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CATH Superfamily 3.40.47.10

Thiolase/Chalcone synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
3-ketoacyl-CoA thiolase
1064
3D
 5lp7H01 - 89.4
2
Acetyl-CoA acetyltransferase
930
3D
 5f38D02 - 95.9
3
3-ketoacyl-CoA thiolase
756
3D
 1pxtB02 - 94.2
5
3-oxoacyl-[acyl-carrier-protein] synthase I
543
3D
 2vbaD02 - 72.7
6
3-oxoacyl-[acyl-carrier-protein] synthase I
538
3D
 2vbaD01 - 76.2
4
3-oxoacyl-[acyl-carrier-protein] synthase 3
538 - - 96.2
14
Chalcone synthase 1
426
3D
 3tsyA03 - 99.3
8
3-hydroxy-3-methylglutaryl coenzyme A synthase
419
3D
 2fa3A00 - 91.8
7
acetyl-CoA acetyltransferase, mitochondrial
417 - - 86.7
9
3-oxoacyl-[acyl-carrier-protein] synthase 2
370 - - 92.3
10
Acetyl-CoA acetyltransferase
Thiolase
349 - - 92.5
25
Chalcone synthase 2
317
3D
 3tsyA02 - 96.5
12
3-ketoacyl-CoA thiolase, peroxisomal
294
3D
 1pxtB01 - 89.7
11
3-ketoacyl-CoA thiolase
292 - - 92.0
18
3-oxoacyl-[acyl-carrier-protein] synthase 2
273
3D
 5ld8B01 - 96.9
13
Acetyl-CoA acetyltransferase
262 - - 92.8
15
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
251
3D
 2iwzB02 - 90.2
19
Polyketide synthase type I
244
3D
 5erfB01 - 95.3
16
Non-specific lipid-transfer protein
235 - - 85.9
17
Acetyl-CoA acetyltransferase
225
3D
 4b3jD02 - 74.6
21
Fatty acid synthase subunit alpha
198
3D
 2uv8C05 - 84.7
20
Putative trifunctional enzyme subunit beta mitochondrial
197 - - 73.1
22
Acetyl-CoA acetyltransferase
179 - - 41.3
23
Acetyl-CoA acetyltransferase
177 - - 74.3
24
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
174
3D
 2ix4B01 - 90.7
29
3-oxoacyl-[acyl-carrier-protein] synthase 1
161
3D
 5ld8B02 - 93.9
26
3-oxoacyl-[acyl-carrier-protein] synthase 2
156 - - 52.1
27
3-oxoacyl-[acyl-carrier-protein] synthase 2
139 - - 80.2
30
Acetyl-CoA acetyltransferase
122
3D
 4b3jD01 - 72.9
33
Fatty acid synthase
121
3D
 5my0D01 - 72.3
32
Peroxisomal 3-ketoacyl-CoA thiolase
118
3D
 2wu9B00 - 77.8
28
3-ketoacyl-CoA synthase
118 - - 83.3
31
Sterigmatocystin biosynthesis polyketide synthase
112 - - 76.3
37
3-oxoacyl-ACP synthase III
109
3D
 6b2tB02 - 31.8
34
Acetyl-CoA acetyltransferase, cytosolic
106
3D
 1wl5A01 - 74.5
35
3-ketoacyl-CoA thiolase A, peroxisomal
84
3D
 2iikB00 - 65.7
36
3-oxoacyl-[acyl-carrier-protein] synthase II chloroplastic
80 - - 56.9
38
3-oxoacyl-[acyl-carrier-protein] synthase 2
69 - - 25.4
39
3-oxoacyl-[acyl-carrier-protein] synthase 2
68 - - 57.0
40
Type III polyketide synthase
64
3D
 1u0mB01 - 62.1
55
3-oxoacyl-ACP synthase III
62
3D
 6b2tB01 - 14.2
41
Lipid-transfer protein
62 - - 36.7
43
3-hydroxy-3-methylglutaryl CoA synthase
60
3D
 4yxqD01 - 76.8
53
Alpha-pyrone synthesis polyketide synthase
55
3D
 4jd3D01 - 60.4
45
Hydroxymethylglutaryl-CoA synthase
52
3D
 1xpkC02 - 66.0
42
Polyketide synthase Pks13
44
3D
 4wkyB01 - 90.6
50
3-oxoacyl-[acyl-carrier-protein] synthase 2
43
3D
 2rjtD02 - 18.8
71
3-oxoacyl-[acyl-carrier-protein] synthase 3
39
3D
 2qx1B02 - 23.9
