The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Helix-loop-helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Neurogenic differentiation factor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 46 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
40 Q13562 (/ISA) Q13562 (/ISA) Q15784 (/ISA) Q15784 (/ISA) Q15784 (/ISA) Q92886 (/ISA) Q92886 (/ISA) Q96NK8 (/ISA) Q96NK8 (/ISA) Q96NK8 (/ISA)
(30 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
40 Q13562 (/ISM) Q13562 (/ISM) Q15784 (/ISM) Q15784 (/ISM) Q15784 (/ISM) Q92886 (/ISM) Q92886 (/ISM) Q96NK8 (/ISM) Q96NK8 (/ISM) Q96NK8 (/ISM)
(30 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
37 Q13562 (/NAS) Q13562 (/NAS) Q15784 (/NAS) Q15784 (/NAS) Q15784 (/NAS) Q92886 (/NAS) Q92886 (/NAS) Q96NK8 (/NAS) Q96NK8 (/NAS) Q96NK8 (/NAS)
(27 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
14 O42606 (/IPI) P70447 (/IPI) P70447 (/IPI) P70660 (/IPI) P70661 (/IPI) P70661 (/IPI) Q13562 (/IPI) Q13562 (/IPI) Q60867 (/IPI) Q62414 (/IPI)
(4 more)
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
12 O42606 (/ISS) P70595 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q60430 (/ISS) Q60430 (/ISS) Q63689 (/ISS) Q92886 (/ISS) Q92886 (/ISS)
(2 more)
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
10 P70447 (/IDA) P70447 (/IDA) P70660 (/IDA) Q13562 (/IDA) Q13562 (/IDA) Q60867 (/IDA) Q62414 (/IDA) Q62414 (/IDA) Q92886 (/IDA) Q92886 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
9 O42606 (/ISS) P70595 (/ISS) Q13562 (/ISS) Q13562 (/ISS) Q60430 (/ISS) Q60430 (/ISS) Q64289 (/ISS) Q92886 (/ISS) Q92886 (/ISS)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
6 P48986 (/IDA) P48986 (/IDA) P70661 (/IDA) P70661 (/IDA) Q60867 (/IDA) Q9Y4Z2 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
6 O08718 (/IDA) P48986 (/IDA) P48986 (/IDA) Q60867 (/IDA) Q62414 (/IDA) Q62414 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
5 Q15784 (/TAS) Q15784 (/TAS) Q15784 (/TAS) Q92886 (/TAS) Q92886 (/TAS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
5 P79920 (/IPI) Q13562 (/IPI) Q13562 (/IPI) Q60867 (/IPI) Q91616 (/IPI)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
4 P70661 (/IDA) P70661 (/IDA) Q13562 (/IDA) Q13562 (/IDA)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
4 P70661 (/IDA) P70661 (/IDA) Q13562 (/IDA) Q13562 (/IDA)
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
4 Q15784 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q63689 (/ISS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
4 Q13562 (/IDA) Q13562 (/IDA) Q62414 (/IDA) Q62414 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
4 Q15784 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q63689 (/ISS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 Q60867 (/IDA) Q62414 (/IDA) Q62414 (/IDA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
3 P70661 (/ISO) P70661 (/ISO) Q60867 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
3 P70447 (/IDA) P70447 (/IDA) Q60867 (/IDA)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
2 Q62414 (/IDA) Q62414 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
2 P70661 (/ISO) P70661 (/ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 Q13562 (/IDA) Q13562 (/IDA)
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
2 Q13562 (/IPI) Q13562 (/IPI)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 P70661 (/ISO) P70661 (/ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 P70661 (/ISO) P70661 (/ISO)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 P70660 (/IDA) Q60867 (/IDA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
2 O08718 (/IDA) Q64289 (/IDA)
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
2 Q62414 (/IDA) Q62414 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
2 Q13562 (/IPI) Q13562 (/IPI)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
2 P70661 (/IDA) P70661 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q92886 (/IDA) Q92886 (/IDA)
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
2 P70660 (/ISO) Q60867 (/ISO)
Sequence-specific double-stranded DNA binding GO:1990837
Interacting selectively and non-covalently with double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
