The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Dbl homology (DH) domain
".
FunFam 8: rho guanine nucleotide exchange factor 25
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 14 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
8 | C4ALD5 (/IDA) H2KYM2 (/IDA) H2KYM3 (/IDA) H2KYM4 (/IDA) O61528 (/IDA) Q7JNG4 (/IDA) Q7JNG6 (/IDA) Q95Q51 (/IDA) |
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
|
8 | C4ALD5 (/IPI) H2KYM2 (/IPI) H2KYM3 (/IPI) H2KYM4 (/IPI) O61528 (/IPI) Q7JNG4 (/IPI) Q7JNG6 (/IPI) Q95Q51 (/IPI) |
Rac guanyl-nucleotide exchange factor activity GO:0030676
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
8 | C4ALD5 (/IDA) H2KYM2 (/IDA) H2KYM3 (/IDA) H2KYM4 (/IDA) O61528 (/IDA) Q7JNG4 (/IDA) Q7JNG6 (/IDA) Q95Q51 (/IDA) |
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
|
8 | C4ALD5 (/IPI) H2KYM2 (/IPI) H2KYM3 (/IPI) H2KYM4 (/IPI) O61528 (/IPI) Q7JNG4 (/IPI) Q7JNG6 (/IPI) Q95Q51 (/IPI) |
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
5 | O60229 (/TAS) O75962 (/TAS) P97924 (/TAS) P97924 (/TAS) Q2L4X0 (/TAS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | O75962 (/IPI) P97924 (/IPI) P97924 (/IPI) Q2L4X0 (/IPI) Q9CWR0 (/IPI) |
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
3 | F1M0Z1 (/IPI) P97924 (/IPI) P97924 (/IPI) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
2 | O60229 (/TAS) O75962 (/TAS) |
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
2 | A2CG49 (/ISO) Q0KL02 (/ISO) |
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | O60229 (/EXP) |
Showing 1 to 10 of 14 entries
There are 69 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
8 | C4ALD5 (/IMP) H2KYM2 (/IMP) H2KYM3 (/IMP) H2KYM4 (/IMP) O61528 (/IMP) Q7JNG4 (/IMP) Q7JNG6 (/IMP) Q95Q51 (/IMP) |
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
8 | C4ALD5 (/TAS) H2KYM2 (/TAS) H2KYM3 (/TAS) H2KYM4 (/TAS) O61528 (/TAS) Q7JNG4 (/TAS) Q7JNG6 (/TAS) Q95Q51 (/TAS) |
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
|
8 | C4ALD5 (/NAS) H2KYM2 (/NAS) H2KYM3 (/NAS) H2KYM4 (/NAS) O61528 (/NAS) Q7JNG4 (/NAS) Q7JNG6 (/NAS) Q95Q51 (/NAS) |
Mesodermal cell migration GO:0008078
The orderly movement of mesodermal cells from one site to another.
|
8 | C4ALD5 (/TAS) H2KYM2 (/TAS) H2KYM3 (/TAS) H2KYM4 (/TAS) O61528 (/TAS) Q7JNG4 (/TAS) Q7JNG6 (/TAS) Q95Q51 (/TAS) |
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
|
8 | C4ALD5 (/NAS) H2KYM2 (/NAS) H2KYM3 (/NAS) H2KYM4 (/NAS) O61528 (/NAS) Q7JNG4 (/NAS) Q7JNG6 (/NAS) Q95Q51 (/NAS) |
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
8 | C4ALD5 (/TAS) H2KYM2 (/TAS) H2KYM3 (/TAS) H2KYM4 (/TAS) O61528 (/TAS) Q7JNG4 (/TAS) Q7JNG6 (/TAS) Q95Q51 (/TAS) |
Rac protein signal transduction GO:0016601
A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.
|
8 | C4ALD5 (/IC) H2KYM2 (/IC) H2KYM3 (/IC) H2KYM4 (/IC) O61528 (/IC) Q7JNG4 (/IC) Q7JNG6 (/IC) Q95Q51 (/IC) |
Oviposition GO:0018991
The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water.
|
8 | C4ALD5 (/TAS) H2KYM2 (/TAS) H2KYM3 (/TAS) H2KYM4 (/TAS) O61528 (/TAS) Q7JNG4 (/TAS) Q7JNG6 (/TAS) Q95Q51 (/TAS) |
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
|
8 | A0A0R4IJ99 (/IMP) A0A0R4IVJ3 (/IMP) A0A0R4IYK1 (/IMP) A0A2R8Q841 (/IMP) A0A2R8RHL8 (/IMP) A0A2R8RYT7 (/IMP) A9JSZ2 (/IMP) Q1RLV0 (/IMP) |
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
|
8 | C4ALD5 (/IDA) H2KYM2 (/IDA) H2KYM3 (/IDA) H2KYM4 (/IDA) O61528 (/IDA) Q7JNG4 (/IDA) Q7JNG6 (/IDA) Q95Q51 (/IDA) |
Showing 1 to 10 of 69 entries
There are 29 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
8 | C4ALD5 (/IDA) H2KYM2 (/IDA) H2KYM3 (/IDA) H2KYM4 (/IDA) O61528 (/IDA) Q7JNG4 (/IDA) Q7JNG6 (/IDA) Q95Q51 (/IDA) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
8 | C4ALD5 (/IDA) H2KYM2 (/IDA) H2KYM3 (/IDA) H2KYM4 (/IDA) O61528 (/IDA) Q7JNG4 (/IDA) Q7JNG6 (/IDA) Q95Q51 (/IDA) |
Muscle cell projection GO:0036194
A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.
|
8 | C4ALD5 (/IDA) H2KYM2 (/IDA) H2KYM3 (/IDA) H2KYM4 (/IDA) O61528 (/IDA) Q7JNG4 (/IDA) Q7JNG6 (/IDA) Q95Q51 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | O60229 (/TAS) O75962 (/TAS) Q86VW2 (/TAS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | H7BXZ5 (/IDA) O60229 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | H7BXZ5 (/IDA) O60229 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q6P720 (/ISS) Q86VW2 (/ISS) |
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
2 | P97924 (/IDA) P97924 (/IDA) |
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
|
2 | P97924 (/IMP) P97924 (/IMP) |
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
|
2 | Q6P720 (/ISS) Q86VW2 (/ISS) |
Showing 1 to 10 of 29 entries