The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: egl nine homolog 1 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9GZT9 (/IPI) Q9GZT9 (/IPI)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
2 Q9GZT9 (/IDA) Q9GZT9 (/IDA)
2-oxoglutarate-dependent dioxygenase activity GO:0016706
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
2 Q9GZT9 (/IDA) Q9GZT9 (/IDA)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 Q9GZT9 (/ISS) Q9GZT9 (/ISS)
Peptidyl-proline dioxygenase activity GO:0031543
Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2.
2 Q9GZT9 (/TAS) Q9GZT9 (/TAS)
Peptidyl-proline 4-dioxygenase activity GO:0031545
Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2.
2 Q9GZT9 (/EXP) Q9GZT9 (/EXP)
Peptidyl-proline 4-dioxygenase activity GO:0031545
Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2.
2 Q9GZT9 (/IDA) Q9GZT9 (/IDA)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
1 Q91YE3 (/ISO)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
1 Q91YE3 (/ISS)
2-oxoglutarate-dependent dioxygenase activity GO:0016706
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
1 Q91YE3 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q91YE3 (/ISO)
Peptidyl-proline dioxygenase activity GO:0031543
Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2.
1 Q91YE3 (/ISO)
Peptidyl-proline 4-dioxygenase activity GO:0031545
Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2.
1 Q91YE3 (/ISO)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
2 Q9GZT9 (/IDA) Q9GZT9 (/IDA)
Peptidyl-proline hydroxylation to 4-hydroxy-L-proline GO:0018401
The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase.
2 Q9GZT9 (/IDA) Q9GZT9 (/IDA)
Oxygen homeostasis GO:0032364
A homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell.
2 Q9GZT9 (/IDA) Q9GZT9 (/IDA)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
2 Q9GZT9 (/IDA) Q9GZT9 (/IDA)
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
2 Q9GZT9 (/ISS) Q9GZT9 (/ISS)
Negative regulation of cyclic-nucleotide phosphodiesterase activity GO:0051344
Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
2 Q9GZT9 (/ISS) Q9GZT9 (/ISS)
Regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.
2 Q9GZT9 (/TAS) Q9GZT9 (/TAS)
Response to nitric oxide GO:0071731
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.
2 Q9GZT9 (/IDA) Q9GZT9 (/IDA)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q91YE3 (/ISO)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
1 Q91YE3 (/IMP)
Peptidyl-proline hydroxylation to 4-hydroxy-L-proline GO:0018401
The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase.
1 Q91YE3 (/ISO)
Oxygen homeostasis GO:0032364
A homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell.
1 Q91YE3 (/ISO)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q91YE3 (/ISO)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q91YE3 (/ISO)
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
1 Q91YE3 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q91YE3 (/IMP)
Negative regulation of cyclic-nucleotide phosphodiesterase activity GO:0051344
Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
1 Q91YE3 (/ISO)
Cardiac muscle tissue morphogenesis GO:0055008
The process in which the anatomical structures of cardiac muscle tissue are generated and organized.
1 Q91YE3 (/IMP)
Heart trabecula formation GO:0060347
The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod.
1 Q91YE3 (/IMP)
Ventricular septum morphogenesis GO:0060412
The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another.
1 Q91YE3 (/IMP)
Labyrinthine layer development GO:0060711
The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state.
1 Q91YE3 (/IMP)
Response to nitric oxide GO:0071731
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.
1 Q91YE3 (/ISO)
Response to nitric oxide GO:0071731
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus.
1 Q91YE3 (/ISS)
Regulation of postsynapse organization GO:0099175
Any process that modulates the physical form of a postsynapse.
1 Q91YE3 (/IDA)
Regulation of postsynapse organization GO:0099175
Any process that modulates the physical form of a postsynapse.
1 Q91YE3 (/IMP)
Regulation of protein catabolic process at postsynapse, modulating synaptic transmission GO:0099576
Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.
1 Q91YE3 (/IDA)
Regulation of protein catabolic process at postsynapse, modulating synaptic transmission GO:0099576
Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.
1 Q91YE3 (/IMP)
Regulation of neuron death GO:1901214
Any process that modulates the frequency, rate or extent of neuron death.
1 Q91YE3 (/IMP)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
1 Q91YE3 (/ISO)
Negative regulation of CAMKK-AMPK signaling cascade GO:1905290
Any process that stops, prevents or reduces the frequency, rate or extent of CAMKK-AMPK signaling cascade.
1 Q91YE3 (/ISO)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q9GZT9 (/IDA) Q9GZT9 (/IDA) R4SCQ0 (/IDA) R4SCQ0 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9GZT9 (/IDA) Q9GZT9 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9GZT9 (/TAS) Q9GZT9 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q91YE3 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q91YE3 (/ISO)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 Q91YE3 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q91YE3 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q91YE3 (/IMP)
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