The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Helix-loop-helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: Transcription factor HES-1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 58 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
31 P35428 (/ISS) P35428 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(21 more)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
29 Q04666 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(19 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
29 Q04666 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(19 more)
N-box binding GO:0071820
Interacting selectively and non-covalently with an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses.
29 Q04666 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(19 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
28 P14003 (/IPI) P35428 (/IPI) P35428 (/IPI) Q01068 (/IPI) Q01068 (/IPI) Q01071 (/IPI) Q01071 (/IPI) Q01071 (/IPI) Q04666 (/IPI) Q14469 (/IPI)
(18 more)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
22 O54792 (/NAS) P35428 (/NAS) P35428 (/NAS) Q14469 (/NAS) Q14469 (/NAS) Q14469 (/NAS) Q14469 (/NAS) Q14469 (/NAS) Q14469 (/NAS) Q14469 (/NAS)
(12 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
19 Q14469 (/ISM) Q14469 (/ISM) Q14469 (/ISM) Q14469 (/ISM) Q14469 (/ISM) Q14469 (/ISM) Q14469 (/ISM) Q14469 (/ISM) Q14469 (/ISM) Q14469 (/ISM)
(9 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
18 Q14469 (/NAS) Q14469 (/NAS) Q14469 (/NAS) Q14469 (/NAS) Q14469 (/NAS) Q14469 (/NAS) Q14469 (/NAS) Q14469 (/NAS) Q14469 (/NAS) Q14469 (/NAS)
(8 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
15 Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS)
(5 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
15 Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA)
(5 more)
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
15 Q14469 (/IPI) Q14469 (/IPI) Q14469 (/IPI) Q14469 (/IPI) Q14469 (/IPI) Q14469 (/IPI) Q14469 (/IPI) Q14469 (/IPI) Q14469 (/IPI) Q14469 (/IPI)
(5 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
14 P13097 (/IDA) Q01068 (/IDA) Q01068 (/IDA) Q01069 (/IDA) Q01070 (/IDA) Q01070 (/IDA) Q01071 (/IDA) Q01071 (/IDA) Q01071 (/IDA) Q04666 (/IDA)
(4 more)
Sequence-specific double-stranded DNA binding GO:1990837
Interacting selectively and non-covalently with double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
10 P13097 (/IDA) Q01068 (/IDA) Q01068 (/IDA) Q01069 (/IDA) Q01070 (/IDA) Q01070 (/IDA) Q01071 (/IDA) Q01071 (/IDA) Q01071 (/IDA) Q26263 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
6 P13097 (/IDA) P14003 (/IDA) P35428 (/IDA) P35428 (/IDA) P35429 (/IDA) Q26263 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
6 Q00P32 (/IPI) Q00P32 (/IPI) Q6IRB2 (/IPI) Q6IRB2 (/IPI) Q90VV1 (/IPI) Q90VV1 (/IPI)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
5 F1QI81 (/IDA) P35428 (/IDA) P35428 (/IDA) Q9DEU7 (/IDA) Q9DEU8 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
5 P14003 (/IDA) P35428 (/IDA) P35428 (/IDA) Q04666 (/IDA) Q26263 (/IDA)
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
5 Q00P32 (/IPI) Q00P32 (/IPI) Q6IRB2 (/IPI) Q6IRB2 (/IPI) Q90Z12 (/IPI)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 Q9HCC6 (/ISA) Q9Y543 (/ISA) Q9Y543 (/ISA) Q9Y543 (/ISA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
4 Q01069 (/IMP) Q01070 (/IMP) Q01070 (/IMP) Q26263 (/IMP)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 O57337 (/IDA) P35428 (/IDA) P35428 (/IDA) Q04666 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
4 Q5PPM5 (/ISS) Q6PBD4 (/ISS) Q8AVU4 (/ISS) Q8AVU4 (/ISS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
3 P13097 (/IGI) Q01070 (/IGI) Q01070 (/IGI)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
3 P13097 (/IPI) P14003 (/IPI) Q04666 (/IPI)
Enhancer binding GO:0035326
Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.
