CATH Domain 4yauA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.360	Flavodoxin domain

Domain Context

CATH Clusters

Superfamily	3.40.50.360
Functional Family	NADPH--cytochrome P450 reductase

Enzyme Information

1.6.2.4

NADPH--hemoprotein reductase.

based on mapping to UniProt P00388

NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.

-!- This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. -!- It also reduces cytochrome b5 and cytochrome c. -!- The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.

UniProtKB Entries (1)

P00388

NCPR_RAT

Rattus norvegicus

NADPH--cytochrome P450 reductase

PDB Structure

PDB	4YAU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone. Rwere, F., Xia, C., Im, S., Haque, M.M., Stuehr, D.J., Waskell, L., Kim, J.J. J.Biol.Chem.