The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Nascent polypeptide-associated complex domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Nascent polypeptide-associated complex (NAC), alph...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
52 P38879 (/IPI) P38879 (/IPI) P38879 (/IPI) P38879 (/IPI) P38879 (/IPI) P38879 (/IPI) P38879 (/IPI) P38879 (/IPI) P38879 (/IPI) P38879 (/IPI)
(42 more)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
42 Q13765 (/NAS) Q13765 (/NAS) Q13765 (/NAS) Q13765 (/NAS) Q13765 (/NAS) Q13765 (/NAS) Q13765 (/NAS) Q13765 (/NAS) Q13765 (/NAS) Q13765 (/NAS)
(32 more)
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
10 P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
10 P38879 (/IMP) P38879 (/IMP) P38879 (/IMP) P38879 (/IMP) P38879 (/IMP) P38879 (/IMP) P38879 (/IMP) P38879 (/IMP) P38879 (/IMP) P38879 (/IMP)
Phosphatidylinositol-4-phosphate binding GO:0070273
Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
10 P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA)
Phosphatidic acid binding GO:0070300
Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
10 P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA)
Phosphatidylinositol-3,5-bisphosphate binding GO:0080025
Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.
10 P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
5 P70670 (/IDA) Q60817 (/IDA) Q60817 (/IDA) Q60817 (/IDA) Q60817 (/IDA)
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
5 P70670 (/IDA) Q60817 (/IDA) Q60817 (/IDA) Q60817 (/IDA) Q60817 (/IDA)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
2 Q2HYP8 (/ISS) Q5E9A1 (/ISS)
TBP-class protein binding GO:0017025
Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
2 Q2HYP8 (/ISS) Q5E9A1 (/ISS)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
1 Q54U07 (/ISS)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cardiac ventricle development GO:0003231
The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
42 Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS)
(32 more)
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
42 Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS)
(32 more)
Negative regulation of striated muscle cell apoptotic process GO:0010664
Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.
42 Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS)
(32 more)
Skeletal muscle tissue regeneration GO:0043403
The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.
42 Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS)
(32 more)
Positive regulation of skeletal muscle tissue growth GO:0048633
Any process that activates, maintains or increases the rate of skeletal muscle growth.
42 Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS)
(32 more)
Regulation of skeletal muscle fiber development GO:0048742
Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
42 Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS)
(32 more)
Heart trabecula morphogenesis GO:0061384
The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.
42 Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS)
(32 more)
Negative regulation of transcription from RNA polymerase II promoter involved in heart development GO:1901227
Any negative regulation of transcription from RNA polymerase II promoter that is involved in heart development.
42 Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS)
(32 more)
Positive regulation of transcription from RNA polymerase II promoter involved in heart development GO:1901228
Any positive regulation of transcription from RNA polymerase II promoter that is involved in heart development.
42 Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS)
(32 more)
Positive regulation of cell proliferation involved in heart morphogenesis GO:2000138
Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis.
42 Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS) Q13765 (/ISS)
(32 more)
'de novo' cotranslational protein folding GO:0051083
The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated.
12 C6KT55 (/ISS) C6KT55 (/ISS) C6KT55 (/ISS) C6KT55 (/ISS) C6KT55 (/ISS) C6KT55 (/ISS) C6KT55 (/ISS) C6KT55 (/ISS) C6KT55 (/ISS) C6KT55 (/ISS)
(2 more)
Posttranslational protein targeting to endoplasmic reticulum membrane GO:0006620
The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.
10 P38879 (/IGI) P38879 (/IGI) P38879 (/IGI) P38879 (/IGI) P38879 (/IGI) P38879 (/IGI) P38879 (/IGI) P38879 (/IGI) P38879 (/IGI) P38879 (/IGI)
'de novo' cotranslational protein folding GO:0051083
The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated.