3 Q01070 (/IDA) Q01070 (/IDA) Q26263 (/IDA)
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
3 Q5PPM5 (/ISS) Q8AVU4 (/ISS) Q8AVU4 (/ISS)
N-box binding GO:0071820
Interacting selectively and non-covalently with an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses.
3 P35428 (/IDA) P35428 (/IDA) Q04666 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 P35428 (/ISO) P35428 (/ISO)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 P35428 (/ISO) P35428 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 P35428 (/ISO) P35428 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 P35428 (/ISS) P35428 (/ISS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
2 P35428 (/ISO) P35428 (/ISO)
JUN kinase binding GO:0008432
Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.
2 P35428 (/ISO) P35428 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q00P32 (/IPI) Q00P32 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P35428 (/ISO) P35428 (/ISO)
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
2 P35428 (/ISO) P35428 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 Q90VV1 (/IPI) Q90VV1 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 P35428 (/ISO) P35428 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 P35428 (/ISO) P35428 (/ISO)
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
2 P35428 (/IDA) P35428 (/IDA)
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
2 P14003 (/IDA) Q04666 (/IDA)
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
2 P35428 (/ISO) P35428 (/ISO)
N-box binding GO:0071820
Interacting selectively and non-covalently with an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses.
2 P35428 (/ISO) P35428 (/ISO)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 P14003 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 P35429 (/IMP)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 O54792 (/ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 G5EF76 (/ISS)
Transcription corepressor binding GO:0001222
Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
1 Q6XLQ0 (/IPI)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P35429 (/IMP)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 O54792 (/ISO)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q04666 (/IDA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 P35429 (/IDA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 O54792 (/ISO)
Beta-galactosidase activity GO:0004565
Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.
1 Q6XLQ0 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 Q04666 (/IDA)
JUN kinase binding GO:0008432
Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.
1 Q04666 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q04666 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 O57337 (/IDA)

There are 225 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
30 F1QI81 (/IDA) P13097 (/IDA) P14003 (/IDA) P35428 (/IDA) P35428 (/IDA) P35429 (/IDA) Q01070 (/IDA) Q01070 (/IDA) Q01071 (/IDA) Q01071 (/IDA)
(20 more)
Forebrain radial glial cell differentiation GO:0021861
The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
30 P35428 (/ISS) P35428 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(20 more)
Negative regulation of forebrain neuron differentiation GO:2000978
Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation.
30 P35428 (/ISS) P35428 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(20 more)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
29 Q04666 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(19 more)
Positive regulation of DNA binding GO:0043388
Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
29 Q04666 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(19 more)
Regulation of receptor signaling pathway via JAK-STAT GO:0046425
Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT.
29 Q04666 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(19 more)
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
29 Q04666 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(19 more)
Positive regulation of astrocyte differentiation GO:0048711
Any process that activates or increases the frequency, rate or extent of astrocyte differentiation.
29 Q04666 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(19 more)
Negative regulation of oligodendrocyte differentiation GO:0048715
Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.
29 Q04666 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(19 more)
Negative regulation of glial cell proliferation GO:0060253
Any process that stops or decreases the rate or extent of glial cell proliferation.
29 Q04666 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(19 more)
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
29 Q04666 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(19 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
22 F1QI81 (/IMP) P13097 (/IMP) P14003 (/IMP) P35428 (/IMP) P35428 (/IMP) Q00P32 (/IMP) Q00P32 (/IMP) Q01069 (/IMP) Q01070 (/IMP) Q01070 (/IMP)
(12 more)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
20 A0A2R8Q6M1 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP)
(10 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
18 P14003 (/IDA) P35429 (/IDA) Q04666 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA)
(8 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
17 Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS)
(7 more)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
17 P35428 (/IDA) P35428 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA)
(7 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
17 Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS)
(7 more)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
16 P14003 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS)
(6 more)
Negative regulation of pro-B cell differentiation GO:2000974
Any process that stops, prevents or reduces the frequency, rate or extent of pro-B cell differentiation.
