The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
CRAL-TRIO lipid binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Alpha-tocopherol transfer protein-like

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphatidylinositol-3,5-bisphosphate binding GO:0080025
Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.
45 A6JFQ6 (/ISS) A6JUQ6 (/ISS) Q5M7E1 (/ISS) Q5M7E1 (/ISS) Q5RCA6 (/ISS) Q5RCA6 (/ISS) Q5SPP0 (/ISS) Q5SPP0 (/ISS) Q8BG92 (/ISS) Q95KF7 (/ISS)
(35 more)
Phosphatidylinositol-3,5-bisphosphate binding GO:0080025
Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.
38 Q5SYC1 (/IDA) Q5SYC1 (/IDA) Q5SYC1 (/IDA) Q5SYC1 (/IDA) Q5SYC1 (/IDA) Q5SYC1 (/IDA) Q5SYC1 (/IDA) Q5SYC1 (/IDA) Q5SYC1 (/IDA) Q5SYC1 (/IDA)
(28 more)
Vitamin E binding GO:0008431
Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.
4 P49638 (/TAS) P49638 (/TAS) Q8BWP5 (/TAS) Q8BWP5 (/TAS)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
3 P41034 (/ISS) P49638 (/ISS) P49638 (/ISS)
Vitamin E binding GO:0008431
Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.
3 P41034 (/IDA) Q8BWP5 (/IDA) Q8BWP5 (/IDA)
Phosphatidylinositol-3,4-bisphosphate binding GO:0043325
Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.
3 P41034 (/ISS) P49638 (/ISS) P49638 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P49638 (/IPI) P49638 (/IPI)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
2 Q8BWP5 (/IDA) Q8BWP5 (/IDA)
Vitamin E binding GO:0008431
Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.
2 Q8BWP5 (/ISO) Q8BWP5 (/ISO)
Vitamin E binding GO:0008431
Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.
2 P49638 (/ISS) P49638 (/ISS)
Vitamin binding GO:0019842
Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
2 Q8BWP5 (/ISO) Q8BWP5 (/ISO)
Phosphatidylinositol-3,4-bisphosphate binding GO:0043325
Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.
2 Q8BWP5 (/IDA) Q8BWP5 (/IDA)
Phosphatidylinositol-3,5-bisphosphate binding GO:0080025
Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.
2 Q8BG92 (/ISO) Q9D4C9 (/ISO)
Lipid transfer activity GO:0120013
Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
2 Q8BWP5 (/IDA) Q8BWP5 (/IDA)
Vitamin binding GO:0019842
Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
1 P41034 (/IDA)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lysosome organization GO:0007040
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
81 Q5M7E1 (/ISS) Q5M7E1 (/ISS) Q5RCA6 (/ISS) Q5RCA6 (/ISS) Q5SPP0 (/ISS) Q5SPP0 (/ISS) Q5SYC1 (/ISS) Q5SYC1 (/ISS) Q5SYC1 (/ISS) Q5SYC1 (/ISS)
(71 more)
Optokinetic behavior GO:0007634
The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus.
3 F1QVD3 (/IMP) Q6P027 (/IMP) Q6PC74 (/IMP)
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
3 F1QVD3 (/IMP) Q6P027 (/IMP) Q6PC74 (/IMP)
Vitamin transport GO:0051180
The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
3 P41034 (/ISS) P49638 (/ISS) P49638 (/ISS)
Intermembrane lipid transfer GO:0120009
The transport of lipids between membranes in which a lipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs).
3 P41034 (/ISS) P49638 (/ISS) P49638 (/ISS)
Placenta development GO:0001890
The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
2 Q8BWP5 (/IMP) Q8BWP5 (/IMP)
Embryonic placenta development GO:0001892
The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
2 Q8BWP5 (/IMP) Q8BWP5 (/IMP)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
2 P49638 (/TAS) P49638 (/TAS)
Lysosome organization GO:0007040
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
2 A6JFQ6 (/IMP) A6JUQ6 (/IMP)
Response to pH GO:0009268
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
2 Q8BWP5 (/ISO) Q8BWP5 (/ISO)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
2 Q8BWP5 (/IMP) Q8BWP5 (/IMP)
Vitamin E metabolic process GO:0042360
The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.
