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CATH Superfamily 3.30.950.10

Tetrapyrrole methylase, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Tetrapyrrole methylase, C-terminal domain

This superfamily entry represents the C-terminal subdomain from several tetrapyrrole methylases. Tetrapyrroles are large macrocyclic compounds derived from a common biosynthetic pathway PMID:11215515. Tetrapyrrole methylases catalyse the methylation of cyclic tetrapyrrole rings using methyl groups derived from S-adenosylmethionine (SAM) for the biosynthesis of modified tetrapyrroles such as cobalamin (vitamin B12), haem, sirohaem, chlorophyll, coenzyme F430 and phytochromobilin PMID:17227226. Enzymes in this superfamily include: S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase (SUMT) PMID:15522295, precorrin-2 C20-methyltransferase CobI/CbiL PMID:17229157, precorrin-4 C11-methyltransferase CobM/CbiF PMID:16866557, sirohaem synthase CysG PMID:14595395 and diphthine synthase PMID:18391406.

INTERPRO:IPR014776, PFAM:PF00590

GO Diversity

Unique GO annotations
30 Unique GO terms

EC Diversity

Unique EC annotations
17 Unique EC terms

Species Diversity

Unique species annotations
17553 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 228
Domain clusters (>95% seq id): 24
Domain clusters (>35% seq id): 15
Unique PDBs: 113
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 30
Function
Unique EC: 17
Unique GO: 30
Taxonomy
Unique Species: 17553
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