16 P35428 (/ISS) P35428 (/ISS) Q04666 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS) Q3ZBG4 (/ISS)
(6 more)
Embryonic heart tube morphogenesis GO:0003143
The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
15 Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(5 more)
Outflow tract morphogenesis GO:0003151
The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
15 Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(5 more)
Ventricular septum development GO:0003281
The progression of the ventricular septum over time from its formation to the mature structure.
15 Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(5 more)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
15 Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(5 more)
Ascending aorta morphogenesis GO:0035910
The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.
15 Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(5 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
15 Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS)
(5 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
15 Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(5 more)
Positive regulation of mitotic cell cycle, embryonic GO:0045977
Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle.
15 Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(5 more)
Thymus development GO:0048538
The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.
15 Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(5 more)
Artery morphogenesis GO:0048844
The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.
15 Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(5 more)
Ventricular septum morphogenesis GO:0060412
The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another.
15 Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(5 more)
Pharyngeal arch artery morphogenesis GO:0061626
The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery.
15 Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(5 more)
Vascular smooth muscle cell development GO:0097084
The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.
15 Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(5 more)
Neuronal stem cell population maintenance GO:0097150
Any process in by an organism or tissue maintains a population of neuronal stem cells.
15 Q14469 (/IEP) Q14469 (/IEP) Q14469 (/IEP) Q14469 (/IEP) Q14469 (/IEP) Q14469 (/IEP) Q14469 (/IEP) Q14469 (/IEP) Q14469 (/IEP) Q14469 (/IEP)
(5 more)
Negative regulation of stem cell differentiation GO:2000737
Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.
15 Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP)
(5 more)
Negative regulation of pro-B cell differentiation GO:2000974
Any process that stops, prevents or reduces the frequency, rate or extent of pro-B cell differentiation.
15 Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP) Q14469 (/IMP)
(5 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
9 P35428 (/IMP) P35428 (/IMP) Q00P32 (/IMP) Q00P32 (/IMP) Q6IRB2 (/IMP) Q6IRB2 (/IMP) Q90VV1 (/IMP) Q90VV1 (/IMP) Q90Z12 (/IMP)
Negative regulation of neurogenesis GO:0050768
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
8 A7MCR9 (/IMP) F1QI81 (/IMP) Q00P32 (/IMP) Q00P32 (/IMP) Q04666 (/IMP) Q9DEU7 (/IMP) Q9DEU8 (/IMP) Q9DF41 (/IMP)
Regulation of neuroblast proliferation GO:1902692
Any process that modulates the frequency, rate or extent of neuroblast proliferation.
7 Q01069 (/IGI) Q01070 (/IGI) Q01070 (/IGI) Q01071 (/IGI) Q01071 (/IGI) Q01071 (/IGI) Q26263 (/IGI)
Regulation of neuroblast proliferation GO:1902692
Any process that modulates the frequency, rate or extent of neuroblast proliferation.
7 Q01069 (/IMP) Q01070 (/IMP) Q01070 (/IMP) Q01071 (/IMP) Q01071 (/IMP) Q01071 (/IMP) Q26263 (/IMP)
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
6 Q01068 (/IMP) Q01068 (/IMP) Q01069 (/IMP) Q01070 (/IMP) Q01070 (/IMP) Q26263 (/IMP)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
4 A0A2R8Q6M1 (/IMP) G5EF76 (/IMP) Q6PBX3 (/IMP) Q90468 (/IMP)
Neuronal stem cell population maintenance GO:0097150
Any process in by an organism or tissue maintains a population of neuronal stem cells.
4 P35428 (/IMP) P35428 (/IMP) Q01070 (/IMP) Q01070 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 O54792 (/ISO) P35428 (/ISO) P35428 (/ISO)
Somite specification GO:0001757
The process in which individual somites establish identity during embryogenesis.
3 A0A2R8Q6M1 (/IMP) Q6PBX3 (/IMP) Q90468 (/IMP)
Lens development in camera-type eye GO:0002088
The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
3 Q90VV1 (/IMP) Q90VV1 (/IMP) Q90Z12 (/IMP)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 Q5PPM5 (/ISS) Q8AVU4 (/ISS) Q8AVU4 (/ISS)
Somatic muscle development GO:0007525
The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.
