 39.9
409
2 - - 0.0
431
2 - - 12.1
363
2 - - 0.7
372
2 - - 20.6
464
2 - - 0.0
490
2 - - 11.5
435
2 - - 36.9
491
2 - - 45.1
359
2 - - 1.2
488
2 - - 39.1
418
2 - - 0.0
430
2 - - 24.1
389
2 - - 11.2
473
2 - - 0.0
458
2 - - 0.0
396
2 - - 0.0
374
2 - - 22.1
462
2 - - 0.5
426
2 - - 0.0
385
2 - - 38.8
377
2 - - 25.3
443
2 - - 0.0
439
2 - - 12.2
401
2 - - 0.0
380
2 - - 33.1
355
2 - - 0.0
440
2 - - 9.0
378
2 - - 30.9
454
2 - - 0.0
414
2 - - 5.4
484
2 - - 35.4
445
2 - - 0.6
479
2 - - 50.8
383
2 - - 30.7
392
2 - - 7.5
422
2 - - 7.5
466
2 - - 0.0
475
2 - - 0.0
487
2 - - 24.7
457
2 - - 0.0
417
2 - - 2.7
361
2 - - 0.0
433
2 - - 29.8
470
2 - - 0.0
360
2 - - 39.1
471
2 - - 1.9
376
2 - - 22.3
394
2 - - 0.0
424
2 - - 0.0
493
2 - - 43.6
365
2 - - 10.0
482
2 - - 31.2
397
2 - - 0.0
403
2 - - 4.3
427
2 - - 20.0
369
2 - - 17.8
468
2 - - 36.7
441
2 - - 0.0
452
2 - - 0.0
412
2 - - 0.7
411
2 - - 0.0
386
2 - - 43.2
451
2 - - 0.0
399
2 - - 1.6
442
2 - - 0.0
429
2 - - 16.6
367
2 - - 14.5
356
2 - - 0.0
481
2 - - 21.1
408
2 - - 3.8
436
2 - - 45.8
420
2 - - 0.0
390
2 - - 0.0
472
2 - - 0.0
364
2 - - 4.4
395
2 - - 2.1
425
2 - - 0.0
463
2 - - 6.3
474
2 - - 0.0
447
2 - - 2.6
362
2 - - 5.0
373
2 - - 24.6
489
2 - - 43.9
358
2 - - 0.0
459
2 - - 0.0
388
2 - - 0.0
419
2 - - 5.2
421
2 - - 0.0
391
2 - - 1.1
455
2 - - 2.8
415
2 - - 11.3
480
2 - - 0.0
438
2 - - 44.2
410
2 - - 0.7
406
2 - - 0.0
450
2 - - 0.0
477
2 - - 0.0
485
2 - - 37.4
444
2 - - 0.0
483
2 - - 34.0
379
2 - - 28.5
402
2 - - 0.0
384
2 - - 40.5
437
2 - - 38.4
453
2 - - 4.8
478
2 - - 9.3
413
2 - - 0.0
448
2 - - 8.9
461
2 - - 6.9
370
2 - - 18.0
357
2 - - 0.0
434
2 - - 39.0
387
2 - - 45.8
375
2 - - 10.1
492
2 - - 41.8
366
2 - - 47.2
393
2 - - 0.0
407
2 - - 0.0
465
2 - - 5.1
423
2 - - 0.0
494
2 - - 34.8
476
2 - - 0.0
460
2 - - 0.0
371
2 - - 7.6
432
2 - - 33.0
368
2 - - 10.0
469
2 - - 5.1
446
2 - - 0.6
404
2 - - 0.0
382
2 - - 37.8
702
1 - - 0.0
687
1 - - 0.0
675
1 - - 0.0
649
1 - - 0.0
666
1 - - 0.0
622
1 - - 0.0
670
1 - - 0.0
569
1 - - 0.0
546
1 - - 0.0
633
1 - - 0.0
713
1 - - 0.0
499
1 - - 0.0
753
1 - - 0.0
597
1 - - 0.0
737
1 - - 0.0
617
1 - - 0.0
657
1 - - 0.0
504
1 - - 0.0
495
1 - - 0.0
734
1 - - 0.0
523
1 - - 0.0
614
1 - - 0.0
565
1 - - 0.0
654
1 - - 0.0
507
1 - - 0.0
640
1 - - 0.0
748
1 - - 0.0
576
1 - - 0.0
594
1 - - 0.0
679
1 - - 0.0
560
1 - - 0.0
645
1 - - 0.0
532
1 - - 0.0
684
1 - - 0.0
627
1 - - 0.0
603
1 - - 0.0
561
1 - - 0.0
548
1 - - 0.0
534
1 - - 0.0
723
1 - - 0.0
707
1 - - 0.0
682
1 - - 0.0
732
1 - - 0.0
612
1 - - 0.0
652
1 - - 0.0
641
1 - - 0.0
592
1 - - 0.0
668
1 - - 0.0
671
1 - - 0.0
583
1 - - 0.0
502
1 - - 0.0
537
1 - - 0.0
693
1 - - 0.0
704
1 - - 0.0
513
1 - - 0.0
624
1 - - 0.0
746
1 - - 0.0
578
1 - - 0.0
553
1 - - 0.0
742
1 - - 0.0
664
1 - - 0.0
729
1 - - 0.0
515
1 - - 0.0
555
1 - - 0.0
751
1 - - 0.0
580
1 - - 0.0
631
1 - - 0.0
609
1 - - 0.0
711
1 - - 0.0
695
1 - - 0.0
550
1 - - 0.0
506
1 - - 0.0
510
1 - - 0.0
538
1 - - 0.0
690
1 - - 0.0
544
1 - - 0.0
585
1 - - 0.0
577
1 - - 0.0
547
1 - - 0.0
596
1 - - 0.0
720
1 - - 0.0
574
1 - - 0.0
628
1 - - 0.0
