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CATH Superfamily 1.10.630.10

Cytochrome P450

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cytochrome P450
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 31: cholesterol 24-hydroxylase isoform X2

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cholesterol 24-hydroxylase. [EC: 1.14.14.25]
Cholesterol + [reduced NADPH--hemoprotein reductase] + O(2) = (24S)- cholest-5-ene-3-beta,24-diol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
  • The enzyme can also produce 25-hydroxycholesterol.
  • In addition, it can further hydroxylate the product to 24,25- dihydroxycholesterol and 24,27-dihydroxycholesterol.
  • This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood- brain barrier whereas cholesterol cannot.
  • The direct electron donor to the enzyme is EC 1.6.2.4.
  • Formerly EC 1.14.13.98.
 13 A0A2J8TL67 A0A2J8TL67 A0A2J8TL67 H2Q8X0 H2Q8X0 H2Q8X0 Q3US73 Q3US73 Q9WVK8 Q9WVK8
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