3 Q01071 (/IMP) Q01071 (/IMP) Q01071 (/IMP)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
3 Q90VV1 (/IMP) Q90VV1 (/IMP) Q90Z12 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 G5EF76 (/IMP) Q04666 (/IMP) Q26263 (/IMP)
Neural crest formation GO:0014029
The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.
3 Q90VV1 (/IMP) Q90VV1 (/IMP) Q90Z12 (/IMP)
Prechordal plate formation GO:0021501
The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells.
3 Q90VV1 (/IMP) Q90VV1 (/IMP) Q90Z12 (/IMP)
Thalamus development GO:0021794
The process in which the thalamus changes over time, from its initial formation to its mature state.
3 A0A2R8Q6M1 (/IMP) Q6PBX3 (/IMP) Q90468 (/IMP)
Floor plate development GO:0033504
The progression of the floor plate over time from its initial formation until its mature state.
3 Q90VV1 (/IMP) Q90VV1 (/IMP) Q90Z12 (/IMP)
Gliogenesis GO:0042063
The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.
3 F1QI81 (/IMP) Q9DEU7 (/IMP) Q9DEU8 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
3 Q90VV1 (/IMP) Q90VV1 (/IMP) Q90Z12 (/IMP)
R7 cell differentiation GO:0045466
The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor.
3 Q01071 (/IMP) Q01071 (/IMP) Q01071 (/IMP)
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
3 A0A2R8Q6M1 (/IMP) Q6PBX3 (/IMP) Q90468 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
3 O54792 (/ISO) P35428 (/ISO) P35428 (/ISO)
R1/R6 cell differentiation GO:0048052
The process in which relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster.
3 Q01071 (/IMP) Q01071 (/IMP) Q01071 (/IMP)
Negative regulation of muscle organ development GO:0048635
Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development.
3 Q5PPM5 (/ISS) Q8AVU4 (/ISS) Q8AVU4 (/ISS)
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
3 A0A2R8Q6M1 (/IMP) Q6PBX3 (/IMP) Q90468 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P35428 (/IGI) P35428 (/IGI)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
2 P35428 (/IGI) P35428 (/IGI)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
2 P35428 (/IMP) P35428 (/IMP)
Embryonic heart tube morphogenesis GO:0003143
The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.
2 P35428 (/IMP) P35428 (/IMP)
Outflow tract morphogenesis GO:0003151
The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
2 P35428 (/IMP) P35428 (/IMP)
Regulation of secondary heart field cardioblast proliferation GO:0003266
Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract).
2 P35428 (/IMP) P35428 (/IMP)
Ventricular septum development GO:0003281
The progression of the ventricular septum over time from its formation to the mature structure.
2 P35428 (/IMP) P35428 (/IMP)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P35428 (/IGI) P35428 (/IGI)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
2 P35428 (/IGI) P35428 (/IGI)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P35428 (/ISO) P35428 (/ISO)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P35428 (/NAS) P35428 (/NAS)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P35428 (/TAS) P35428 (/TAS)
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2 P35428 (/IDA) P35428 (/IDA)
Pattern specification process GO:0007389
Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
2 P35428 (/IGI) P35428 (/IGI)
Pattern specification process GO:0007389
Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
2 P35428 (/IMP) P35428 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 P35428 (/IMP) P35428 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P35428 (/ISO) P35428 (/ISO)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P35428 (/ISO) P35428 (/ISO)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 P35428 (/ISO) P35428 (/ISO)
Positive regulation of gliogenesis GO:0014015
Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia.
2 Q00P32 (/IMP) Q00P32 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 P35428 (/IGI) P35428 (/IGI)
Telencephalon development GO:0021537
The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.
2 P35428 (/IGI) P35428 (/IGI)
Telencephalon development GO:0021537
The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.
