CATH Domain 1u0mB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.47	Peroxisomal Thiolase; Chain A, domain 1
	3.40.47.10	Thiolase/Chalcone synthase

Domain Context

CATH Clusters

Superfamily	3.40.47.10
Functional Family	Type III polyketide synthase

Enzyme Information

2.3.1.233

1,3,6,8-tetrahydroxynaphthalene synthase.

based on mapping to UniProt Q9FCA7

5 malonyl-CoA = 1,3,6,8-tetrahydroxynaphthalene + 5 CoA + 5 CO(2) + H(2)O.

-!- Isolated from the fungus Colletotrichum lagenarium, and the bacteria Streptomyces coelicolor and Streptomyces peucetius. -!- It only uses malonyl-CoA, without invovement of acetyl-CoA.

UniProtKB Entries (1)

Q9FCA7

RPPA_STRCO

Streptomyces coelicolor A3(2)

1,3,6,8-tetrahydroxynaphthalene synthase

PDB Structure

PDB	1U0M
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates Austin, M.B., Izumikawa, M., Bowman, M.E., Udwary, D.W., Ferrer, J.L., Moore, B.S., Noel, J.P. J.Biol.Chem.