The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Laminin
".
FunFam 158: proheparin-binding EGF-like growth factor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
|
4 | P31955 (/ISO) P31955 (/ISO) Q06186 (/ISO) Q06186 (/ISO) |
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
|
4 | P24338 (/IDA) Q06186 (/IDA) Q06186 (/IDA) Q99075 (/IDA) |
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
|
4 | P31955 (/ISO) P31955 (/ISO) Q06186 (/ISO) Q06186 (/ISO) |
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
|
3 | P24338 (/IDA) Q06186 (/IDA) Q06186 (/IDA) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P15514 (/IPI) Q9W7C5 (/IPI) |
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
2 | Q06186 (/IDA) Q06186 (/IDA) |
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
2 | Q06186 (/ISO) Q06186 (/ISO) |
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
|
1 | Q06175 (/IMP) |
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
|
1 | Q99075 (/TAS) |
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
|
1 | Q06175 (/IMP) |
Showing 1 to 10 of 12 entries
There are 68 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
5 | P24338 (/IDA) P31955 (/IDA) P31955 (/IDA) Q06186 (/IDA) Q06186 (/IDA) |
Heart contraction GO:0060047
The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.
|
5 | A0A2R8RUB3 (/IMP) A7E275 (/IMP) F1QEL2 (/IMP) F1QKE6 (/IMP) Q6NY79 (/IMP) |
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
4 | P15514 (/IDA) P24338 (/IDA) Q06186 (/IDA) Q06186 (/IDA) |
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
4 | P31955 (/ISO) P31955 (/ISO) Q06186 (/ISO) Q06186 (/ISO) |
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
4 | P31955 (/IDA) P31955 (/IDA) Q06186 (/IDA) Q06186 (/IDA) |
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
3 | P15514 (/TAS) Q06175 (/TAS) Q99075 (/TAS) |
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
|
2 | P15514 (/TAS) Q99075 (/TAS) |
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
2 | Q06186 (/NAS) Q06186 (/NAS) |
Blastocyst growth GO:0001832
An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.
|
2 | Q06186 (/TAS) Q06186 (/TAS) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
2 | P15514 (/TAS) Q99075 (/TAS) |
Showing 1 to 10 of 68 entries
There are 20 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
5 | P15514 (/IDA) P24338 (/IDA) Q06186 (/IDA) Q06186 (/IDA) Q99075 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
4 | P15514 (/TAS) Q06186 (/TAS) Q06186 (/TAS) Q99075 (/TAS) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
4 | P31955 (/ISO) P31955 (/ISO) Q06186 (/ISO) Q06186 (/ISO) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
4 | P31955 (/ISO) P31955 (/ISO) Q06186 (/ISO) Q06186 (/ISO) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | P15514 (/TAS) Q99075 (/TAS) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P31955 (/IDA) P31955 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P31955 (/IDA) P31955 (/IDA) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | Q06186 (/IDA) Q06186 (/IDA) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | P15514 (/IDA) Q99075 (/IDA) |
Clathrin-coated vesicle membrane GO:0030665
The lipid bilayer surrounding a clathrin-coated vesicle.
|
2 | P15514 (/TAS) Q99075 (/TAS) |
Showing 1 to 10 of 20 entries