2 P35428 (/IMP) P35428 (/IMP)
Midbrain-hindbrain boundary morphogenesis GO:0021555
The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2 P35428 (/IGI) P35428 (/IGI)
Oculomotor nerve development GO:0021557
The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.
2 P35428 (/IGI) P35428 (/IGI)
Trochlear nerve development GO:0021558
The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle.
2 P35428 (/IGI) P35428 (/IGI)
Hindbrain morphogenesis GO:0021575
The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
2 P35428 (/IGI) P35428 (/IGI)
Forebrain radial glial cell differentiation GO:0021861
The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2 P35428 (/ISO) P35428 (/ISO)
Neural tube development GO:0021915
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
2 P35428 (/IGI) P35428 (/IGI)
Pituitary gland development GO:0021983
The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.
2 P35428 (/IGI) P35428 (/IGI)
Pituitary gland development GO:0021983
The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.
2 P35428 (/IMP) P35428 (/IMP)
Adenohypophysis development GO:0021984
The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus.
2 P35428 (/IMP) P35428 (/IMP)
Lung development GO:0030324
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
2 P35428 (/IMP) P35428 (/IMP)
Positive regulation of BMP signaling pathway GO:0030513
Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
2 P35428 (/IGI) P35428 (/IGI)
Midbrain development GO:0030901
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
2 P35428 (/IGI) P35428 (/IGI)
Pancreas development GO:0031016
The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.
2 P35428 (/IMP) P35428 (/IMP)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
2 P35428 (/TAS) P35428 (/TAS)
Somatic stem cell population maintenance GO:0035019
Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
2 P35428 (/IMP) P35428 (/IMP)
Hair cell differentiation GO:0035315
The process in which a relatively unspecialized cell acquires specialized features of a hair cell.
2 P35428 (/ISO) P35428 (/ISO)
Aorta morphogenesis GO:0035909
The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.
2 P35428 (/IMP) P35428 (/IMP)
Ascending aorta morphogenesis GO:0035910
The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.
2 P35428 (/IMP) P35428 (/IMP)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
2 P35428 (/IMP) P35428 (/IMP)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
2 P35428 (/IDA) P35428 (/IDA)
Positive regulation of DNA binding GO:0043388
Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
2 P35428 (/IDA) P35428 (/IDA)
Regulation of protein heterodimerization activity GO:0043497
Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer.
2 P35428 (/ISO) P35428 (/ISO)
Cell fate commitment GO:0045165
The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
2 P35428 (/IMP) P35428 (/IMP)
Negative regulation of cell differentiation GO:0045596
Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.
2 P35428 (/IMP) P35428 (/IMP)
Regulation of fat cell differentiation GO:0045598
Any process that modulates the frequency, rate or extent of adipocyte differentiation.
2 P35428 (/IMP) P35428 (/IMP)
Negative regulation of inner ear auditory receptor cell differentiation GO:0045608
Any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation.
2 P35428 (/IGI) P35428 (/IGI)
Negative regulation of inner ear auditory receptor cell differentiation GO:0045608
Any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation.
2 P35428 (/IMP) P35428 (/IMP)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
2 P35428 (/IGI) P35428 (/IGI)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
2 P35428 (/IMP) P35428 (/IMP)
Positive regulation of glial cell differentiation GO:0045687
Any process that activates or increases the frequency, rate or extent of glia cell differentiation.
2 P35428 (/ISO) P35428 (/ISO)
Positive regulation of Notch signaling pathway GO:0045747
Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
2 P35428 (/IMP) P35428 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P35428 (/IMP) P35428 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P35428 (/IGI) P35428 (/IGI)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P35428 (/IMP) P35428 (/IMP)
Positive regulation of mitotic cell cycle, embryonic GO:0045977
Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle.
2 P35428 (/IMP) P35428 (/IMP)
Lateral inhibition GO:0046331
Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells.
2 P35428 (/IMP) P35428 (/IMP)
Regulation of receptor signaling pathway via JAK-STAT GO:0046425
Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT.