76
3-oxoacyl-[acyl-carrier-protein] synthase 3
39
3D
 2qx1B01 - 51.8
44
Probable acetyl-CoA acyltransferase
39 - - 34.6
46
UPF0219 protein M1627_1703
35 - - 79.1
48
3-oxoacyl-Acyl-carrier-protein synthase III
34 - - 15.2
47
Acetyl-CoA acetyltransferase FadA6
34 - - 30.6
49
3-oxoacyl-Acyl-carrier-protein synthase III
33 - - 47.6
56
3-oxoacyl-[acyl-carrier-protein] synthase 3
33
3D
 4nhdD01 - 90.4
51
3-oxoacyl-Acyl-carrier-protein synthase III
32 - - 53.6
52
Beta-ketoacyl-acyl-carrier-protein synthase III
32 - - 11.3
54
Acetyl-CoA C-acetyltransferase VraB
31 - - 62.0
58
Acetyl-CoA C-acetyltransferase
27 - - 6.6
57
3-ketoacyl-CoA synthase
27 - - 60.6
59
Beta-ketoacyl-acyl-carrier-protein synthase II
23 - - 77.2
62
Acetyl-CoA acetyltransferase FadA2
22 - - 27.5
61
Thiolase, C-terminal domain protein
22 - - 6.1
60
Acetyl-CoA acyltransferase 1
22 - - 44.3
85
2-heptyl-4
1H
22
3D
 6et3C02 - 0.0
68
3-oxoacyl-[acyl-carrier-protein] synthase 3
22
3D
 4nhdD02 - 35.5
70
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
22
3D
 2iwzB01 - 31.9
63
Trifunctional enzyme subunit beta, mitochondrial
21 - - 24.3
64
Acetyl-CoA acetyltransferase FadA5
20 - - 21.7
122
Nonspecific lipid-transfer protein, putative
20
3D
 5ab7F00 - 1.1
65
Acetyl-CoA acyltransferase 1
19 - - 41.7
66
Fatty acid synthase subunit alpha, fungi type
19 - - 16.7
67
Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
18 - - 29.3
69
Acetyl-CoA C-acetyltransferase, putative
17 - - 54.7
88
Putative chalcone synthase
17
3D
 3wy0B01 - 66.8
72
Thiolase
15 - - 18.7
73
Acetyl-CoA acetyltransferase
15 - - 82.4
74
Fatty acid synthase
15 - - 27.1
75
Acetyl-CoA acetyltransferase
15 - - 54.6
77
3-oxoacyl-[acyl-carrier-protein] synthase 2
14 - - 14.7
89
Putative polyketide beta-ketoacyl synthase 2
14
3D
 1tqyH02 - 94.1
105
Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG
14
3D
 4yxvB02 - 0.0
78
Acetyl-CoA acetyltransferase FadA5
13 - - 12.8
79
Acetyl-CoA acetyltransferase, putative
13 - - 8.4
80
3-oxoacyl-[acyl-carrier protein] synthase II
13 - - 9.6
104
Bisdemethoxycurcumin synthase
12
3D
 3oitB02 - 8.2
125
3-ketoacyl-CoA thiolase, mitochondrial
12
3D
 4c2kD02 - 37.4
81
3-oxoacyl-[acyl-carrier-protein] synthase 2
12 - - 79.6
84
Beta-keto-ACP synthase
11 - - 0.0
87
3-oxoacyl-[acyl-carrier-protein] synthase 3
11 - - 0.0
82
GD13606
11 - - 32.1
83
Probable acyl-CoA thiolase
11 - - 8.9
86
3-hydroxy-3-methylglutaryl-CoA synthase, putative
11 - - 26.9
92
Alpha-pyrone synthesis polyketide synthase-like Pks18
11
3D
 1tedD01 - 0.0
119
Anthraniloyl-CoA anthraniloyltransferase
10
3D
 3h78B02 - 71.5
90
Lipid transfer protein or keto acyl-CoA thiolase Ltp2
10 - - 13.4
91
Probable polyketide synthase 32
10 - - 71.8
106
Actinorhodin polyketide putative beta-ketoacyl synthase 2
10
3D
 1tqyH01 - 15.6
93
3-hydroxy-3-methylglutaryl coenzyme A synthase
9 - - 19.3
117
4-hydroxycoumarin synthase 1
9 - - 9.6
96
Acetyl-CoA C-acetyltransferase
8 - - 17.7
98
Uncharacterized protein B0303.3
