CATH Domain 2z9cA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.360	Flavodoxin domain

Domain Context

CATH Clusters

Superfamily	3.40.50.360
Functional Family	FMN-dependent NADH-azoreductase

Enzyme Information

1.7.1.17

FMN-dependent NADH-azoreductase.

based on mapping to UniProt P41407

Anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 NADH.

-!- The enzyme catalyzes the reductive cleavage of an azo bond in aromatic azo compounds to form the corresponding amines. -!- Does not accept NADPH. -!- Cf. EC 1.7.1.6.

UniProtKB Entries (1)

P41407

AZOR_ECOLI

Escherichia coli K-12

FMN-dependent NADH-azoreductase

PDB Structure

PDB	2Z9C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Expansion of Substrate Specificity and Catalytic Mechanism of Azoreductase by X-ray Crystallography and Site-directed Mutagenesis Ito, K., Nakanishi, M., Lee, W.C., Zhi, Y., Sasaki, H., Zenno, S., Saigo, K., Kitade, Y., Tanokura, M. J.Biol.Chem.