2 P35428 (/IDA) P35428 (/IDA)
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
2 P35428 (/IDA) P35428 (/IDA)
Wing disc dorsal/ventral pattern formation GO:0048190
The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing.
2 Q01070 (/IGI) Q01070 (/IGI)
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
2 P35428 (/IGI) P35428 (/IGI)
Regulation of timing of cell differentiation GO:0048505
The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development.
2 P35428 (/IMP) P35428 (/IMP)
Thymus development GO:0048538
The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.
2 P35428 (/IMP) P35428 (/IMP)
Negative regulation of muscle organ development GO:0048635
Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development.
2 Q6IRB2 (/IMP) Q6IRB2 (/IMP)
Negative regulation of skeletal muscle tissue development GO:0048642
Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development.
2 Q90VV1 (/IMP) Q90VV1 (/IMP)
Cell morphogenesis involved in neuron differentiation GO:0048667
The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.
2 P35428 (/IGI) P35428 (/IGI)
Positive regulation of astrocyte differentiation GO:0048711
Any process that activates or increases the frequency, rate or extent of astrocyte differentiation.
2 P35428 (/IDA) P35428 (/IDA)
Negative regulation of oligodendrocyte differentiation GO:0048715
Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.
2 P35428 (/IDA) P35428 (/IDA)
Negative regulation of oligodendrocyte differentiation GO:0048715
Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.
2 P35428 (/ISO) P35428 (/ISO)
Artery morphogenesis GO:0048844
The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.
2 P35428 (/IMP) P35428 (/IMP)
Regulation of epithelial cell proliferation GO:0050678
Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
2 P35428 (/IGI) P35428 (/IGI)
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
2 P35428 (/IGI) P35428 (/IGI)
Negative regulation of neurogenesis GO:0050768
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
2 P35428 (/ISO) P35428 (/ISO)
Retina morphogenesis in camera-type eye GO:0060042
The process in which the anatomical structure of the retina is generated and organized.
2 Q00P32 (/IMP) Q00P32 (/IMP)
Inner ear receptor cell stereocilium organization GO:0060122
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells.
2 P35428 (/IGI) P35428 (/IGI)
Regulation of timing of neuron differentiation GO:0060164
The process controlling the activation and/or rate at which a relatively unspecialized cell acquires features of a neuron.
2 P35428 (/IGI) P35428 (/IGI)
Regulation of timing of neuron differentiation GO:0060164
The process controlling the activation and/or rate at which a relatively unspecialized cell acquires features of a neuron.
2 P35428 (/IMP) P35428 (/IMP)
Negative regulation of glial cell proliferation GO:0060253
Any process that stops or decreases the rate or extent of glial cell proliferation.
2 P35428 (/IDA) P35428 (/IDA)
Ventricular septum morphogenesis GO:0060412
The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another.
2 P35428 (/IMP) P35428 (/IMP)
Ureteric bud morphogenesis GO:0060675
The process in which the ureteric bud is generated and organized.
2 P35428 (/IEP) P35428 (/IEP)
Labyrinthine layer blood vessel development GO:0060716
The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.
2 P35428 (/IMP) P35428 (/IMP)
Common bile duct development GO:0061009
The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gall bladder. The common bile duct transports bile from the liver and gall bladder to the intestine.
2 P35428 (/IMP) P35428 (/IMP)
Negative regulation of stomach neuroendocrine cell differentiation GO:0061106
Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.
2 P35428 (/IMP) P35428 (/IMP)
Cardiac neural crest cell development involved in outflow tract morphogenesis GO:0061309
The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract.
2 P35428 (/IMP) P35428 (/IMP)
Pharyngeal arch artery morphogenesis GO:0061626
The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery.
2 P35428 (/IMP) P35428 (/IMP)
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
2 P35428 (/IDA) P35428 (/IDA)
Glomerulus vasculature development GO:0072012
The biological process whose specific outcome is the progression of a glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the glomerulus vasculature and ends with the mature structure. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus.
2 P35428 (/IEP) P35428 (/IEP)
Comma-shaped body morphogenesis GO:0072049
The process in which the comma-shaped body is generated and organized. The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron.
