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CATH Superfamily 6.10.140.2220

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: egl nine homolog 1 isoform X1

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Hypoxia-inducible factor-proline dioxygenase. [EC: 1.14.11.29]
Hypoxia-inducible factor-L-proline + 2-oxoglutarate + O(2) = hypoxia- inducible factor-trans-4-hydroxy-L-proline + succinate + CO(2).
  • Contains iron, and requires ascorbate.
  • Specifically hydroxylates a proline residue in HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which targets HIF for proteasomal destruction.
  • The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.
 5 Q91YE3 Q9GZT9 Q9GZT9 R4SCQ0 R4SCQ0
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