The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 1: 3-ketoacyl-CoA thiolase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Acetyl-CoA C-acyltransferase activity GO:0003988
Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
|
20 |
P13437 (/IDA)
P21151 (/IDA)
P21151 (/IDA)
P21151 (/IDA)
P21151 (/IDA)
P21151 (/IDA)
P21151 (/IDA)
P21151 (/IDA)
P21151 (/IDA)
P21151 (/IDA)
(10 more) |
Acetyl-CoA C-acetyltransferase activity GO:0003985
Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
|
15 |
Q5RES5 (/ISS)
Q81Y70 (/ISS)
Q81Y70 (/ISS)
Q81Y70 (/ISS)
Q81Y70 (/ISS)
Q81Y70 (/ISS)
Q81Y70 (/ISS)
Q8BWT1 (/ISS)
Q8EGC7 (/ISS)
Q9KLQ2 (/ISS)
(5 more) |
Acetyl-CoA C-acyltransferase activity GO:0003988
Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
|
10 | Q46939 (/IMP) Q46939 (/IMP) Q46939 (/IMP) Q46939 (/IMP) Q46939 (/IMP) Q46939 (/IMP) Q46939 (/IMP) Q46939 (/IMP) Q46939 (/IMP) Q46939 (/IMP) |
Acetyl-CoA C-acyltransferase activity GO:0003988
Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
|
10 | Q5RES5 (/ISS) Q8BWT1 (/ISS) Q8EKS0 (/ISS) Q9KNI0 (/ISS) Q9KNI0 (/ISS) Q9KNI0 (/ISS) Q9KNI0 (/ISS) Q9KNI0 (/ISS) Q9KNI0 (/ISS) Q9VL70 (/ISS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P28790 (/IPI) P28790 (/IPI) P42765 (/IPI) |
Acyl-CoA hydrolase activity GO:0047617
Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
|
2 | Q5RES5 (/ISS) Q8BWT1 (/ISS) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | P42765 (/HDA) |
Acetyl-CoA C-acetyltransferase activity GO:0003985
Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.
|
1 | P42765 (/IDA) |
Acetyl-CoA C-acyltransferase activity GO:0003988
Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
|
1 | Q8BWT1 (/ISO) |
Acetyl-CoA C-acyltransferase activity GO:0003988
Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
|
1 | P42765 (/NAS) |
Acyl-CoA hydrolase activity GO:0047617
Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
|
1 | P13437 (/IDA) |
Acyl-CoA hydrolase activity GO:0047617
Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
|
1 | P42765 (/IMP) |
There are 22 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
|
18 |
P21151 (/IMP)
P21151 (/IMP)
P21151 (/IMP)
P21151 (/IMP)
P21151 (/IMP)
P21151 (/IMP)
P21151 (/IMP)
P21151 (/IMP)
P21151 (/IMP)
P21151 (/IMP)
(8 more) |
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
|
13 |
Q81Y70 (/ISS)
Q81Y70 (/ISS)
Q81Y70 (/ISS)
Q81Y70 (/ISS)
Q81Y70 (/ISS)
Q81Y70 (/ISS)
Q8EGC7 (/ISS)
Q9KLQ2 (/ISS)
Q9KLQ2 (/ISS)
Q9KLQ2 (/ISS)
(3 more) |
1-butanol biosynthetic process GO:0071271
The chemical reactions and pathways resulting in the formation of 1-butanol, an alkyl primary alcohol with the formula C4H10O.
|
10 | Q46939 (/IMP) Q46939 (/IMP) Q46939 (/IMP) Q46939 (/IMP) Q46939 (/IMP) Q46939 (/IMP) Q46939 (/IMP) Q46939 (/IMP) Q46939 (/IMP) Q46939 (/IMP) |
Response to host immune response GO:0052572
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
8 | P9WG69 (/IEP) P9WG69 (/IEP) P9WG69 (/IEP) P9WG69 (/IEP) P9WG69 (/IEP) P9WG69 (/IEP) P9WG69 (/IEP) P9WG69 (/IEP) |
Fatty acid catabolic process GO:0009062
The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
|
7 | Q8EKS0 (/ISS) Q9KNI0 (/ISS) Q9KNI0 (/ISS) Q9KNI0 (/ISS) Q9KNI0 (/ISS) Q9KNI0 (/ISS) Q9KNI0 (/ISS) |
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901029
Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.
|
3 | P13437 (/ISS) Q5RES5 (/ISS) Q8BWT1 (/ISS) |
Lymph vessel development GO:0001945
The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.
|
2 | B0S5C5 (/IMP) Q7ZVG1 (/IMP) |
Regulation of fatty acid beta-oxidation GO:0031998
Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation.
|
2 | B0S5C5 (/IMP) Q7ZVG1 (/IMP) |
Acetyl-CoA metabolic process GO:0006084
The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
|
1 | P13437 (/IDA) |
Acetyl-CoA metabolic process GO:0006084
The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
|
1 | Q8BWT1 (/ISO) |
Energy reserve metabolic process GO:0006112
The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen.
|
1 | Q5LWU3 (/ISS) |
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
|
1 | P13437 (/IDA) |
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
|
1 | Q8BWT1 (/ISO) |
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
|
1 | Q9VL70 (/ISS) |
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
|
1 | P42765 (/TAS) |
Cholesterol biosynthetic process GO:0006695
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
1 | P42765 (/NAS) |
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | P42765 (/IDA) |
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | Q8BWT1 (/ISO) |
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901029
Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.
|
1 | P42765 (/IDA) |
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901029
Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.
|
1 | Q8BWT1 (/ISO) |
Negative regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902109
Any negative regulation of mitochondrial membrane permeability that is involved in apoptotic process.
|
1 | P42765 (/IDA) |
Negative regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902109
Any negative regulation of mitochondrial membrane permeability that is involved in apoptotic process.
|
1 | Q8BWT1 (/ISO) |
There are 14 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
8 | P9WG69 (/HDA) P9WG69 (/HDA) P9WG69 (/HDA) P9WG69 (/HDA) P9WG69 (/HDA) P9WG69 (/HDA) P9WG69 (/HDA) P9WG69 (/HDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
8 | P9WG69 (/HDA) P9WG69 (/HDA) P9WG69 (/HDA) P9WG69 (/HDA) P9WG69 (/HDA) P9WG69 (/HDA) P9WG69 (/HDA) P9WG69 (/HDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
3 | A0A0B4J2A4 (/IDA) P13437 (/IDA) P42765 (/IDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | Q5RES5 (/ISS) Q9VL70 (/ISS) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q8BWT1 (/HDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q9VL70 (/ISM) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q8BWT1 (/ISO) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P42765 (/NAS) |
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
|
1 | Q8BWT1 (/HDA) |
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
1 | P13437 (/IDA) |
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
1 | Q8BWT1 (/ISO) |
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
1 | P13437 (/NAS) |
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
1 | P42765 (/TAS) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O51136 (/IDA) |