The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Helix-loop-helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 55: DNA-binding protein inhibitor ID-2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
22 P41136 (/IPI) P41136 (/IPI) P41137 (/IPI) Q02363 (/IPI) Q02363 (/IPI) Q02363 (/IPI) Q02363 (/IPI) Q02363 (/IPI) Q02363 (/IPI) Q02363 (/IPI)
(12 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
19 Q02363 (/ISM) Q02363 (/ISM) Q02363 (/ISM) Q02363 (/ISM) Q02363 (/ISM) Q02363 (/ISM) Q02363 (/ISM) Q02363 (/ISM) Q02363 (/ISM) Q02363 (/ISM)
(9 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
19 Q02363 (/NAS) Q02363 (/NAS) Q02363 (/NAS) Q02363 (/NAS) Q02363 (/NAS) Q02363 (/NAS) Q02363 (/NAS) Q02363 (/NAS) Q02363 (/NAS) Q02363 (/NAS)
(9 more)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
19 Q02363 (/IPI) Q02363 (/IPI) Q02363 (/IPI) Q02363 (/IPI) Q02363 (/IPI) Q02363 (/IPI) Q02363 (/IPI) Q02363 (/IPI) Q02363 (/IPI) Q02363 (/IPI)
(9 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
3 O73933 (/NAS) O73933 (/NAS) O73933 (/NAS)
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
3 O73933 (/NAS) O73933 (/NAS) O73933 (/NAS)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
2 P41136 (/ISO) P41136 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 P41137 (/IC)

There are 110 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Mammary gland epithelial cell proliferation GO:0033598
The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Entrainment of circadian clock by photoperiod GO:0043153
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Locomotor rhythm GO:0045475
The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Positive regulation of blood pressure GO:0045777
Any process in which the force of blood traveling through the circulatory system is increased.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Embryonic digestive tract morphogenesis GO:0048557
The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Neuron fate commitment GO:0048663
The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Mammary gland alveolus development GO:0060749
The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Epithelial cell differentiation involved in mammary gland alveolus development GO:0061030
The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Endodermal digestive tract morphogenesis GO:0061031
The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Positive regulation of cell cycle arrest GO:0071158
Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Cellular senescence GO:0090398
A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Negative regulation of neural precursor cell proliferation GO:2000178
Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
45 P41137 (/ISS) Q2VIU1 (/ISS) Q2VIU1 (/ISS) Q3ZC46 (/ISS) Q3ZC46 (/ISS) Q3ZC46 (/ISS) Q3ZC46 (/ISS) Q4R5J7 (/ISS) Q4R5J7 (/ISS) Q4R5J7 (/ISS)
(35 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
21 P41136 (/IDA) P41136 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA)
(11 more)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
19 Q02363 (/TAS) Q02363 (/TAS) Q02363 (/TAS) Q02363 (/TAS) Q02363 (/TAS) Q02363 (/TAS) Q02363 (/TAS) Q02363 (/TAS) Q02363 (/TAS) Q02363 (/TAS)
(9 more)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
19 Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA)
(9 more)
Positive regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0071931
Any process that activates or increases transcription as part of the G1/S transition of the mitotic cell cycle.
19 Q02363 (/IC) Q02363 (/IC) Q02363 (/IC) Q02363 (/IC) Q02363 (/IC) Q02363 (/IC) Q02363 (/IC) Q02363 (/IC) Q02363 (/IC) Q02363 (/IC)
(9 more)
Regulation of G1/S transition of mitotic cell cycle GO:2000045
Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
19 Q02363 (/IMP) Q02363 (/IMP) Q02363 (/IMP) Q02363 (/IMP) Q02363 (/IMP) Q02363 (/IMP) Q02363 (/IMP) Q02363 (/IMP) Q02363 (/IMP) Q02363 (/IMP)
(9 more)
Neuron fate commitment GO:0048663
The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.
