The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Laminin
".
FunFam 206: Slit guidance ligand 3
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Roundabout binding GO:0048495
Interacting selectively and non-covalently with the Roundabout (ROBO) receptor, a transmembrane receptor.
|
2 | Q90Z43 (/ISA) Q90Z44 (/ISA) |
GTPase inhibitor activity GO:0005095
Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate.
|
1 | Q90Z44 (/ISA) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q9DE36 (/IPI) |
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
1 | Q90Z44 (/ISA) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q90Z44 (/ISA) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q90Z44 (/ISA) |
Laminin-1 binding GO:0043237
Interacting selectively and non-covalently with laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1.
|
1 | Q90Z44 (/ISA) |
Proteoglycan binding GO:0043394
Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
|
1 | Q90Z44 (/ISA) |
There are 53 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
|
5 | A0A0R4IFT2 (/IGI) A0A2R8Q7E7 (/IGI) A0A2R8RWP7 (/IGI) F1QQE4 (/IGI) Q9DE36 (/IGI) |
Central nervous system projection neuron axonogenesis GO:0021952
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.
|
5 | A0A0R4IFT2 (/IMP) A0A2R8Q7E7 (/IMP) A0A2R8RWP7 (/IMP) F1QQE4 (/IMP) Q9DE36 (/IMP) |
Negative regulation of axon extension GO:0030517
Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
|
5 | A0A0R4IFT2 (/IGI) A0A2R8Q7E7 (/IGI) A0A2R8RWP7 (/IGI) F1QQE4 (/IGI) Q9DE36 (/IGI) |
Negative regulation of axon extension GO:0030517
Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
|
5 | A0A0R4IFT2 (/IMP) A0A2R8Q7E7 (/IMP) A0A2R8RWP7 (/IMP) F1QQE4 (/IMP) Q9DE36 (/IMP) |
Morphogenesis of a branching structure GO:0001763
The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.
|
4 | A0A0R4IFT2 (/IMP) A0A2R8RWP7 (/IMP) F1QQE4 (/IMP) Q9DE36 (/IMP) |
Endocardial progenitor cell migration to the midline involved in heart field formation GO:0003262
The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart.
|
4 | A0A0R4IFT2 (/IGI) A0A2R8RWP7 (/IGI) F1QQE4 (/IGI) Q9DE36 (/IGI) |
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
4 | A0A0R4IFT2 (/IMP) A0A2R8RWP7 (/IMP) F1QQE4 (/IMP) Q9DE36 (/IMP) |
Axonal defasciculation GO:0007414
Separation of axons away from a bundle of axons known as a fascicle.
|
4 | A0A0R4IFT2 (/IMP) A0A2R8RWP7 (/IMP) F1QQE4 (/IMP) Q9DE36 (/IMP) |
Anterior/posterior axon guidance GO:0033564
The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
4 | A0A0R4IFT2 (/IMP) A0A2R8RWP7 (/IMP) F1QQE4 (/IMP) Q9DE36 (/IMP) |
Limb development GO:0060173
The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.
|
4 | Q90XG2 (/IEP) Q90XG4 (/IEP) Q90Z43 (/IEP) Q90Z44 (/IEP) |
Eye development GO:0001654
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
|
2 | Q90XG2 (/IEP) Q90XG4 (/IEP) |
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
2 | Q90Z43 (/IEP) Q90Z44 (/IEP) |
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
2 | Q90Z43 (/ISA) Q90Z44 (/ISA) |
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
|
2 | Q90Z43 (/ISA) Q90Z44 (/ISA) |
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
2 | Q90Z43 (/ISA) Q90Z44 (/ISA) |
Roundabout signaling pathway GO:0035385
A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q90Z43 (/ISA) Q90Z44 (/ISA) |
Inner ear development GO:0048839
The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.
|
2 | Q90Z43 (/IEP) Q90Z44 (/IEP) |
Axon extension involved in axon guidance GO:0048846
The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues.
|
2 | Q90Z43 (/ISA) Q90Z44 (/ISA) |
Negative chemotaxis GO:0050919
The directed movement of a motile cell or organism towards a lower concentration of a chemical.