8 - - 45.7
107
3-oxoacyl-[acyl-carrier-protein] synthase 3
8
3D
 4x0oD00 - 0.0
94
3-oxoacyl-[acyl-carrier-protein] synthase 2
8 - - 64.1
97
Acetyl-CoA acetyltransferase 2
8 - - 63.7
95
Uncharacterized protein
8 - - 17.9
101
Beta-ketoacyl synthase
7 - - 0.0
100
Beta-ketoacyl synthase, N-terminal domain protein
7 - - 9.9
99
3-oxoacyl-[acyl-carrier-protein] synthase 3
7 - - 5.2
102
Keto acyl-CoA thiolase
7 - - 0.0
177
3-ketoacyl-CoA thiolase, putative
6
3D
 4bi9D00 - 0.0
109
2-heptyl-4
1H
6 - - 0.0
110
Fatty acid synthase subunit alpha
6 - - 2.4
108
Beta-ketoacyl-ACP synthase III
6 - - 2.7
103
3,5-dihydroxyphenylacetyl-CoA synthase
6 - - 29.2
111
Uncharacterized protein
6 - - 28.8
113
Putative 3-oxoacyl-
Acyl-carrier-protein
5 - - 16.8
116
GumO
5 - - 2.9
112
3-oxoacyl-
Acyl-carrier-protein
5 - - 37.2
114
Uncharacterized protein
5 - - 12.3
115
Uncharacterized protein
5 - - 12.1
127
Acetyl-CoA acetyltransferase, putative
4 - - 67.4
118
3-hydroxy-3-methylglutaryl coenzyme A synthase
4 - - 28.7
129
3-hydroxy-3-methylglutaryl coenzyme A synthase
4 - - 49.5
124
Possible lipid transfer protein or keto acyl-CoA thiolase Ltp4
4 - - 3.0
120
Uncharacterized protein
4 - - 1.2
126
Protein CBG20965
4 - - 66.1
128
Fatty acid synthase subunit beta
4 - - 39.9
130
3-oxoacyl-[acyl-carrier-protein] synthase 2
4 - - 27.9
131
Uncharacterized protein
4 - - 34.3
121
Beta-ketoacyl-ACP synthase II
4 - - 3.6
123
Putative hydroxymethylglutaryl-CoA synthase
4 - - 10.8
139
Polyketide beta-ketoacyl:acyl carrier proteinsynthase
3 - - 0.0
135
Beta-ketoacyl synthase
3 - - 0.0
145
Polyketide synthase
3 - - 13.2
136
3 - - 14.1
144
3 - - 0.0
138
3-oxoacyl-[acyl-carrier-protein] synthase 2
3 - - 3.2
137
Protein CBG03789
3 - - 11.9
142
Hydroxymethylglutaryl-CoA synthase
3 - - 7.2
140
Acetyl-CoA acetyltransferase
3 - - 0.0
143
Fatty acid synthase subunit beta
3 - - 37.1
132
3 - - 78.0
148
3 - - 19.9
147
Polyketide synthase type I
3 - - 0.7
133
3-hydroxy-3-methylglutaryl coenzyme A synthase
3 - - 0.4
141
Putative 3-oxoacyl-
Acyl-carrier-protein
3 - - 1.9
134
Acetyl-CoA C-acyltransferase
3 - - 2.5
146
Orsellinic acid synthase
3 - - 13.5
194
Polyketide synthase RzxE
2 - - 6.9
153
2 - - 6.1
168
2 - - 9.0
178
3-oxoacyl-[acyl-carrier-protein] synthase
2 - - 0.0
160
Beta-ketoacyl synthase PigJ
2 - - 0.0
193
2 - - 34.9
180
Acetyl-CoA acetyltransferase
2 - - 2.2
152
3-ketoacyl-CoA-synthase
2 - - 3.7
189
2 - - 8.3
171
2 - - 23.8
200
2 - - 16.3
161
Putative polyketide beta-ketoacyl synthase 2
2 - - 5.7
151
Beta-ketoacyl synthase PigJ
2 - - 1.0
197
2 - - 10.2
191
Hydroxymethylglutaryl-CoA synthase
2 - - 2.3
187
2 - - 9.7
176
Trifunctional enzyme subunit beta, mitochondrial
2 - - 1.6
170
3-hydroxy-3-methylglutaryl coenzyme A synthase
2 - - 9.1
182
Thiolase
2 - - 0.0
167
3-oxoacyl-
Acyl carrier protein
2 - - 0.0
192
3-oxoacyl-[acyl-carrier-protein] synthase II
2 - - 3.7
150
2 - - 27.5
155
2 - - 0.0
163
2 - - 0.0
175
2 - - 44.9
199
2 - - 35.5
198
2 - - 25.4
