CATH Superfamily 1.20.900.10

Browse Functional Families

ID	Function Family (FunFam) Name	Total Sequences	Structure?	Structural Representative	PDB Sites?	Alignment Diversity (0-100)
1	Guanine nucleotide exchange factor DBS	885	3D	2nz8B01	-	80.1
2	Rho guanine nucleotide exchange factor 9	823	3D	2pz1A02	-	74.7
3	Rho guanine nucleotide exchange factor 10 like	655		-	-	92.0
4	Rho guanine nucleotide exchange factor 2	601	3D	4d0oB00	-	90.8
6	Rho guanine nucleotide exchange factor GEF	544	3D	5jhhE01	-	89.1
5	Ras-specific guanine nucleotide-releasing factor 1 isoform 2	543		-	-	48.2
7	rho guanine nucleotide exchange factor 19	507		-	-	93.1
8	rho guanine nucleotide exchange factor 25	454	3D	2rgnE01	-	89.2
9	Vav guanine nucleotide exchange factor 1	409	3D	2vrwB01	-	80.4
10	Rho guanine nucleotide exchange factor 3 isoform 1	358	3D	2z0qA01	-	60.9
11	Intersectin 1	307	3D	5hziB01	-	73.4
12	T cell lymphoma invasion and metastasis 1	301	3D	1foeG01	-	64.9
13	FYVE, RhoGEF and PH domain-containing protein 4	288		-	-	73.2
14	active breakpoint cluster region-related protein isoform X2	254		-	-	59.0
15	son of sevenless homolog 1 isoform X1	245	3D	3ksyA02	-	82.3
16	Rho guanine nucleotide exchange factor 6	242	3D	1by1A00	-	81.2
18	Phosphatidylinositol-3,4, 5-trisphosphate-dependent Rac exchange factor 2, putative	221	3D	5fi1A01	-	76.4
17	pleckstrin homology domain-containing family G member 5 isoform X1	217		-	-	74.4
19	Pleckstrin homology domain-containing family G member 1	203		-	-	81.3
20	FERM, RhoGEF and pleckstrin domain-containing protein 2	198	3D	4gzuB01	-	65.9
21	FERM, RhoGEF and pleckstrin domain-containing protein 1	174		-	-	88.0
22	protein ECT2 isoform X1	172		-	-	63.8
23	dynamin-binding protein isoform X2	161		-	-	77.2
24	FYVE, RhoGEF and PH domain-containing protein 6	143	3D	3mpxA01	-	75.1
25	Rho guanine nucleotide exchange factor 17	92		-	-	68.6
26	Alsin isoform X1	80		-	-	48.1
27	Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	77		-	-	71.9
28	Puratrophin-1-like, isoform D	61		-	-	59.9
29	Rho guanine nucleotide exchange factor 37	57		-	-	74.4
30	rho guanine nucleotide exchange factor 39	55		-	-	54.5
31	Uncharacterized protein, isoform B	46		-	-	21.3
32	rho guanine nucleotide exchange factor 38	41		-	-	71.1
33	Muscle M-line assembly protein unc-89-like Protein	37		-	-	71.1
34	Uncharacterized protein, isoform B	35		-	-	13.8
35	Rho guanyl nucleotide exchange factor	32		-	-	79.0
36	EG:23E12.2, isoform B	32		-	-	37.4
37	Protostome-specific GEF, isoform C	31		-	-	19.2
38	Myosin-M heavy chain	28		-	-	91.7
39	Uncharacterized protein, isoform C	27		-	-	4.5
40	Trio, isoform D	27		-	-	16.3
42	uncharacterized protein LOC108093793 isoform X3	24		-	-	12.8
41	Rho guanyl nucleotide exchange factor	24		-	-	64.2
43	ALS2 C-terminal like	22		-	-	38.0
44	Uncharacterized protein, isoform B	21		-	-	16.2
46	Related to CDC24-GTP/GDP exchange factor for Cdc42p	20		-	-	73.4
45	Uncharacterized protein, isoform C	20		-	-	55.6
48	GL21162	17		-	-	24.4
49	Rho guanine nucleotide exchange factor 38	17		-	-	29.0
47	Uncharacterized protein, isoform A	17		-	-	17.5
50	Guanine nucleotide exchange factor	16		-	-	57.4
51	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1	15		-	-	36.4
53	Rho guanyl nucleotide exchange factor, putative	13		-	-	76.6
52	Cell division control protein 24	13		-	-	13.5
54	CDC-42 Guanine nucleotide Exchange Factor	13		-	-	17.5
55	UNC-112-Interacting Guanine nucleotide exchange factor	12		-	-	8.3
57	Rho guanine nucleotide exchange factor 38	11		-	-	20.7
56	TOR unique function suppressor	11		-	-	10.0
58	Uncharacterized protein, isoform A	9		-	-	4.7
59	Protein CBG22463	9		-	-	19.5