|
2 | Q90Z43 (/ISA) Q90Z44 (/ISA) |
Response to cortisol GO:0051414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions.
|
2 | Q90Z43 (/ISA) Q90Z44 (/ISA) |
Apoptotic process involved in luteolysis GO:0061364
The apoptotic process that contributes to luteolysis.
|
2 | Q90Z43 (/ISA) Q90Z44 (/ISA) |
Negative regulation of chemokine-mediated signaling pathway GO:0070100
Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor.
|
2 | Q90Z43 (/ISA) Q90Z44 (/ISA) |
Ossification GO:0001503
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
|
1 | Q90XG4 (/IEP) |
Ureteric bud development GO:0001657
The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.
|
1 | Q90Z44 (/ISA) |
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
|
1 | Q90Z44 (/ISA) |
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
|
1 | Q90Z44 (/ISA) |
Negative regulation of leukocyte chemotaxis GO:0002689
Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.
|
1 | Q90Z44 (/ISA) |
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
1 | Q90XG2 (/IEP) |
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q90Z44 (/ISA) |
Negative regulation of lamellipodium assembly GO:0010593
Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
|
1 | Q90Z44 (/ISA) |
Negative regulation of endothelial cell migration GO:0010596
Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
|
1 | Q90Z44 (/ISA) |
Negative regulation of smooth muscle cell migration GO:0014912
Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.
|
1 | Q90Z44 (/ISA) |
Chemorepulsion involved in postnatal olfactory bulb interneuron migration GO:0021836
The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration.
|
1 | Q90Z44 (/ISA) |
Neural tube development GO:0021915
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
|
1 | Q90XG2 (/IEP) |
Corticospinal neuron axon guidance through spinal cord GO:0021972
The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues.
|
1 | Q90Z44 (/ISA) |
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
|
1 | Q90Z44 (/ISA) |
Negative regulation of actin filament polymerization GO:0030837
Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
|
1 | Q90Z44 (/ISA) |
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
|
1 | Q90Z44 (/ISA) |
Negative regulation of GTPase activity GO:0034260
Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
|
1 | Q90Z44 (/ISA) |
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q90Z44 (/ISA) |
Negative regulation of catalytic activity GO:0043086
Any process that stops or reduces the activity of an enzyme.
|
1 | Q90Z44 (/ISA) |
Negative regulation of vascular permeability GO:0043116
Any process that reduces the extent to which blood vessels can be pervaded by fluid.
|
1 | Q90Z44 (/ISA) |
Branching morphogenesis of an epithelial tube GO:0048754
The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.
|
1 | Q90Z44 (/ISA) |
Induction of negative chemotaxis GO:0050929
Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical.
|
1 | Q90Z44 (/ISA) |
Negative regulation of small GTPase mediated signal transduction GO:0051058
Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction.
|
1 | Q90Z44 (/ISA) |
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
|
1 | Q90XG4 (/IEP) |
Myoblast migration GO:0051451
The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
1 | Q90Z44 (/IEP) |
Cellular response to heparin GO:0071504
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus.
|
1 | Q90Z44 (/ISA) |
Negative regulation of smooth muscle cell chemotaxis GO:0071672
Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis.
|
1 | Q90Z44 (/ISA) |
Negative regulation of mononuclear cell migration GO:0071676
Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.
|
1 | Q90Z44 (/ISA) |
Negative regulation of neutrophil chemotaxis GO:0090024
Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
|
1 | Q90Z44 (/ISA) |
Negative regulation of retinal ganglion cell axon guidance GO:0090260
Any process that decreases the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
|
1 | Q90Z44 (/ISA) |
Negative regulation of cellular response to growth factor stimulus GO:0090288
Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
|
1 | Q90Z44 (/ISA) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
3 | Q90XG4 (/IDA) Q90Z43 (/IDA) Q90Z44 (/IDA) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | Q90Z43 (/ISA) Q90Z44 (/ISA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q90Z44 (/ISA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q90Z44 (/ISA) |