2 Q8BWP5 (/IMP) Q8BWP5 (/IMP)
Vitamin E metabolic process GO:0042360
The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.
2 Q8BWP5 (/ISO) Q8BWP5 (/ISO)
Vitamin E metabolic process GO:0042360
The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.
2 P49638 (/TAS) P49638 (/TAS)
Vitamin transport GO:0051180
The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
2 Q8BWP5 (/IDA) Q8BWP5 (/IDA)
Intracellular pH reduction GO:0051452
Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion.
2 Q8BWP5 (/ISO) Q8BWP5 (/ISO)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
2 Q8BWP5 (/ISO) Q8BWP5 (/ISO)
Negative regulation of establishment of blood-brain barrier GO:0090212
Any process that decreases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain.
2 Q8BWP5 (/IMP) Q8BWP5 (/IMP)
Intermembrane lipid transfer GO:0120009
The transport of lipids between membranes in which a lipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs).
2 Q8BWP5 (/IDA) Q8BWP5 (/IDA)
Lysosome organization GO:0007040
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
1 Q9D4C9 (/ISO)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
1 B0S5J5 (/IMP)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
1 P41034 (/IEP)
Response to pH GO:0009268
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
1 P41034 (/IDA)
Developmental process GO:0032502
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
1 P41034 (/IEP)
Vitamin E metabolic process GO:0042360
The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.
1 P41034 (/IDA)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
1 B0S5J5 (/IMP)
Intracellular pH reduction GO:0051452
Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion.
1 P41034 (/IDA)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 P41034 (/IDA)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
81 Q5M7E1 (/ISS) Q5M7E1 (/ISS) Q5RCA6 (/ISS) Q5RCA6 (/ISS) Q5SPP0 (/ISS) Q5SPP0 (/ISS) Q5SYC1 (/ISS) Q5SYC1 (/ISS) Q5SYC1 (/ISS) Q5SYC1 (/ISS)
(71 more)
Clathrin-coated vesicle GO:0030136
A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
81 Q5M7E1 (/ISS) Q5M7E1 (/ISS) Q5RCA6 (/ISS) Q5RCA6 (/ISS) Q5SPP0 (/ISS) Q5SPP0 (/ISS) Q5SYC1 (/ISS) Q5SYC1 (/ISS) Q5SYC1 (/ISS) Q5SYC1 (/ISS)
(71 more)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
45 A6JFQ6 (/ISS) A6JUQ6 (/ISS) Q5M7E1 (/ISS) Q5M7E1 (/ISS) Q5RCA6 (/ISS) Q5RCA6 (/ISS) Q5SPP0 (/ISS) Q5SPP0 (/ISS) Q8BG92 (/ISS) Q95KF7 (/ISS)
(35 more)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
38 Q5SYC1 (/IDA) Q5SYC1 (/IDA) Q5SYC1 (/IDA) Q5SYC1 (/IDA) Q5SYC1 (/IDA) Q5SYC1 (/IDA) Q5SYC1 (/IDA) Q5SYC1 (/IDA) Q5SYC1 (/IDA) Q5SYC1 (/IDA)
(28 more)
Trans-Golgi network membrane GO:0032588
The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.
38 Q5SYC1 (/TAS) Q5SYC1 (/TAS) Q5SYC1 (/TAS) Q5SYC1 (/TAS) Q5SYC1 (/TAS) Q5SYC1 (/TAS) Q5SYC1 (/TAS) Q5SYC1 (/TAS) Q5SYC1 (/TAS) Q5SYC1 (/TAS)
(28 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q8BWP5 (/TAS) Q8BWP5 (/TAS)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
2 Q8BG92 (/ISO) Q9D4C9 (/ISO)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
2 Q8BWP5 (/ISO) Q8BWP5 (/ISO)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
2 A6JFQ6 (/IDA) A6JUQ6 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q8BWP5 (/ISO) Q8BWP5 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P49638 (/TAS) P49638 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q9BTX7 (/HDA) Q9BTX7 (/HDA)
Clathrin-coated vesicle GO:0030136
A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
2 A6JFQ6 (/IDA) A6JUQ6 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9VM12 (/HDA)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
1 P41034 (/IDA)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
1 Q9D4C9 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P41034 (/IDA)
Clathrin-coated vesicle GO:0030136
A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
1 Q9D4C9 (/ISO)
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