The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Cytochrome P450
".
FunFam 31: cholesterol 24-hydroxylase isoform X2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cholesterol 24-hydroxylase activity GO:0033781
Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+).
|
5 | Q9WVK8 (/IDA) Q9WVK8 (/IDA) Q9Y6A2 (/IDA) Q9Y6A2 (/IDA) Q9Y6A2 (/IDA) |
|
Steroid hydroxylase activity GO:0008395
Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.
|
3 | Q9Y6A2 (/IDA) Q9Y6A2 (/IDA) Q9Y6A2 (/IDA) |
|
Steroid hydroxylase activity GO:0008395
Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.
|
3 | Q9Y6A2 (/TAS) Q9Y6A2 (/TAS) Q9Y6A2 (/TAS) |
|
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
|
3 | Q9Y6A2 (/IDA) Q9Y6A2 (/IDA) Q9Y6A2 (/IDA) |
|
Cholesterol 24-hydroxylase activity GO:0033781
Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+).
|
3 | Q9Y6A2 (/TAS) Q9Y6A2 (/TAS) Q9Y6A2 (/TAS) |
|
Steroid hydroxylase activity GO:0008395
Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.
|
2 | Q9WVK8 (/ISO) Q9WVK8 (/ISO) |
|
Steroid hydroxylase activity GO:0008395
Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.
|
2 | Q9WVK8 (/ISS) Q9WVK8 (/ISS) |
|
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
|
2 | Q9WVK8 (/ISO) Q9WVK8 (/ISO) |
|
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
|
2 | Q9WVK8 (/ISS) Q9WVK8 (/ISS) |
|
Cholesterol 24-hydroxylase activity GO:0033781
Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+).
|
2 | Q9WVK8 (/ISO) Q9WVK8 (/ISO) |
|
Cholesterol 24-hydroxylase activity GO:0033781
Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+).
|
2 | Q9WVK8 (/ISS) Q9WVK8 (/ISS) |
There are 15 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cholesterol catabolic process GO:0006707
The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
5 | Q9WVK8 (/IDA) Q9WVK8 (/IDA) Q9Y6A2 (/IDA) Q9Y6A2 (/IDA) Q9Y6A2 (/IDA) |
|
Bile acid biosynthetic process GO:0006699
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
|
3 | Q9Y6A2 (/TAS) Q9Y6A2 (/TAS) Q9Y6A2 (/TAS) |
|
Cholesterol catabolic process GO:0006707
The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
3 | Q9Y6A2 (/TAS) Q9Y6A2 (/TAS) Q9Y6A2 (/TAS) |
|
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
|
3 | Q9Y6A2 (/IDA) Q9Y6A2 (/IDA) Q9Y6A2 (/IDA) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
3 | Q9Y6A2 (/TAS) Q9Y6A2 (/TAS) Q9Y6A2 (/TAS) |
|
Sterol metabolic process GO:0016125
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
|
3 | Q9Y6A2 (/TAS) Q9Y6A2 (/TAS) Q9Y6A2 (/TAS) |
|
Progesterone metabolic process GO:0042448
The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants.
|
3 | Q9Y6A2 (/IDA) Q9Y6A2 (/IDA) Q9Y6A2 (/IDA) |
|
Regulation of long-term synaptic potentiation GO:1900271
Any process that modulates the frequency, rate or extent of long-term synaptic potentiation.
|
3 | Q9Y6A2 (/ISS) Q9Y6A2 (/ISS) Q9Y6A2 (/ISS) |
|
Cholesterol catabolic process GO:0006707
The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
2 | Q9WVK8 (/ISO) Q9WVK8 (/ISO) |
|
Cholesterol catabolic process GO:0006707
The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
2 | Q9WVK8 (/ISS) Q9WVK8 (/ISS) |
|
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
|
2 | Q9WVK8 (/ISO) Q9WVK8 (/ISO) |
|
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
|
2 | Q9WVK8 (/ISS) Q9WVK8 (/ISS) |
|
Progesterone metabolic process GO:0042448
The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants.
|
2 | Q9WVK8 (/ISO) Q9WVK8 (/ISO) |
|
Progesterone metabolic process GO:0042448
The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants.
|
2 | Q9WVK8 (/ISS) Q9WVK8 (/ISS) |
|
Regulation of long-term synaptic potentiation GO:1900271
Any process that modulates the frequency, rate or extent of long-term synaptic potentiation.
|
2 | Q9WVK8 (/IMP) Q9WVK8 (/IMP) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
3 | Q9Y6A2 (/TAS) Q9Y6A2 (/TAS) Q9Y6A2 (/TAS) |
|
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
3 | Q9Y6A2 (/TAS) Q9Y6A2 (/TAS) Q9Y6A2 (/TAS) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
3 | Q9Y6A2 (/ISS) Q9Y6A2 (/ISS) Q9Y6A2 (/ISS) |
|
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
|
3 | Q9Y6A2 (/ISS) Q9Y6A2 (/ISS) Q9Y6A2 (/ISS) |
|
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
|
3 | Q9Y6A2 (/ISS) Q9Y6A2 (/ISS) Q9Y6A2 (/ISS) |
|
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
2 | Q9WVK8 (/IDA) Q9WVK8 (/IDA) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
2 | Q9WVK8 (/IDA) Q9WVK8 (/IDA) |
|
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
|
2 | Q9WVK8 (/IDA) Q9WVK8 (/IDA) |
|
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
|
2 | Q9WVK8 (/IDA) Q9WVK8 (/IDA) |