184
Acetoacetyl CoA synthase NphT7
2 - - 6.6
181
Beta ketoacyl-acyl carrier protein synthase
2 - - 0.0
154
2 - - 9.3
159
2 - - 0.0
195
Amino acid adenylation domain protein
2 - - 0.3
162
2 - - 0.0
174
2 - - 40.5
188
2 - - 0.0
158
2 - - 0.0
183
3-oxoacyl-
Acyl-carrier-protein
2 - - 0.0
169
3-oxoacyl-[acyl-carrier-protein] synthase
2 - - 21.3
190
3-hydroxy-3-methylglutaryl coenzyme A synthase
2 - - 1.0
157
2 - - 4.0
165
Fatty acid synthase, putative
JCVI
2 - - 0.0
186
3-oxoacyl-[acyl-carrier-protein] synthase 3
2 - - 0.0
172
2 - - 21.3
179
Predicted protein
2 - - 5.3
149
3-hydroxy-3-methylglutaryl coenzyme A synthase
2 - - 14.5
173
2 - - 34.2
166
3-oxoacyl-[acyl-carrier-protein] synthase, KASII
2 - - 6.6
156
2 - - 9.5
185
BIOTIN PIMELOYL-COA SYNTHESIS PROTEIN
2 - - 7.7
164
2 - - 0.0
196
Polyketide synthase, putative
JCVI
2 - - 0.0
206
1 - - 0.0
220
1 - - 0.0
226
1 - - 0.0
211
1 - - 0.0
236
1 - - 0.0
218
1 - - 0.0
285
1 - - 0.0
234
1 - - 0.0
288
1 - - 0.0
244
1 - - 0.0
246
1 - - 0.0
295
1 - - 0.0
221
1 - - 0.0
260
1 - - 0.0
237
1 - - 0.0
309
Polyketide synthase/nonribosomal peptide synthetase hybrid RzxB
1 - - 0.0
300
1 - - 0.0
286
1 - - 0.0
308
Polyketide synthase/nonribosomal peptide synthetase hybrid RzxA
1 - - 0.0
254
1 - - 0.0
205
1 - - 0.0
235
1 - - 0.0
301
1 - - 0.0
213
1 - - 0.0
296
1 - - 0.0
265
1 - - 0.0
272
1 - - 0.0
287
1 - - 0.0
294
1 - - 0.0
275
1 - - 0.0
224
1 - - 0.0
262
1 - - 0.0
212
1 - - 0.0
251
Uncharacterized protein
1 - - 0.0
279
1 - - 0.0
256
1 - - 0.0
227
1 - - 0.0
264
1 - - 0.0
255
1 - - 0.0
232
1 - - 0.0
225
1 - - 0.0
207
1 - - 0.0
263
1 - - 0.0
293
1 - - 0.0
274
1 - - 0.0
310
Polyketide synthase
1 - - 0.0
250
3-hydroxy-3-methylglutaryl coenzyme A synthase
1 - - 0.0
303
1 - - 0.0
215
1 - - 0.0
278
1 - - 0.0
245
1 - - 0.0
267
1 - - 0.0
257
1 - - 0.0
276
1 - - 0.0
233
1 - - 0.0
259
1 - - 0.0
208
1 - - 0.0
292
1 - - 0.0
291
1 - - 0.0
241
1 - - 0.0
280
1 - - 0.0
273
1 - - 0.0
249
Uncharacterized protein
1 - - 0.0
202
1 - - 0.0
307
Polyketide synthase RzxD
1 - - 0.0
270
1 - - 0.0
240
1 - - 0.0
230
1 - - 0.0
299
1 - - 0.0
201
1 - - 0.0
266
1 - - 0.0
214
1 - - 0.0
302
1 - - 0.0
229
1 - - 0.0
222
1 - - 0.0
305
Polyketide synthase
1 - - 0.0
217
1 - - 0.0
239
1 - - 0.0
281
Gll2853 protein
1 - - 0.0
269
1 - - 0.0
298
1 - - 0.0
243
1 - - 0.0
231
1 - - 0.0
203
1 - - 0.0
261
1 - - 0.0
284
1 - - 0.0
247
3-oxoacyl-[acyl-carrier-protein] synthase
1 - - 0.0
204
1 - - 0.0
289
1 - - 0.0
228
1 - - 0.0
268
1 - - 0.0
223
1 - - 0.0
282
1 - - 0.0
238
1 - - 0.0
253
Uncharacterized protein
1 - - 0.0
209
1 - - 0.0
216
1 - - 0.0
297
1 - - 0.0
277
1 - - 0.0
290
1 - - 0.0
304
Sterigmatocystin biosynthesis fatty acid synthase subunit alpha
1 - - 0.0
210
1 - - 0.0
258
1 - - 0.0
306
Probable polyketide synthase 37
1 - - 0.0
252
Acetyl-CoA C-acyltransferase
1 - - 0.0
283
1 - - 0.0
271
1 - - 0.0
219
1 - - 0.0
248
Uncharacterized protein
1 - - 0.0
242
1 - - 0.0
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