The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Neutral/alkaline non-lysosomal ceramidase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: N-acylsphingosine amidohydrolase 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
N-acylsphingosine amidohydrolase activity GO:0017040
Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine.
5 Q5W7F1 (/IDA) Q91XT9 (/IDA) Q9JHE3 (/IDA) Q9JHE3 (/IDA) Q9NR71 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
4 Q5W7F1 (/ISS) Q91XT9 (/ISS) Q9JHE3 (/ISS) Q9JHE3 (/ISS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
4 Q5W7F1 (/ISS) Q91XT9 (/ISS) Q9JHE3 (/ISS) Q9JHE3 (/ISS)
N-acylsphingosine amidohydrolase activity GO:0017040
Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine.
3 Q9JHE3 (/IMP) Q9JHE3 (/IMP) Q9NR71 (/IMP)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9JHE3 (/IPI) Q9JHE3 (/IPI)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
N-acylsphingosine amidohydrolase activity GO:0017040
Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Phytoceramidase activity GO:0070774
Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Dihydroceramidase activity GO:0071633
Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q9NR71 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q9NR71 (/IDA)
N-acylsphingosine amidohydrolase activity GO:0017040
Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine.
1 Q91XT9 (/ISS)
Phytoceramidase activity GO:0070774
Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine.
1 Q91XT9 (/IDA)
Dihydroceramidase activity GO:0071633
Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine.
1 Q91XT9 (/IDA)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sphingosine metabolic process GO:0006670
The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
4 Q5W7F1 (/ISS) Q91XT9 (/ISS) Q9JHE3 (/ISS) Q9JHE3 (/ISS)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
4 Q5W7F1 (/ISS) Q91XT9 (/ISS) Q9JHE3 (/ISS) Q9JHE3 (/ISS)
Ceramide catabolic process GO:0046514
The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid.
4 Q91XT9 (/IDA) Q9JHE3 (/IDA) Q9JHE3 (/IDA) Q9NR71 (/IDA)
Ceramide metabolic process GO:0006672
The chemical reactions and pathways involving ceramides, any N-acylated sphingoid.
3 Q91XT9 (/ISS) Q9JHE3 (/ISS) Q9JHE3 (/ISS)
Sphingosine biosynthetic process GO:0046512
The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
3 Q91XT9 (/IDA) Q9JHE3 (/IDA) Q9JHE3 (/IDA)
Sphingosine biosynthetic process GO:0046512
The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
3 Q9JHE3 (/IMP) Q9JHE3 (/IMP) Q9NR71 (/IMP)
Ceramide biosynthetic process GO:0046513
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
3 Q9JHE3 (/IMP) Q9JHE3 (/IMP) Q9NR71 (/IMP)
Ceramide biosynthetic process GO:0046513
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
3 Q5W7F1 (/ISS) Q9JHE3 (/ISS) Q9JHE3 (/ISS)
Ceramide catabolic process GO:0046514
The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid.
3 Q9JHE3 (/IMP) Q9JHE3 (/IMP) Q9NR71 (/IMP)
Negative regulation of apoptotic signaling pathway GO:2001234
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
3 Q91XT9 (/ISS) Q9JHE3 (/ISS) Q9JHE3 (/ISS)
Sphingosine metabolic process GO:0006670
The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Ceramide metabolic process GO:0006672
The chemical reactions and pathways involving ceramides, any N-acylated sphingoid.
2 Q5W7F1 (/IDA) Q9NR71 (/IDA)
Ceramide metabolic process GO:0006672
The chemical reactions and pathways involving ceramides, any N-acylated sphingoid.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Lipid digestion GO:0044241
The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.
2 Q9JHE3 (/IMP) Q9JHE3 (/IMP)
Lipid digestion GO:0044241
The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.
2 Q91XT9 (/ISS) Q9NR71 (/ISS)
Sphingosine biosynthetic process GO:0046512
The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Ceramide biosynthetic process GO:0046513
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
2 Q91XT9 (/IDA) Q9NR71 (/IDA)
Ceramide biosynthetic process GO:0046513
The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Ceramide catabolic process GO:0046514
The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Negative regulation of apoptotic signaling pathway GO:2001234
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Sphingosine metabolic process GO:0006670
The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
1 Q9NR71 (/IDA)
Sphingosine metabolic process GO:0006670
The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
1 Q9NR71 (/IMP)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
1 Q9NR71 (/IMP)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 Q91XT9 (/IDA)
Sphingosine biosynthetic process GO:0046512
The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
1 Q5W7F1 (/ISS)
Ceramide catabolic process GO:0046514
The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid.
1 Q5W7F1 (/ISS)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
1 Q9NR71 (/IDA)
Negative regulation of apoptotic signaling pathway GO:2001234
Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
1 Q9NR71 (/IMP)

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 Q5W7F1 (/IDA) Q91XT9 (/IDA) Q9JHE3 (/IDA) Q9JHE3 (/IDA) Q9NR71 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 Q91XT9 (/IDA) Q9JHE3 (/IDA) Q9JHE3 (/IDA) Q9NR71 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 Q91XT9 (/IDA) Q9JHE3 (/IDA) Q9JHE3 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
3 Q91XT9 (/ISS) Q9JHE3 (/ISS) Q9JHE3 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 Q91XT9 (/IDA) Q9JHE3 (/IDA) Q9JHE3 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 Q91XT9 (/ISS) Q9JHE3 (/ISS) Q9JHE3 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q9JHE3 (/HDA) Q9JHE3 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q5W7F1 (/ISS) Q9NR71 (/ISS)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
2 Q9JHE3 (/IDA) Q9JHE3 (/IDA)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
2 Q91XT9 (/ISS) Q9NR71 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q9JHE3 (/IDA) Q9JHE3 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q9JHE3 (/ISO) Q9JHE3 (/ISO)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
1 Q5W7F1 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q5W7F1 (/ISS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q5W7F1 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q9NR71 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q5W7F1 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q9NR71 (/IDA)
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