2 Q92886 (/IDA) Q92886 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q9Y4Z2 (/ISS)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q60867 (/ISO)
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
1 Q60867 (/ISO)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q9Y4Z2 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q60867 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P46581 (/ISS)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
1 Q60867 (/ISO)
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
1 Q9Y4Z2 (/ISS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 Q60867 (/ISO)
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
1 Q9Y4Z2 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P70660 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q60867 (/ISO)
Sequence-specific double-stranded DNA binding GO:1990837
Interacting selectively and non-covalently with double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
1 P70660 (/ISO)

There are 191 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
14 P48986 (/IDA) P48986 (/IDA) P70447 (/IDA) P70447 (/IDA) P70660 (/IDA) P70661 (/IDA) P70661 (/IDA) Q13562 (/IDA) Q13562 (/IDA) Q60867 (/IDA)
(4 more)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
13 O42606 (/ISS) P70595 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q60430 (/ISS) Q60430 (/ISS) Q63689 (/ISS) Q92886 (/ISS) Q92886 (/ISS)
(3 more)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
12 O42606 (/ISS) P70595 (/ISS) Q13562 (/ISS) Q13562 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q60430 (/ISS) Q60430 (/ISS) Q63689 (/ISS)
(2 more)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
10 P70447 (/IDA) P70447 (/IDA) P70660 (/IDA) P70661 (/IDA) P70661 (/IDA) Q13562 (/IDA) Q13562 (/IDA) Q60867 (/IDA) Q62414 (/IDA) Q62414 (/IDA)
Amacrine cell differentiation GO:0035881
The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons.
8 P79766 (/ISS) P79920 (/ISS) Q13562 (/ISS) Q13562 (/ISS) Q60430 (/ISS) Q60430 (/ISS) Q64289 (/ISS) Q9HD90 (/ISS)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
8 P79766 (/ISS) P79920 (/ISS) Q13562 (/ISS) Q13562 (/ISS) Q60430 (/ISS) Q60430 (/ISS) Q64289 (/ISS) Q9HD90 (/ISS)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
7 P70447 (/IDA) P70447 (/IDA) P70660 (/IDA) Q60867 (/IDA) Q62414 (/IDA) Q62414 (/IDA) Q64289 (/IDA)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
6 Q15784 (/TAS) Q15784 (/TAS) Q15784 (/TAS) Q92886 (/TAS) Q92886 (/TAS) Q9Y4Z2 (/TAS)
Cell fate commitment GO:0045165
The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
6 O09105 (/IGI) O09105 (/IGI) P70447 (/IGI) P70447 (/IGI) P70660 (/IGI) Q60867 (/IGI)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
6 O42606 (/ISS) P70595 (/ISS) Q60430 (/ISS) Q60430 (/ISS) Q92886 (/ISS) Q92886 (/ISS)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
5 Q15784 (/TAS) Q15784 (/TAS) Q15784 (/TAS) Q92886 (/TAS) Q92886 (/TAS)
Dentate gyrus development GO:0021542
The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus.
5 Q13562 (/ISS) Q13562 (/ISS) Q60430 (/ISS) Q60430 (/ISS) Q64289 (/ISS)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
5 Q13562 (/ISS) Q13562 (/ISS) Q60430 (/ISS) Q60430 (/ISS) Q64289 (/ISS)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
5 P70661 (/TAS) P70661 (/TAS) Q13562 (/TAS) Q13562 (/TAS) Q60867 (/TAS)
Enteroendocrine cell differentiation GO:0035883
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.
5 Q13562 (/ISS) Q13562 (/ISS) Q60430 (/ISS) Q60430 (/ISS) Q64289 (/ISS)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
5 Q13562 (/ISS) Q13562 (/ISS) Q60430 (/ISS) Q60430 (/ISS) Q64289 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
5 Q13562 (/ISS) Q13562 (/ISS) Q60430 (/ISS) Q60430 (/ISS) Q64289 (/ISS)
Inner ear development GO:0048839
The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.
5 Q13562 (/ISS) Q13562 (/ISS) Q60430 (/ISS) Q60430 (/ISS) Q64289 (/ISS)
Regulation of intestinal epithelial structure maintenance GO:0060730
Any process that modulates the rate, frequency, or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.
5 Q13562 (/ISS) Q13562 (/ISS) Q60430 (/ISS) Q60430 (/ISS) Q64289 (/ISS)
Regulation of cell cycle arrest GO:0071156
Any process that modulates the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.