60	Rho guanine nucleotide exchange factor osg-1	9		-	-	30.8
61	TIAM Mammalian Tumor Invasion And Metastasis factor	8		-	-	7.6
62	Unplaced genomic scaffold supercont1.14, whole genome shotgun sequence	8		-	-	14.1
63	Rho guanine nucleotide exchange factor GEF	8		-	-	91.1
66	RhoGAP domain containing protein	7		-	-	10.9
64	Muscle M-line assembly protein unc-89	7		-	-	3.3
65	T-cell activation Rho GTPase activating protein, putative	7		-	-	3.9
68	FUS2p Cell fusion regulator	6		-	-	1.4
69	Uncharacterized protein	6		-	-	0.0
67	Rho guanyl nucleotide exchange factor, putative AFU_orthologue AFUA_5G11890	6		-	-	19.9
70	FERM domain Protein4.1-ezrin-radixin-moesin	5		-	-	15.1
71	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform a	4		-	-	39.7
72	Putative Rho guanine nucleotide exchange factor FGD-1	4		-	-	0.0
73	Putative RhoGEF group protein	4		-	-	5.7
76	Uncharacterized protein	3		-	-	20.7
78	Guanine nucleotide exchange factor UNC-73B	3		-	-	0.0
74	RHo Guanine nucleotide exchange Factor	3		-	-	0.0
80	FERM, ARHGEF and pleckstrin domain-containing protein 1	3		-	-	2.6
77	Uncharacterized protein	3		-	-	0.0
79	Obscurin	3		-	-	14.0
75	Rho guanine nucleotide exchange factor 38	3		-	-	12.8
96	Uncharacterized protein	2		-	-	39.4
87	FERM, ARH/RhoGEF and pleckstrin domain protein 2	2		-	-	6.8
85	Uncharacterized protein	2		-	-	43.2
89	PIX PAK (p21-activated kinase	2		-	-	0.0
91	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2	2		-	-	4.9
92	Son of sevenless homolog	2		-	-	0.0
84	Kalirin RhoGEF kinase a	2		-	-	43.8
94	Dynamin-binding protein	2		-	-	0.0
82	Uncharacterized protein	2		-	-	0.0
90	YALI0F13673p	2		-	-	0.0
93	ECT2 Mammalian Rho GEF	2		-	-	0.0
83	Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF a	2		-	-	6.4
95	Rho GTPase-activating protein 20	2		-	-	0.0
81	Protein ECT2	2		-	-	43.5
86	Uncharacterized protein	2		-	-	19.1
88	Putative rho guanine nucleotide exchange factor cdep	2		-	-	10.0
127	Uncharacterized protein	1		-	-	0.0
101	Rho guanine nucleotide exchange factor GEF	1		-	-	0.0
98	AT26020p	1		-	-	0.0
119	Uncharacterized protein	1		-	-	0.0
107	Predicted protein	1		-	-	0.0
136	Predicted protein	1		-	-	0.0
116	Rho guanine nucleotide exchange factor gef2	1		-	-	0.0
110	GH01987p	1		-	-	0.0
112	RH56938p	1		-	-	0.0
108	Uncharacterized protein	1		-	-	0.0
128	Son of sevenless 1	1		-	-	0.0
130	Rho GTPase regulating protein, putative	1		-	-	0.0
102	MKIAA0380 protein	1		-	-	0.0
115	Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	1		-	-	0.0
122	Uncharacterized protein	1		-	-	0.0
132	Predicted protein	1		-	-	0.0
125	Uncharacterized protein	1		-	-	0.0
117	Rac guanine nucleotide exchange factor B	1		-	-	0.0
105	Uncharacterized protein	1		-	-	0.0
111	Protein CBG05206	1		-	-	0.0
118	Uncharacterized protein	1		-	-	0.0
129	Predicted protein	1		-	-	0.0
135	Predicted protein	1		-	-	0.0
124	Uncharacterized protein	1		-	-	0.0
113	Chromosome 7, whole genome shotgun sequence	1		-	-	0.0
100	Uncharacterized protein	1		-	-	0.0
120	Rho guanine nucleotide exchange factor 37	1		-	-	0.0
109	Uncharacterized protein	1		-	-	0.0
126	Kalirin RhoGEF kinase a	1		-	-	0.0
99	Rho1 guanine nucleotide exchange factor 3	1		-	-	0.0
114	Uncharacterized protein	1		-	-	0.0
104	Uncharacterized protein	1		-	-	0.0
131	Uncharacterized protein	1		-	-	0.0
103	Meiotically up-regulated gene 10 protein	1		-	-	0.0
97	MKIAA1209 protein	1		-	-	0.0
106	Uncharacterized protein	1		-	-	0.0
121	Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b	1		-	-	0.0
133	Probable serine/threonine-protein kinase roco5	1		-	-	0.0
123	Uncharacterized protein	1		-	-	0.0
134	BAR domaincontaining protein	1		-	-	0.0