CATH Domain 5hw4C02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.950	Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2
	3.30.950.10	Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2

Domain Context

CATH Clusters

Superfamily	Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2
Functional Family	Ribosomal RNA small subunit methyltransferase I

Enzyme Information

2.1.1.198

16S rRNA (cytidine(1402)-2'-O)-methyltransferase.

based on mapping to UniProt P67087

S-adenosyl-L-methionine + cytidine(1402) in 16S rRNA = S-adenosyl-L- homocysteine + 2'-O-methylcytidine(1402) in 16S rRNA.

-!- RsmI catalyzes the 2'-O-methylation of cytidine(1402) and RsmH (EC 2.1.1.199) catalyzes the N(4)-methylation of cytidine(1402) in 16S rRNA. -!- Both methylations are necessary for efficient translation initiation at the UUG and GUG codons.

UniProtKB Entries (1)

P67087

RSMI_ECOLI

Escherichia coli K-12

Ribosomal RNA small subunit methyltransferase I

PDB Structure

PDB	5HW4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Insights into the Methylation of C1402 in 16S rRNA by Methyltransferase RsmI Zhao, M., Zhang, H., Liu, G., Wang, L., Wang, J., Gao, Z., Dong, Y., Zhang, L., Gong, Y. Plos One