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CATH Superfamily 3.40.50.1820

Alpha/Beta hydrolase fold, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
alpha/beta hydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Carboxylic ester hydrolase

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Carboxylesterase. [EC: 3.1.1.1]
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
  • Wide specificity; also hydrolyzes vitamin A esters.
  • The enzymes from microsomes also catalyze the reactions of EC 3.1.1.2, EC 3.1.1.5, EC 3.1.1.6, EC 3.1.1.23, EC 3.1.1.28, EC 3.1.2.2, EC 3.5.1.4 and EC 3.5.1.13.
  • Formerly EC 3.1.1.12.
 32 A0A480T2R7 A0A480T2R7 O00748 O46421 P10959 P16303 P23141 P23953 Q29550 Q29550
(22 more...)
Fatty-acyl-ethyl-ester synthase. [EC: 3.1.1.67]
A long-chain-fatty-acyl ethyl ester + H(2)O = a long-chain-fatty acid + ethanol.
  • In the reverse reaction, forms ethyl esters from fatty acids and ethanol in the absence of coenzyme A or ATP.
  • Best substrates are unsaturated octadecanoic acids; palmitate, stearate and arachidonate also act, more slowly.
 2 P16303 Q8VCT4
Pyrethroid hydrolase. [EC: 3.1.1.88]
Trans-permethrin + H(2)O = (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2- dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate.
  • The enzyme is involved in degradation of pyrethroid pesticides.
  • The enzymes from Sphingobium sp., Klebsiella sp. and Aspergillus niger hydrolyze cis-permethrin at approximately equal rate to trans- permethrin.
  • The enzyme from mouse hydrolyzes trans-permethrin at a rate about 22-fold higher than cis-permethrin.
 2 Q8BK48 Q8QZR3
Methylumbelliferyl-acetate deacetylase. [EC: 3.1.1.56]
4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate.
  • Acts on short-chain acyl esters of 4-methylumbelliferone, but not on naphthyl, indoxyl or thiocholine esters.
 2 O00748 P23141
Acylcarnitine hydrolase. [EC: 3.1.1.28]
O-acylcarnitine + H(2)O = a fatty acid + L-carnitine.
  • Acts on higher fatty acid (C(6) to C(18)) esters of L-carnitine.
  • Highest activity is with O-decanoyl-L-carnitine.
 1 Q91WG0
Cocaine esterase. [EC: 3.1.1.84]
Cocaine + H(2)O = ecgonine methyl ester + benzoate.
  • Rhodococcus sp. strain MB1 and Pseudomonas maltophilia strain MB11L can utilize cocaine as sole source of carbon and energy.
 1 O00748
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