5 Q13562 (/ISS) Q13562 (/ISS) Q60430 (/ISS) Q60430 (/ISS) Q64289 (/ISS)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
4 O09105 (/IMP) O09105 (/IMP) P70447 (/IMP) P70447 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
4 F1QWM8 (/IGI) O42606 (/IGI) Q8JH35 (/IGI) Q9DE43 (/IGI)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
4 Q15784 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q63689 (/ISS)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
4 Q13562 (/ISS) Q13562 (/ISS) Q60430 (/ISS) Q60430 (/ISS)
Cerebellar cortex development GO:0021695
The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
4 Q15784 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q63689 (/ISS)
Habenula development GO:0021986
The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland.
4 F1QWM8 (/IGI) O42606 (/IGI) Q8JH35 (/IGI) Q9DE43 (/IGI)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
4 P46581 (/IMP) P70447 (/IMP) P70447 (/IMP) P70660 (/IMP)
Positive regulation of synaptic plasticity GO:0031915
A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
4 Q15784 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q63689 (/ISS)
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
4 O09105 (/IMP) O09105 (/IMP) Q62414 (/IMP) Q62414 (/IMP)
Positive regulation of neurogenesis GO:0050769
Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
4 F1QWM8 (/IMP) Q6NYU3 (/IMP) Q8JH35 (/IMP) Q9DE43 (/IMP)
Positive regulation of calcium-mediated signaling GO:0050850
Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
4 Q15784 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q63689 (/ISS)
Cellular response to electrical stimulus GO:0071257
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
4 Q15784 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q63689 (/ISS)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
4 Q15784 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q63689 (/ISS)
Olfactory placode development GO:0071698
The progression of the olfactory placode over time from its initial formation until its mature state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity.
4 F1QWM8 (/IGI) O42606 (/IGI) Q8JH35 (/IGI) Q9DE43 (/IGI)
Positive regulation of synapse maturation GO:0090129
Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
4 Q15784 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q63689 (/ISS)
Negative regulation of synapse maturation GO:2000297
Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation.
4 Q15784 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q63689 (/ISS)
Neural plate morphogenesis GO:0001839
The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.
3 F1QWM8 (/IMP) Q8JH35 (/IMP) Q9DE43 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
3 O16867 (/IMP) P70447 (/IMP) P70447 (/IMP)
Dentate gyrus development GO:0021542
The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus.
3 P48986 (/IGI) P48986 (/IGI) Q60867 (/IGI)
Neurogenesis GO:0022008
Generation of cells within the nervous system.
3 P70447 (/IDA) P70447 (/IDA) P70660 (/IDA)
Amacrine cell differentiation GO:0035881
The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons.
3 O09105 (/IDA) O09105 (/IDA) Q60867 (/IDA)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
3 O09105 (/IGI) O09105 (/IGI) Q60867 (/IGI)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
3 O09105 (/IDA) O09105 (/IDA) Q60867 (/IDA)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
3 P70661 (/ISO) P70661 (/ISO) Q60867 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P70447 (/IGI) P70447 (/IGI) Q60867 (/IGI)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P70447 (/IMP) P70447 (/IMP) Q60867 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P70661 (/ISO) P70661 (/ISO) Q60867 (/ISO)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P70661 (/ISO) P70661 (/ISO)
Behavioral fear response GO:0001662
An acute behavioral change resulting from a perceived external threat.
2 Q62414 (/IMP) Q62414 (/IMP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
2 O09105 (/IGI) O09105 (/IGI)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 P70661 (/ISO) P70661 (/ISO)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 O09105 (/IGI) O09105 (/IGI)
Nitric oxide mediated signal transduction GO:0007263
Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.
2 Q13562 (/IDA) Q13562 (/IDA)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
2 P70661 (/IMP) P70661 (/IMP)
Thorax and anterior abdomen determination GO:0007356
Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product.
2 Q92886 (/IGI) Q92886 (/IGI)
Neuroblast proliferation GO:0007405
The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.
2 O09105 (/IGI) O09105 (/IGI)
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
2 O42606 (/IMP) P46581 (/IMP)
Associative learning GO:0008306
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
2 Q62414 (/IMP) Q62414 (/IMP)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
2 Q13562 (/IMP) Q13562 (/IMP)
Glial cell differentiation GO:0010001
The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.
2 O09105 (/IGI) O09105 (/IGI)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
2 Q62414 (/IDA) Q62414 (/IDA)
Trigeminal nerve development GO:0021559
The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
2 Q92886 (/IGI) Q92886 (/IGI)
Vestibulocochlear nerve formation GO:0021650
The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.
