The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Helix-loop-helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 78: Transcription factor bHLH13

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
12 O23487 (/ISS) O23487 (/ISS) O49687 (/ISS) Q39204 (/ISS) Q39204 (/ISS) Q9FIP9 (/ISS) Q9LNJ5 (/ISS) Q9LNJ5 (/ISS) Q9LUK7 (/ISS) Q9LUK7 (/ISS)
(2 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 O23487 (/IPI) O23487 (/IPI) O49687 (/IPI) Q39204 (/IPI) Q39204 (/IPI) Q9FIP9 (/IPI) Q9LNJ5 (/IPI) Q9LNJ5 (/IPI) Q9ZPY8 (/IPI) Q9ZPY8 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
4 Q39204 (/IDA) Q39204 (/IDA) Q9LUK7 (/IDA) Q9LUK7 (/IDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
4 Q39204 (/IPI) Q39204 (/IPI) Q9LNJ5 (/IPI) Q9LNJ5 (/IPI)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 Q9ZPY8 (/IDA) Q9ZPY8 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 Q9LUK7 (/TAS) Q9LUK7 (/TAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 Q9LUK7 (/IDA) Q9LUK7 (/IDA)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
2 Q39204 (/IPI) Q39204 (/IPI)
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
2 O49687 (/IPI) Q9FIP9 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 Q39204 (/IDA) Q39204 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 Q39204 (/IPI) Q39204 (/IPI)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
10 O23487 (/TAS) O23487 (/TAS) O49687 (/TAS) Q9FIP9 (/TAS) Q9LNJ5 (/TAS) Q9LNJ5 (/TAS) Q9LUK7 (/TAS) Q9LUK7 (/TAS) Q9ZPY8 (/TAS) Q9ZPY8 (/TAS)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
6 O23487 (/IGI) O23487 (/IGI) Q9LNJ5 (/IGI) Q9LNJ5 (/IGI) Q9ZPY8 (/IGI) Q9ZPY8 (/IGI)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
4 Q39204 (/IEP) Q39204 (/IEP) Q9ZPY8 (/IEP) Q9ZPY8 (/IEP)
Stomatal complex development GO:0010374
The process whose specific outcome is the progression of the stomatal complex over time from its formation to the mature structure. The stomatal complex is the stomatal guard cells and their associated epidermal cells.
4 O49687 (/IGI) Q39204 (/IGI) Q39204 (/IGI) Q9FIP9 (/IGI)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
4 O49687 (/IDA) Q39204 (/IDA) Q39204 (/IDA) Q9FIP9 (/IDA)
Extracellular ATP signaling GO:0106167
A series of molecular signals mediated by the detection of extracellular ATP.
4 O49687 (/IMP) Q39204 (/IMP) Q39204 (/IMP) Q9FIP9 (/IMP)
Response to jasmonic acid GO:0009753
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.
3 Q39204 (/IMP) Q39204 (/IMP) Q9FIP9 (/IMP)
Regulation of secondary cell wall biogenesis GO:2000652
Any process that modulates the frequency, rate or extent of secondary cell wall biogenesis.
3 O49687 (/IMP) Q39204 (/IMP) Q39204 (/IMP)
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
2 O49687 (/IMP) Q9FIP9 (/IMP)
Response to desiccation GO:0009269
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water.
2 Q39204 (/IEP) Q39204 (/IEP)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
2 Q39204 (/TAS) Q39204 (/TAS)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
2 Q9LUK7 (/IEP) Q9LUK7 (/IEP)
Anthocyanin-containing compound biosynthetic process GO:0009718
The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins.
2 O49687 (/IMP) Q9FIP9 (/IMP)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
2 Q39204 (/IEP) Q39204 (/IEP)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
2 Q9ZPY8 (/IMP) Q9ZPY8 (/IMP)
Positive regulation of flavonoid biosynthetic process GO:0009963
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids.
2 Q39204 (/IEP) Q39204 (/IEP)
Response to chitin GO:0010200
A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus.
2 Q39204 (/IEP) Q39204 (/IEP)
Hyperosmotic salinity response GO:0042538
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
2 Q9LUK7 (/IMP) Q9LUK7 (/IMP)
Regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043619
Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
2 Q39204 (/IMP) Q39204 (/IMP)
Regulation of DNA-binding transcription factor activity GO:0051090
Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
2 Q39204 (/IMP) Q39204 (/IMP)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
2 Q39204 (/IDA) Q39204 (/IDA)
Regulation of defense response to insect GO:2000068
Any process that modulates the frequency, rate or extent of defense response to insect.
2 Q39204 (/IMP) Q39204 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
12 O23487 (/IDA) O23487 (/IDA) O49687 (/IDA) Q39204 (/IDA) Q39204 (/IDA) Q9FIP9 (/IDA) Q9LNJ5 (/IDA) Q9LNJ5 (/IDA) Q9LUK7 (/IDA) Q9LUK7 (/IDA)
(2 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9LNJ5 (/IDA) Q9LNJ5 (/IDA)
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