The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Ribonuclease H-like superfamily/Ribonuclease H
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: DNA polymerase III subunit epsilon

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Exonuclease activity GO:0004527
Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
12 P03007 (/IDA) P03007 (/IDA) P03007 (/IDA) P03007 (/IDA) P03007 (/IDA) P03007 (/IDA) P03007 (/IDA) P03007 (/IDA) P03007 (/IDA) P03007 (/IDA)
(2 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
12 P03007 (/IPI) P03007 (/IPI) P03007 (/IPI) P03007 (/IPI) P03007 (/IPI) P03007 (/IPI) P03007 (/IPI) P03007 (/IPI) P03007 (/IPI) P03007 (/IPI)
(2 more)
DNA-directed DNA polymerase activity GO:0003887
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
7 Q9KPX9 (/ISS) Q9KPX9 (/ISS) Q9KPX9 (/ISS) Q9KPX9 (/ISS) Q9KPX9 (/ISS) Q9KPX9 (/ISS) Q9KPX9 (/ISS)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA replication proofreading GO:0045004
Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity.
12 P03007 (/IMP) P03007 (/IMP) P03007 (/IMP) P03007 (/IMP) P03007 (/IMP) P03007 (/IMP) P03007 (/IMP) P03007 (/IMP) P03007 (/IMP) P03007 (/IMP)
(2 more)
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
7 Q9KPX9 (/ISS) Q9KPX9 (/ISS) Q9KPX9 (/ISS) Q9KPX9 (/ISS) Q9KPX9 (/ISS) Q9KPX9 (/ISS) Q9KPX9 (/ISS)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA polymerase III, core complex GO:0044776
The DNA polymerase III core complex consists of the alpha,epsilon and theta subunits and is carries out the polymerase and the 3'-5' exonuclease proofreading activities.
12 P03007 (/IDA) P03007 (/IDA) P03007 (/IDA) P03007 (/IDA) P03007 (/IDA) P03007 (/IDA) P03007 (/IDA) P03007 (/IDA) P03007 (/IDA) P03007 (/IDA)
(2 more)
DNA polymerase III complex GO:0009360
The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork.
7 Q9KPX9 (/ISS) Q9KPX9 (/ISS) Q9KPX9 (/ISS) Q9KPX9 (/ISS) Q9KPX9 (/ISS) Q9KPX9 (/ISS) Q9KPX9 (/ISS)
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