The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Helix-loop-helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 66: BHLH transcription factor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
7 Q9LPW3 (/ISS) Q9LSE2 (/ISS) Q9LSE2 (/ISS) Q9LSE2 (/ISS) Q9LSL1 (/ISS) Q9LXA9 (/ISS) Q9ZVX2 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 Q6YUS3 (/IPI) Q9LPW3 (/IPI) Q9LSE2 (/IPI) Q9LSE2 (/IPI) Q9LSE2 (/IPI) Q9ZVX2 (/IPI)
Core promoter sequence-specific DNA binding GO:0001046
Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
3 Q9LSE2 (/IPI) Q9LSE2 (/IPI) Q9LSE2 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 Q9LSE2 (/IDA) Q9LSE2 (/IDA) Q9LSE2 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 Q9LSE2 (/TAS) Q9LSE2 (/TAS) Q9LSE2 (/TAS)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q9ZVX2 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q6YUS3 (/IMP)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q9ZVX2 (/IDA)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to freezing GO:0050826
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius.
4 Q9LPW3 (/IMP) Q9LSE2 (/IMP) Q9LSE2 (/IMP) Q9LSE2 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
3 Q9LPW3 (/TAS) Q9LXA9 (/TAS) Q9ZVX2 (/TAS)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
3 Q9LSE2 (/IEP) Q9LSE2 (/IEP) Q9LSE2 (/IEP)
Endosperm development GO:0009960
The process whose specific outcome is the progression of the endosperm over time, from its formation to the mature structure. The endosperm is formed during fertilization and provides nutrients to the developing embryo.
3 Q9LSE2 (/IGI) Q9LSE2 (/IGI) Q9LSE2 (/IGI)
Regulation of abscisic acid biosynthetic process GO:0010115
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid.
3 Q9LSE2 (/IMP) Q9LSE2 (/IMP) Q9LSE2 (/IMP)
Seed dormancy process GO:0010162
A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a seed. Seed dormancy is a suspension of most physiological activity and growth in a seed, including the embryo contained therein, that can be reactivated. It often requires special conditions for reactivation, such as specific temperature, scarification, or leaching of inhibitors.
3 Q9LSE2 (/IGI) Q9LSE2 (/IGI) Q9LSE2 (/IGI)
Seed dormancy process GO:0010162
A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a seed. Seed dormancy is a suspension of most physiological activity and growth in a seed, including the embryo contained therein, that can be reactivated. It often requires special conditions for reactivation, such as specific temperature, scarification, or leaching of inhibitors.
3 Q9LSE2 (/IMP) Q9LSE2 (/IMP) Q9LSE2 (/IMP)
Stomatal lineage progression GO:0010440
The process in which an unspecialized epidermal cell progresses through a series of divisions that culminate in the production of a stomatal complex.
3 Q9LSE2 (/IMP) Q9LSE2 (/IMP) Q9LSE2 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
3 Q9LSE2 (/IMP) Q9LSE2 (/IMP) Q9LSE2 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
3 Q9LSE2 (/IDA) Q9LSE2 (/IDA) Q9LSE2 (/IDA)
Seed morphogenesis GO:0048317
The process in which the anatomical structures of the seed are generated and organized.
3 Q9LSE2 (/IGI) Q9LSE2 (/IGI) Q9LSE2 (/IGI)
Seed morphogenesis GO:0048317
The process in which the anatomical structures of the seed are generated and organized.
3 Q9LSE2 (/IMP) Q9LSE2 (/IMP) Q9LSE2 (/IMP)
Pollen development GO:0009555
The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
1 Q9ZVX2 (/IGI)
Pollen development GO:0009555
The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
1 Q9ZVX2 (/IMP)
Regulation of gibberellin biosynthetic process GO:0010371
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins.
1 Q9LSL1 (/IMP)
Guard mother cell differentiation GO:0010444
The process in which a meristemoid acquires the specialized features of a guard mother cell.
1 Q9LPW3 (/IMP)
Gibberellin catabolic process GO:0045487
The chemical reactions and pathways resulting in the breakdown of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators.
1 Q9LSL1 (/IMP)
Anther development GO:0048653
The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure.
1 Q6YUS3 (/IMP)
Anther morphogenesis GO:0048654
The process in which the anatomical structures of the anther are generated and organized.
1 Q6YUS3 (/IMP)
Anther wall tapetum cell differentiation GO:0048657
The process in which a relatively unspecialized cell acquires specialized features of an anther cell wall tapetum cell. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature.
1 Q6YUS3 (/IMP)
Anther wall tapetum development GO:0048658
The process whose specific outcome is the progression of the anther wall tapetum over time, from its formation to the mature structure.
1 Q9ZVX2 (/IMP)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 Q6YUS3 (/IDA) Q9LSE2 (/IDA) Q9LSE2 (/IDA) Q9LSE2 (/IDA) Q9LSL1 (/IDA) Q9ZVX2 (/IDA)
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