2 Q92886 (/IGI) Q92886 (/IGI)
Cerebellar cortex development GO:0021695
The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
2 Q62414 (/IMP) Q62414 (/IMP)
Central nervous system neuron development GO:0021954
The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
2 P70447 (/IGI) P70447 (/IGI)
Central nervous system neuron development GO:0021954
The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
2 P70447 (/IMP) P70447 (/IMP)
Neurogenesis GO:0022008
Generation of cells within the nervous system.
2 Q13562 (/TAS) Q13562 (/TAS)
Insulin secretion GO:0030073
The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
2 Q13562 (/IDA) Q13562 (/IDA)
Peristalsis GO:0030432
A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards.
2 Q92886 (/IGI) Q92886 (/IGI)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
2 P70661 (/IMP) P70661 (/IMP)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
2 P70447 (/IMP) P70447 (/IMP)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
2 O42202 (/IMP) Q60867 (/IMP)
Auditory behavior GO:0031223
The behavior of an organism in response to a sound.
2 Q92886 (/IGI) Q92886 (/IGI)
Positive regulation of synaptic plasticity GO:0031915
A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
2 Q62414 (/IDA) Q62414 (/IDA)
Genitalia morphogenesis GO:0035112
The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal.
2 Q92886 (/IGI) Q92886 (/IGI)
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
2 Q92886 (/IGI) Q92886 (/IGI)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
2 Q13562 (/ISS) Q13562 (/ISS)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
2 O09105 (/ISO) O09105 (/ISO)
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
2 P70660 (/IGI) Q60867 (/IGI)
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
2 P70447 (/IMP) P70447 (/IMP)
Embryonic organ morphogenesis GO:0048562
Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
2 Q13562 (/ISS) Q13562 (/ISS)
Regulation of muscle organ development GO:0048634
Any process that modulates the frequency, rate or extent of muscle development.
2 Q92886 (/IGI) Q92886 (/IGI)
Genitalia development GO:0048806
The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure.
2 Q92886 (/IGI) Q92886 (/IGI)
Regulation of dendrite morphogenesis GO:0048814
Any process that modulates the frequency, rate or extent of dendrite morphogenesis.
2 P70661 (/IGI) P70661 (/IGI)
Inner ear development GO:0048839
The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.
2 Q92886 (/IGI) Q92886 (/IGI)
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
2 Q13562 (/IC) Q13562 (/IC)
Positive regulation of calcium-mediated signaling GO:0050850
Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
2 Q62414 (/IDA) Q62414 (/IDA)
Neuromuscular process controlling balance GO:0050885
Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.
2 Q92886 (/IGI) Q92886 (/IGI)
Transdifferentiation GO:0060290
The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.
2 P70661 (/IDA) P70661 (/IDA)
Cellular response to electrical stimulus GO:0071257
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
2 Q62414 (/IDA) Q62414 (/IDA)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
2 Q62414 (/IDA) Q62414 (/IDA)
Mastication GO:0071626
The process of biting and mashing food with the teeth prior to swallowing.
2 Q92886 (/IGI) Q92886 (/IGI)
Cochlea development GO:0090102
The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound.
2 Q92886 (/IGI) Q92886 (/IGI)
Cochlea morphogenesis GO:0090103
The process in which the cochlea is generated and organized.
2 Q92886 (/IGI) Q92886 (/IGI)
Positive regulation of synapse maturation GO:0090129
Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
2 Q62414 (/IMP) Q62414 (/IMP)
Craniofacial suture morphogenesis GO:0097094
The process in which any suture between cranial and/or facial bones is generated and organized.
2 Q92886 (/IGI) Q92886 (/IGI)
Learned vocalization behavior GO:0098583
A vocalization behavior that is the result of learning.
2 Q92886 (/IGI) Q92886 (/IGI)
Negative regulation of relaxation of muscle GO:1901078
Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of muscle.
2 Q92886 (/IGI) Q92886 (/IGI)
Negative regulation of saliva secretion GO:1905747
Any process that stops, prevents or reduces the frequency, rate or extent of saliva secretion.
2 Q92886 (/IGI) Q92886 (/IGI)
Hard palate morphogenesis GO:1905748
The developmental process by which a hard palate is generated and organized.