2 P35428 (/IEP) P35428 (/IEP)
S-shaped body morphogenesis GO:0072050
The process in which the S-shaped body is generated and organized. The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron.
2 P35428 (/IEP) P35428 (/IEP)
Renal interstitial fibroblast development GO:0072141
The process whose specific outcome is the progression of a renal interstitial fibroblast over time, from its formation to the mature structure.
2 P35428 (/IEP) P35428 (/IEP)
Metanephric nephron tubule morphogenesis GO:0072282
The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros.
2 P35428 (/IEP) P35428 (/IEP)
Cochlea development GO:0090102
The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound.
2 P35428 (/IGI) P35428 (/IGI)
Cochlea development GO:0090102
The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound.
2 P35428 (/IMP) P35428 (/IMP)
Establishment of epithelial cell polarity GO:0090162
The specification and formation of anisotropic intracellular organization of an epithelial cell.
2 P35428 (/IGI) P35428 (/IGI)
Negative regulation of calcium ion import GO:0090281
Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
2 P35428 (/ISO) P35428 (/ISO)
Vascular smooth muscle cell development GO:0097084
The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.
2 P35428 (/IMP) P35428 (/IMP)
Neuronal stem cell population maintenance GO:0097150
Any process in by an organism or tissue maintains a population of neuronal stem cells.
2 Q01070 (/IGI) Q01070 (/IGI)
Neuronal stem cell population maintenance GO:0097150
Any process in by an organism or tissue maintains a population of neuronal stem cells.
2 P35428 (/ISO) P35428 (/ISO)
Negative regulation of cell fate determination GO:1905934
Any process that stops, prevents or reduces the frequency, rate or extent of cell fate determination.
2 P35428 (/IMP) P35428 (/IMP)
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
2 P35428 (/ISO) P35428 (/ISO)
Negative regulation of pancreatic A cell differentiation GO:2000227
Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation.
2 P35428 (/IMP) P35428 (/IMP)
Negative regulation of stem cell differentiation GO:2000737
Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.
2 P35428 (/ISO) P35428 (/ISO)
Negative regulation of pro-B cell differentiation GO:2000974
Any process that stops, prevents or reduces the frequency, rate or extent of pro-B cell differentiation.
2 P35428 (/ISO) P35428 (/ISO)
Negative regulation of forebrain neuron differentiation GO:2000978
Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation.
2 P35428 (/ISO) P35428 (/ISO)
Negative regulation of inner ear receptor cell differentiation GO:2000981
Any process that stops, prevents or reduces the frequency, rate or extent of inner ear receptor cell differentiation.
2 P35428 (/IMP) P35428 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q01069 (/IEP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P14003 (/IPI)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
1 P14003 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P14003 (/IMP)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
1 Q6XLQ0 (/TAS)
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
1 Q26263 (/IGI)
Lens development in camera-type eye GO:0002088
The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
1 Q6PBD4 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P35429 (/TAS)
Periodic partitioning by pair rule gene GO:0007366
Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities.
1 P14003 (/NAS)
Periodic partitioning by pair rule gene GO:0007366
Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities.
1 P14003 (/TAS)
Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
1 P14003 (/IMP)
Salivary gland development GO:0007431
The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.
1 P14003 (/TAS)
Salivary gland morphogenesis GO:0007435
The process in which the anatomical structures of the salivary gland are generated and organized.
1 P14003 (/IGI)
Salivary gland morphogenesis GO:0007435
The process in which the anatomical structures of the salivary gland are generated and organized.
1 P14003 (/IMP)
Salivary gland morphogenesis GO:0007435
The process in which the anatomical structures of the salivary gland are generated and organized.
1 P14003 (/TAS)
Sex determination, establishment of X:A ratio GO:0007540
The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it.
1 Q26263 (/IGI)
Sex determination, establishment of X:A ratio GO:0007540
The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it.
1 Q26263 (/IMP)
Dosage compensation GO:0007549
Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes.
