The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18: DNA-binding transcriptional regulator NtrC

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphorelay response regulator activity GO:0000156
Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.
99 Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS)
(89 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
57 P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI) P0AFB8 (/IPI)
(47 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
19 I7CA98 (/IPI) I7CA98 (/IPI) I7CA98 (/IPI) P10958 (/IPI) P10958 (/IPI) P10958 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI)
(9 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
19 I7CA98 (/IPI) I7CA98 (/IPI) I7CA98 (/IPI) P10958 (/IPI) P10958 (/IPI) P10958 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI)
(9 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
16 I7CA98 (/IMP) I7CA98 (/IMP) I7CA98 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP)
(6 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
9 I7CA98 (/IMP) I7CA98 (/IMP) I7CA98 (/IMP) Q9KQ67 (/IMP) Q9KQ67 (/IMP) Q9KQ67 (/IMP) Q9KQ67 (/IMP) Q9KQ67 (/IMP) Q9KQ67 (/IMP)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
7 Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
7 Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
3 I7CA98 (/IDA) I7CA98 (/IDA) I7CA98 (/IDA)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
3 I7CA98 (/IDA) I7CA98 (/IDA) I7CA98 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 Q5LKZ2 (/ISS) Q5LS76 (/ISS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q2GHC4 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O30989 (/IPI)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphorelay signal transduction system GO:0000160
A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
99 Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS)
(89 more)
Regulation of nitrogen utilization GO:0006808
Any process that modulates the frequency, rate or extent of nitrogen utilization.
95 Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS) Q48CE7 (/ISS)
(85 more)
Positive regulation of organic acid transport GO:0032892
Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
10 Q9HU19 (/IMP) Q9HU19 (/IMP) Q9HU19 (/IMP) Q9HU19 (/IMP) Q9HU19 (/IMP) Q9HU19 (/IMP) Q9HU19 (/IMP) Q9HU19 (/IMP) Q9HU19 (/IMP) Q9HU19 (/IMP)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
9 Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP)
Negative regulation of single-species biofilm formation GO:1900191
Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation.
9 Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP)
Positive regulation of cilium-dependent cell motility GO:2000155
Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility.
9 Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP) Q9I4N3 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
8 P03029 (/IMP) P03029 (/IMP) P03029 (/IMP) P03029 (/IMP) P03029 (/IMP) P03029 (/IMP) P03029 (/IMP) P03029 (/IMP)
Positive regulation of single-species biofilm formation on inanimate substrate GO:1900233
Any process that activates or increases the frequency, rate or extent of single-species biofilm formation on inanimate substrate.
8 Q9HT62 (/IMP) Q9HT62 (/IMP) Q9HT62 (/IMP) Q9HT62 (/IMP) Q9HT62 (/IMP) Q9HT62 (/IMP) Q9HT62 (/IMP) Q9HT62 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
7 Q88CY1 (/IDA) Q88CY1 (/IDA) Q88CY1 (/IDA) Q88CY1 (/IDA) Q88CY1 (/IDA) Q88CY1 (/IDA) Q88CY1 (/IDA)
C4-dicarboxylate transport GO:0015740
The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms.
4 Q5LKZ2 (/ISS) Q5LQ67 (/ISS) Q5LS76 (/ISS) Q8ECK1 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
4 P10958 (/IEP) P10958 (/IEP) P10958 (/IEP) Q74D24 (/IEP)
Nitrogen fixation GO:0009399
The process in which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide.
2 Q5LRP0 (/ISS) Q603F8 (/ISS)
Nitrogen utilization GO:0019740
A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism.
2 Q74EZ8 (/ISS) Q74EZ8 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q2GHC4 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q5LQ67 (/ISS)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
57 P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA) P0AFB8 (/IDA)
(47 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
19 I7CA98 (/IPI) I7CA98 (/IPI) I7CA98 (/IPI) P10958 (/IPI) P10958 (/IPI) P10958 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI) Q88CY1 (/IPI)
(9 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
16 I7CA98 (/IMP) I7CA98 (/IMP) I7CA98 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP) Q88CY1 (/IMP)
(6 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
3 I7CA98 (/IDA) I7CA98 (/IDA) I7CA98 (/IDA)
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