10 P38879 (/IPI) P38879 (/IPI) P38879 (/IPI) P38879 (/IPI) P38879 (/IPI) P38879 (/IPI) P38879 (/IPI) P38879 (/IPI) P38879 (/IPI) P38879 (/IPI)
Myoblast migration GO:0051451
The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
5 P70670 (/IMP) Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP)
Cardiac ventricle development GO:0003231
The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
4 Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP)
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
4 Q38EE8 (/IDA) Q38EE8 (/IDA) Q38EE8 (/IDA) Q38EE8 (/IDA)
Negative regulation of striated muscle cell apoptotic process GO:0010664
Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.
4 Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP)
Skeletal muscle tissue regeneration GO:0043403
The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.
4 Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP)
Positive regulation of skeletal muscle tissue growth GO:0048633
Any process that activates, maintains or increases the rate of skeletal muscle growth.
4 Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP)
Regulation of skeletal muscle fiber development GO:0048742
Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
4 Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP)
Heart trabecula morphogenesis GO:0061384
The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.
4 Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP)
Negative regulation of transcription from RNA polymerase II promoter involved in heart development GO:1901227
Any negative regulation of transcription from RNA polymerase II promoter that is involved in heart development.
4 Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter involved in heart development GO:1901228
Any positive regulation of transcription from RNA polymerase II promoter that is involved in heart development.
4 Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP)
Positive regulation of cell proliferation involved in heart morphogenesis GO:2000138
Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis.
4 Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP) Q60817 (/IMP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
3 Q6ICZ8 (/IEP) Q9LHG9 (/IEP) Q9LHG9 (/IEP)
Myofibril assembly GO:0030239
Formation of myofibrils, the repeating units of striated muscle.
2 Q8JIU7 (/IMP) Q8JIU7 (/IMP)
Definitive hemopoiesis GO:0060216
A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood.
2 Q8JIU7 (/IMP) Q8JIU7 (/IMP)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
42 Q13765 (/NAS) Q13765 (/NAS) Q13765 (/NAS) Q13765 (/NAS) Q13765 (/NAS) Q13765 (/NAS) Q13765 (/NAS) Q13765 (/NAS) Q13765 (/NAS) Q13765 (/NAS)
(32 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
42 Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS)
(32 more)
Nascent polypeptide-associated complex GO:0005854
A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome.
42 Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS) Q13765 (/TAS)
(32 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
42 Q13765 (/HDA) Q13765 (/HDA) Q13765 (/HDA) Q13765 (/HDA) Q13765 (/HDA) Q13765 (/HDA) Q13765 (/HDA) Q13765 (/HDA) Q13765 (/HDA) Q13765 (/HDA)
(32 more)
Nascent polypeptide-associated complex GO:0005854
A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome.
12 C6KT55 (/ISS) C6KT55 (/ISS) C6KT55 (/ISS) C6KT55 (/ISS) C6KT55 (/ISS) C6KT55 (/ISS) C6KT55 (/ISS) C6KT55 (/ISS) C6KT55 (/ISS) C6KT55 (/ISS)
(2 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
11 P70670 (/IDA) Q38EE8 (/IDA) Q38EE8 (/IDA) Q38EE8 (/IDA) Q38EE8 (/IDA) Q60817 (/IDA) Q60817 (/IDA) Q60817 (/IDA) Q60817 (/IDA) Q8JIU7 (/IDA)
(1 more)
Nascent polypeptide-associated complex GO:0005854
A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome.
10 P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA) P38879 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 P70670 (/IDA) Q60817 (/IDA) Q60817 (/IDA) Q60817 (/IDA) Q60817 (/IDA) Q8JIU7 (/IDA) Q8JIU7 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 Q6ICZ8 (/IDA) Q94JX9 (/IDA) Q94JX9 (/IDA) Q9LHG9 (/IDA) Q9LHG9 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
3 Q6ICZ8 (/IDA) Q9LHG9 (/IDA) Q9LHG9 (/IDA)
Cytosolic ribosome GO:0022626
A ribosome located in the cytosol.
3 Q6ICZ8 (/IDA) Q9LHG9 (/IDA) Q9LHG9 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q2HYP8 (/ISS) Q5E9A1 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 O97212 (/ISO) Q9U111 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q2HYP8 (/ISS) Q5E9A1 (/ISS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q5ANP2 (/IDA) Q5ANP2 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q6ICZ8 (/IDA)
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