1 Q26263 (/IMP)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q6PBD4 (/ISS)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
1 Q26263 (/IMP)
Larval locomotory behavior GO:0008345
Locomotory behavior in a larval (immature) organism.
1 Q26263 (/IMP)
Epidermal cell fate specification GO:0009957
The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
1 G5EF76 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q04666 (/IMP)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q04666 (/IMP)
Neuroblast development GO:0014019
The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron.
1 Q26263 (/IMP)
Neural crest formation GO:0014029
The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.
1 Q6PBD4 (/ISS)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 Q04666 (/IEP)
Prechordal plate formation GO:0021501
The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells.
1 Q6PBD4 (/ISS)
Forebrain radial glial cell differentiation GO:0021861
The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
1 Q04666 (/IDA)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 Q04666 (/IEP)
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q90Z12 (/IMP)
Regulation of cellular metabolic process GO:0031323
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
1 P14003 (/IMP)
Floor plate development GO:0033504
The progression of the floor plate over time from its initial formation until its mature state.
1 Q6PBD4 (/ISS)
Tube morphogenesis GO:0035239
The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
1 P14003 (/IMP)
Posterior head segmentation GO:0035289
Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains.
1 P14003 (/TAS)
Trunk segmentation GO:0035290
Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8.
1 P14003 (/TAS)
Hair cell differentiation GO:0035315
The process in which a relatively unspecialized cell acquires specialized features of a hair cell.
1 Q04666 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q6PBD4 (/ISS)
Response to alkaloid GO:0043279
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.
1 Q04666 (/IEP)
Regulation of protein heterodimerization activity GO:0043497
Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer.
1 Q04666 (/IDA)
Nematode male tail tip morphogenesis GO:0045138
The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome.
1 G5EF76 (/IMP)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
1 O57337 (/IEP)
Positive regulation of glial cell differentiation GO:0045687
Any process that activates or increases the frequency, rate or extent of glia cell differentiation.
1 Q04666 (/IMP)
Positive regulation of mitotic nuclear division GO:0045840
Any process that activates or increases the frequency, rate or extent of mitosis.
1 Q26263 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 P14003 (/TAS)
Negative regulation of skeletal muscle tissue development GO:0048642
Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development.
1 Q6PBD4 (/ISS)
Negative regulation of oligodendrocyte differentiation GO:0048715
Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.
1 Q04666 (/IMP)
Limb development GO:0060173
The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.
1 Q6XLQ0 (/TAS)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
1 P14003 (/TAS)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 Q04666 (/IEP)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 Q04666 (/IEP)
Cellular response to fatty acid GO:0071398
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
1 Q04666 (/IEP)
Negative regulation of calcium ion import GO:0090281
Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
1 Q04666 (/IMP)
Response to thyroid hormone GO:0097066
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
1 Q04666 (/IEP)
Neuronal stem cell population maintenance GO:0097150
Any process in by an organism or tissue maintains a population of neuronal stem cells.
1 Q04666 (/IDA)
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
1 Q04666 (/IMP)
Negative regulation of forebrain neuron differentiation GO:2000978
Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation.
1 Q04666 (/IDA)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
41 G5EF76 (/ISS) Q00P32 (/ISS) Q00P32 (/ISS) Q04666 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS) Q14469 (/ISS)
(31 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
18 P35428 (/IDA) P35428 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA) Q14469 (/IDA)
(8 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
18 P35428 (/TAS) P35428 (/TAS) Q04666 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS) Q14469 (/TAS)
(8 more)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
4 F1QI81 (/IDA) Q04666 (/IDA) Q9DEU7 (/IDA) Q9DEU8 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 Q01069 (/IMP) Q01070 (/IMP) Q01070 (/IMP) Q26263 (/IMP)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
2 P35428 (/ISO) P35428 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P35428 (/ISO) P35428 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P35428 (/IDA) P35428 (/IDA)
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
2 P35428 (/ISO) P35428 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P14003 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P35429 (/TAS)
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
1 Q04666 (/IDA)
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