2 Q92886 (/IGI) Q92886 (/IGI)
Negative regulation of synapse maturation GO:2000297
Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation.
2 Q62414 (/IDA) Q62414 (/IDA)
Negative regulation of type B pancreatic cell apoptotic process GO:2000675
Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process.
2 Q13562 (/ISS) Q13562 (/ISS)
Positive regulation of transcription regulatory region DNA binding GO:2000679
Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding.
2 Q13562 (/IDA) Q13562 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9Y4Z2 (/IDA)
Pancreatic A cell fate commitment GO:0003326
The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
1 Q60867 (/IGI)
Pancreatic PP cell fate commitment GO:0003329
The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.
1 Q60867 (/IGI)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 O08718 (/IDA)
Nucleocytoplasmic transport GO:0006913
The directed movement of molecules between the nucleus and the cytoplasm.
1 Q64289 (/IDA)
Nucleocytoplasmic transport GO:0006913
The directed movement of molecules between the nucleus and the cytoplasm.
1 Q60867 (/ISO)
Nitric oxide mediated signal transduction GO:0007263
Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.
1 Q60867 (/ISO)
Thorax and anterior abdomen determination GO:0007356
Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product.
1 P70660 (/ISO)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 O42606 (/IEP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 O42606 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 P70595 (/NAS)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
1 Q9Y4Z2 (/TAS)
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
1 O42606 (/IMP)
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
1 Q9Y4Z2 (/TAS)
Sensory organ development GO:0007423
The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.
1 O16867 (/TAS)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 Q60867 (/ISO)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
1 Q60867 (/IMP)
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
1 O16867 (/IMP)
Spinal cord development GO:0021510
The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.
1 O08718 (/IEP)
Dorsal spinal cord development GO:0021516
The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input.
1 O42606 (/IMP)
Dentate gyrus development GO:0021542
The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus.
1 Q60867 (/IMP)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
1 Q64289 (/IEP)
Cerebellum development GO:0021549
The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.
1 Q60867 (/IMP)
Trigeminal nerve development GO:0021559
The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.
1 P70660 (/ISO)
Hindbrain morphogenesis GO:0021575
The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
1 O42606 (/IGI)
Vestibulocochlear nerve formation GO:0021650
The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.
1 P70660 (/ISO)
Olfactory bulb development GO:0021772
The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex.
1 O42606 (/IMP)
Forebrain neuron development GO:0021884
The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell.
1 O42606 (/IDA)
Forebrain neuron development GO:0021884
The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell.
1 O42606 (/IMP)
Signal transduction involved in regulation of gene expression GO:0023019
Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.
1 Q60867 (/IDA)
Insulin secretion GO:0030073
The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
1 Q60867 (/ISO)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 P70660 (/IDA)
Peristalsis GO:0030432
A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards.
1 P70660 (/ISO)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
1 O08718 (/IEP)
Hindbrain development GO:0030902
The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).
1 O08718 (/IEP)
Hindbrain development GO:0030902
The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).
1 Q60867 (/IMP)
Regeneration GO:0031099
The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass).
1 O42202 (/IMP)
Axon regeneration GO:0031103
The regrowth of axons following their loss or damage.
1 O42606 (/IMP)
Auditory behavior GO:0031223
The behavior of an organism in response to a sound.
1 P70660 (/ISO)
Positive regulation of exit from mitosis GO:0031536
Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).
1 P70660 (/IMP)
Genitalia morphogenesis GO:0035112
The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal.
1 P70660 (/ISO)
Enteroendocrine cell differentiation GO:0035883
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.
1 Q60867 (/IMP)
Compound eye photoreceptor development GO:0042051
The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure.
1 O42202 (/IMP)
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
1 P70660 (/IMP)
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
1 P70660 (/ISO)
Positive regulation of eye photoreceptor cell development GO:0042479
Any process that activates or increases the frequency, rate or extent of eye photoreceptor development.
1 P79765 (/IDA)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q64289 (/IEP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
1 Q60867 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q60867 (/IDA)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
1 O08718 (/IEP)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
1 D4A7M5 (/IMP)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
1 O08718 (/IMP)
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
1 O42202 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q60867 (/IDA)
Negative regulation of receptor signaling pathway via JAK-STAT GO:0046426
Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT.
