The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"alpha/beta hydrolase
".
FunFam 11: Carboxylic ester hydrolase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 13 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Carboxylic ester hydrolase activity GO:0052689
Catalysis of the hydrolysis of a carboxylic ester bond.
|
10 | F7F3M3 (/IDA) O00748 (/IDA) P10959 (/IDA) P23953 (/IDA) Q64176 (/IDA) Q64176 (/IDA) Q8BK48 (/IDA) Q8K3R0 (/IDA) Q8QZR3 (/IDA) Q8VCT4 (/IDA) |
Carboxylic ester hydrolase activity GO:0052689
Catalysis of the hydrolysis of a carboxylic ester bond.
|
6 | O00748 (/TAS) P16303 (/TAS) P23141 (/TAS) Q63108 (/TAS) Q6UWW8 (/TAS) Q8VCT4 (/TAS) |
Sterol esterase activity GO:0004771
Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid.
|
2 | P23141 (/IDA) Q8VCT4 (/IDA) |
Palmitoyl-CoA hydrolase activity GO:0016290
Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate.
|
2 | Q64176 (/ISO) Q64176 (/ISO) |
Carboxylic ester hydrolase activity GO:0052689
Catalysis of the hydrolysis of a carboxylic ester bond.
|
2 | P16303 (/IMP) Q8VCT4 (/IMP) |
Carboxylic ester hydrolase activity GO:0052689
Catalysis of the hydrolysis of a carboxylic ester bond.
|
2 | F6Z9B9 (/ISO) Q8VCT4 (/ISO) |
Sterol esterase activity GO:0004771
Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid.
|
1 | Q8VCT4 (/ISO) |
Sterol esterase activity GO:0004771
Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid.
|
1 | P16303 (/ISS) |
Triglyceride lipase activity GO:0004806
Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
|
1 | Q8VCT4 (/IDA) |
Triglyceride lipase activity GO:0004806
Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
|
1 | P16303 (/ISS) |
Palmitoyl-CoA hydrolase activity GO:0016290
Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate.
|
1 | Q63108 (/IDA) |
Hydrolase activity, acting on ester bonds GO:0016788
Catalysis of the hydrolysis of any ester bond.
|
1 | P23953 (/IDA) |
Acylcarnitine hydrolase activity GO:0047619
Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine.
|
1 | Q91WG0 (/IDA) |
There are 29 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
|
3 | O00748 (/TAS) P23141 (/TAS) Q6UWW8 (/TAS) |
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
|
3 | P23953 (/IEP) Q8VCC2 (/IEP) Q8VCC2 (/IEP) |
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
|
2 | F7F3M3 (/TAS) Q8K3R0 (/TAS) |
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
|
2 | P23141 (/TAS) Q8VCT4 (/TAS) |
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q8VCC2 (/IMP) Q8VCC2 (/IMP) |
Short-chain fatty acid catabolic process GO:0019626
The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than C6.
|
2 | Q8VCT4 (/IDA) Q91WU0 (/IDA) |
Chylomicron assembly GO:0034378
The non-covalent aggregation and arrangement of proteins and lipids in the intestine to form a chylomicron.
|
2 | Q8VCC2 (/IMP) Q8VCC2 (/IMP) |
Regulation of triglyceride metabolic process GO:0090207
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol.
|
2 | Q8VCC2 (/IMP) Q8VCC2 (/IMP) |
Regulation of chylomicron remnant clearance GO:0090320
Any process that modulates the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded.
|
2 | Q8VCC2 (/IMP) Q8VCC2 (/IMP) |
Angiotensin maturation GO:0002003
The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood.
|
1 | P23141 (/TAS) |
Protein glycosylation GO:0006486
A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
|
1 | Q8QZR3 (/IDA) |
Acyl-CoA metabolic process GO:0006637
The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.
|
1 | Q8VCT4 (/TAS) |
Prostaglandin metabolic process GO:0006693
The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.
|
1 | O00748 (/IDA) |
Prostaglandin metabolic process GO:0006693
The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.
|
1 | F6Z9B9 (/ISO) |
Cholesterol biosynthetic process GO:0006695
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
1 | P23141 (/IDA) |
Cholesterol biosynthetic process GO:0006695
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
1 | Q8VCT4 (/ISO) |
Catabolic process GO:0009056
The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
|
1 | O00748 (/TAS) |
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
|
1 | Q32Q55 (/IEP) |
Lipid catabolic process GO:0016042
The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
|
1 | Q8VCT4 (/IDA) |
Lipid catabolic process GO:0016042
The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
|
1 | Q8VCT4 (/NAS) |
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
|
1 | P23141 (/IDA) |
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
|
1 | Q8VCT4 (/ISO) |
Very-low-density lipoprotein particle assembly GO:0034379
The non-covalent aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle.
|
1 | Q8VCT4 (/IMP) |
Low-density lipoprotein particle clearance GO:0034383
The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
|
1 | Q6UWW8 (/TAS) |
Acylglycerol catabolic process GO:0046464
The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.
|
1 | Q8VCT4 (/IDA) |
Acylglycerol catabolic process GO:0046464
The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.
|
1 | P16303 (/ISS) |
Medium-chain fatty acid metabolic process GO:0051791
The chemical reactions and pathways involving medium-chain fatty acids, any fatty acid with a chain length of between C6 and C12.
|
1 | P23141 (/IDA) |
Medium-chain fatty acid metabolic process GO:0051791
The chemical reactions and pathways involving medium-chain fatty acids, any fatty acid with a chain length of between C6 and C12.
|
1 | Q8VCT4 (/ISO) |
Cholesterol ester hydrolysis involved in cholesterol transport GO:0090122
The cholesterol metabolic process in which cholesterol esters are hydrolyzed into free fatty acids and cholesterol in the lysosome that contributes to intracellular cholesterol transport.
|
1 | P23141 (/TAS) |
There are 16 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
|
3 | A0A2R8QSI8 (/IDA) Q1LUZ9 (/IDA) Q5BJI3 (/IDA) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
3 | F7F3M3 (/IDA) Q8K3R0 (/IDA) Q91WG0 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
2 | O00748 (/TAS) Q8VCT4 (/TAS) |
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
|
2 | O00748 (/TAS) P23141 (/TAS) |
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
|
2 | Q8VCT4 (/IDA) Q91WU0 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q8VCT4 (/IDA) Q91WU0 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
2 | Q6IPK9 (/HDA) Q6UWW8 (/HDA) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P23953 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | P23141 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | Q8VCT4 (/ISO) |
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
|
1 | Q8VCT4 (/IDA) |
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
|
1 | P16303 (/ISS) |
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
|
1 | P16303 (/NAS) |
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
|
1 | P16303 (/ISS) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P16303 (/ISS) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q6UWW8 (/TAS) |