616
1 - - 0.0
708
1 - - 0.0
600
1 - - 0.0
736
1 - - 0.0
656
1 - - 0.0
589
1 - - 0.0
725
1 - - 0.0
519
1 - - 0.0
686
1 - - 0.0
559
1 - - 0.0
667
1 - - 0.0
699
1 - - 0.0
521
1 - - 0.0
605
1 - - 0.0
536
1 - - 0.0
643
1 - - 0.0
508
1 - - 0.0
747
1 - - 0.0
520
1 - - 0.0
721
1 - - 0.0
572
1 - - 0.0
563
1 - - 0.0
601
1 - - 0.0
639
1 - - 0.0
525
1 - - 0.0
719
1 - - 0.0
688
1 - - 0.0
551
1 - - 0.0
511
1 - - 0.0
691
1 - - 0.0
529
1 - - 0.0
715
1 - - 0.0
635
1 - - 0.0
542
1 - - 0.0
755
1 - - 0.0
744
1 - - 0.0
626
1 - - 0.0
598
1 - - 0.0
662
1 - - 0.0
658
1 - - 0.0
750
1 - - 0.0
581
1 - - 0.0
673
1 - - 0.0
738
1 - - 0.0
630
1 - - 0.0
710
1 - - 0.0
706
1 - - 0.0
618
1 - - 0.0
714
1 - - 0.0
634
1 - - 0.0
582
1 - - 0.0
754
1 - - 0.0
527
1 - - 0.0
661
1 - - 0.0
503
1 - - 0.0
648
1 - - 0.0
740
1 - - 0.0
541
1 - - 0.0
498
1 - - 0.0
692
1 - - 0.0
568
1 - - 0.0
745
1 - - 0.0
512
1 - - 0.0
552
1 - - 0.0
602
1 - - 0.0
571
1 - - 0.0
722
1 - - 0.0
749
1 - - 0.0
683
1 - - 0.0
613
1 - - 0.0
733
1 - - 0.0
524
1 - - 0.0
678
1 - - 0.0
653
1 - - 0.0
717
1 - - 0.0
637
1 - - 0.0
593
1 - - 0.0
757
1 - - 0.0
566
1 - - 0.0
549
1 - - 0.0
496
1 - - 0.0
522
1 - - 0.0
587
1 - - 0.0
575
1 - - 0.0
517
1 - - 0.0
557
1 - - 0.0
604
1 - - 0.0
570
1 - - 0.0
646
1 - - 0.0
669
1 - - 0.0
533
1 - - 0.0
724
1 - - 0.0
697
1 - - 0.0
727
1 - - 0.0
540
1 - - 0.0
676
1 - - 0.0
703
1 - - 0.0
694
1 - - 0.0
623
1 - - 0.0
514
1 - - 0.0
665
1 - - 0.0
554
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607
1 - - 0.0
712
1 - - 0.0
545
1 - - 0.0
632
1 - - 0.0
584
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752
1 - - 0.0
579
1 - - 0.0
660
1 - - 0.0
741
1 - - 0.0
728
1 - - 0.0
620
1 - - 0.0
636
1 - - 0.0
543
1 - - 0.0
700
1 - - 0.0
608
1 - - 0.0
716
1 - - 0.0
756
1 - - 0.0
501
1 - - 0.0
663
1 - - 0.0
539
1 - - 0.0
625
1 - - 0.0
705
1 - - 0.0
672
1 - - 0.0
591
1 - - 0.0
629
1 - - 0.0
535
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642
1 - - 0.0
588
1 - - 0.0
651
1 - - 0.0
611
1 - - 0.0
709
1 - - 0.0
731
1 - - 0.0
558
1 - - 0.0
681
1 - - 0.0
573
1 - - 0.0
530
1 - - 0.0
518
1 - - 0.0
526
1 - - 0.0
698
1 - - 0.0
562
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680
1 - - 0.0
531
1 - - 0.0
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1 - - 0.0
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1 - - 0.0
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564
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726
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644
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1 - - 0.0
758
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718
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606
1 - - 0.0
610
1 - - 0.0
730
1 - - 0.0
638
1 - - 0.0
516
1 - - 0.0
500
1 - - 0.0
743
1 - - 0.0
556
1 - - 0.0
689
1 - - 0.0
647
1 - - 0.0
696
1 - - 0.0
674
1 - - 0.0
528
1 - - 0.0
497
1 - - 0.0
567
1 - - 0.0
599
1 - - 0.0
621
1 - - 0.0
505
1 - - 0.0
619
1 - - 0.0
739
1 - - 0.0
701
1 - - 0.0
586
1 - - 0.0
659
1 - - 0.0
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