1 Q60867 (/IDA)
Embryonic organ morphogenesis GO:0048562
Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
1 Q60867 (/IMP)
Regulation of muscle organ development GO:0048634
Any process that modulates the frequency, rate or extent of muscle development.
1 P70660 (/ISO)
Generation of neurons GO:0048699
The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.
1 O42606 (/IMP)
Genitalia development GO:0048806
The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure.
1 P70660 (/ISO)
Inner ear development GO:0048839
The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.
1 Q60867 (/IMP)
Inner ear development GO:0048839
The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.
1 P70660 (/ISO)
Negative regulation of axon extension involved in axon guidance GO:0048843
Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance.
1 O16867 (/IMP)
Neuromast development GO:0048884
The process whose specific outcome is the progression of the neuromast over time, from its formation to the mature structure. The neuromast is the sensory organ of the lateral line and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromasts are located superficially on the epithelium or in lateral line canals.
1 O42606 (/IMP)
Anterior lateral line nerve development GO:0048909
The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.
1 O42606 (/IMP)
Posterior lateral line nerve development GO:0048918
The process whose specific outcome is the progression of the posterior lateral line nerve over time, from its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.
1 O42606 (/IMP)
Posterior lateral line neuromast hair cell differentiation GO:0048923
The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons.
1 O42202 (/IMP)
Peripheral nervous system neuron development GO:0048935
The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
1 O42606 (/IMP)
Negative regulation of neurogenesis GO:0050768
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
1 O42606 (/IMP)
Neuromuscular process controlling balance GO:0050885
Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.
1 P70660 (/ISO)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q60867 (/ISO)
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
1 D4A7M5 (/IEP)
Inner ear receptor cell development GO:0060119
The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
1 O42202 (/IMP)
Transdifferentiation GO:0060290
The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.
1 Q9Y4Z2 (/ISS)
Regulation of intestinal epithelial structure maintenance GO:0060730
Any process that modulates the rate, frequency, or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.
1 Q60867 (/IDA)
Regulation of cell cycle arrest GO:0071156
Any process that modulates the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.
1 Q60867 (/IMP)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 Q64289 (/IDA)
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 Q60867 (/ISO)
Mastication GO:0071626
The process of biting and mashing food with the teeth prior to swallowing.
1 P70660 (/ISO)
Olfactory placode development GO:0071698
The progression of the olfactory placode over time from its initial formation until its mature state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity.
1 O42606 (/IMP)
Cochlea development GO:0090102
The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound.
1 P70660 (/ISO)
Cochlea morphogenesis GO:0090103
The process in which the cochlea is generated and organized.
1 P70660 (/ISO)
Craniofacial suture morphogenesis GO:0097094
The process in which any suture between cranial and/or facial bones is generated and organized.
1 P70660 (/ISO)
Learned vocalization behavior GO:0098583
A vocalization behavior that is the result of learning.
1 P70660 (/ISO)
Negative regulation of relaxation of muscle GO:1901078
Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of muscle.
1 P70660 (/ISO)
Negative regulation of saliva secretion GO:1905747
Any process that stops, prevents or reduces the frequency, rate or extent of saliva secretion.
1 P70660 (/ISO)
Hard palate morphogenesis GO:1905748
The developmental process by which a hard palate is generated and organized.
1 P70660 (/ISO)
Negative regulation of type B pancreatic cell apoptotic process GO:2000675
Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process.
1 Q60867 (/IMP)
Positive regulation of transcription regulatory region DNA binding GO:2000679
Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding.
1 Q60867 (/ISO)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
14 O08718 (/IDA) O16867 (/IDA) P46581 (/IDA) P70447 (/IDA) P70447 (/IDA) P70661 (/IDA) P70661 (/IDA) Q13562 (/IDA) Q13562 (/IDA) Q60867 (/IDA)
(4 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 Q15784 (/ISS) Q15784 (/ISS) Q15784 (/ISS) Q63689 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q13562 (/IC) Q13562 (/IC) Q60867 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P70661 (/ISO) P70661 (/ISO) Q60867 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 Q13562 (/TAS) Q13562 (/TAS) Q60867 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 O08718 (/IDA) Q60867 (/IDA) Q64289 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P70661 (/ISO) P70661 (/ISO) Q60867 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P70661 (/TAS) P70661 (/TAS)
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
2 Q13562 (/IDA) Q13562 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P70660 (/IDA)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
1 P70660 (/IDA)
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
1 Q60867 (/ISO)
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