The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Ribonuclease H-like superfamily/Ribonuclease H
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Crossover junction endodeoxyribonuclease RuvC

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
165 O25544 (/IPI) O25544 (/IPI) O25544 (/IPI) O25544 (/IPI) O25544 (/IPI) O25544 (/IPI) O25544 (/IPI) O25544 (/IPI) O25544 (/IPI) P0A814 (/IPI)
(155 more)
Crossover junction endodeoxyribonuclease activity GO:0008821
Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).
156 P0A814 (/IDA) P0A814 (/IDA) P0A814 (/IDA) P0A814 (/IDA) P0A814 (/IDA) P0A814 (/IDA) P0A814 (/IDA) P0A814 (/IDA) P0A814 (/IDA) P0A814 (/IDA)
(146 more)
Crossover junction endodeoxyribonuclease activity GO:0008821
Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).
156 P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP)
(146 more)
Crossover junction endodeoxyribonuclease activity GO:0008821
Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).
7 Q9KR00 (/ISS) Q9KR00 (/ISS) Q9KR00 (/ISS) Q9KR00 (/ISS) Q9KR00 (/ISS) Q9KR00 (/ISS) Q9KR00 (/ISS)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Recombinational repair GO:0000725
A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA.
156 P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP)
(146 more)
Response to radiation GO:0009314
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
156 P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP) P0A814 (/IMP)
(146 more)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
12 P9WGV9 (/IEP) P9WGV9 (/IEP) P9WGV9 (/IEP) P9WGV9 (/IEP) P9WGV9 (/IEP) P9WGV9 (/IEP) P9WGV9 (/IEP) P9WGV9 (/IEP) P9WGV9 (/IEP) P9WGV9 (/IEP)
(2 more)
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
7 Q9KR00 (/ISS) Q9KR00 (/ISS) Q9KR00 (/ISS) Q9KR00 (/ISS) Q9KR00 (/ISS) Q9KR00 (/ISS) Q9KR00 (/ISS)
DNA recombination GO:0006310
Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
7 Q9KR00 (/ISS) Q9KR00 (/ISS) Q9KR00 (/ISS) Q9KR00 (/ISS) Q9KR00 (/ISS) Q9KR00 (/ISS) Q9KR00 (/ISS)
SOS response GO:0009432
An error-prone process for repairing damaged microbial DNA.
7 Q92M90 (/EXP) Q92M90 (/EXP) Q92M90 (/EXP) Q92M90 (/EXP) Q92M90 (/EXP) Q92M90 (/EXP) Q9A3G6 (/EXP)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Holliday junction resolvase complex GO:0048476
An endodeoxyribonuclease complex that resolves the 4-way DNA intermediates of a Holliday junction into two separate duplex DNA molecules. Can be branch-migration associated.
156 P0A814 (/IDA) P0A814 (/IDA) P0A814 (/IDA) P0A814 (/IDA) P0A814 (/IDA) P0A814 (/IDA) P0A814 (/IDA) P0A814 (/IDA) P0A814 (/IDA) P0A814 (/IDA)
(146 more)
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