5 O73933 (/IMP) O73933 (/IMP) O73933 (/IMP) P41136 (/IMP) P41136 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 P41136 (/IDA) P41136 (/IDA) P41137 (/IDA)
Secondary heart field specification GO:0003139
The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).
3 O73933 (/IEP) O73933 (/IEP) O73933 (/IEP)
Cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253
The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract.
3 O73933 (/IEP) O73933 (/IEP) O73933 (/IEP)
Chondrocyte hypertrophy GO:0003415
The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time.
3 O73933 (/NAS) O73933 (/NAS) O73933 (/NAS)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
3 O73933 (/IMP) O73933 (/IMP) O73933 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 O73933 (/IEP) O73933 (/IEP) O73933 (/IEP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 P41136 (/IMP) P41136 (/IMP) P41137 (/IMP)
Neural crest formation GO:0014029
The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.
3 O73933 (/IEP) O73933 (/IEP) O73933 (/IEP)
Neural crest cell fate commitment GO:0014034
The process in which a cell becomes committed to become a neural crest cell.
3 O73933 (/IMP) O73933 (/IMP) O73933 (/IMP)
Limb morphogenesis GO:0035108
The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping.
3 O73933 (/NAS) O73933 (/NAS) O73933 (/NAS)
Chondrocyte proliferation GO:0035988
The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.
3 O73933 (/NAS) O73933 (/NAS) O73933 (/NAS)
Embryonic digit morphogenesis GO:0042733
The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.
3 O73933 (/ISS) O73933 (/ISS) O73933 (/ISS)
Negative regulation of DNA binding GO:0043392
Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
3 O73933 (/NAS) O73933 (/NAS) O73933 (/NAS)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
3 O73933 (/IEP) O73933 (/IEP) O73933 (/IEP)
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
3 O73933 (/NAS) O73933 (/NAS) O73933 (/NAS)
Muscle cell development GO:0055001
The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.
3 O73933 (/NAS) O73933 (/NAS) O73933 (/NAS)
Limb development GO:0060173
The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.
3 O73933 (/ISS) O73933 (/ISS) O73933 (/ISS)
Innervation GO:0060384
The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue.
3 O73933 (/IEP) O73933 (/IEP) O73933 (/IEP)
Cardiac neuron development GO:0060959
The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state.
3 O73933 (/IEP) O73933 (/IEP) O73933 (/IEP)
Cellular response to BMP stimulus GO:0071773
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus.
3 O73933 (/NAS) O73933 (/NAS) O73933 (/NAS)
Positive regulation of neural crest formation GO:0090300
Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.
3 O73933 (/IEP) O73933 (/IEP) O73933 (/IEP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P41136 (/IGI) P41136 (/IGI)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P41136 (/ISO) P41136 (/ISO)
Metanephros development GO:0001656
The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.
2 P41136 (/IMP) P41136 (/IMP)
Natural killer cell differentiation GO:0001779
The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
2 P41136 (/IGI) P41136 (/IGI)
Natural killer cell differentiation GO:0001779
The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
2 P41136 (/IMP) P41136 (/IMP)
Thigmotaxis GO:0001966
The directed movement of a motile cell or organism in response to touch.
2 P41136 (/IMP) P41136 (/IMP)
Leukocyte differentiation GO:0002521
The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
2 P41136 (/IMP) P41136 (/IMP)
Membranous septum morphogenesis GO:0003149
The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.
2 P41136 (/IMP) P41136 (/IMP)
Bundle of His development GO:0003166
The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers.
2 P41136 (/IMP) P41136 (/IMP)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
2 P41136 (/IGI) P41136 (/IGI)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
2 P41136 (/IEP) P41136 (/IEP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 P41136 (/ISO) P41136 (/ISO)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
2 P41136 (/IMP) P41136 (/IMP)
Entrainment of circadian clock GO:0009649
The synchronization of a circadian rhythm to environmental time cues such as light.
2 P41136 (/IMP) P41136 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P41136 (/IMP) P41136 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P41136 (/ISO) P41136 (/ISO)
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
2 P41136 (/IMP) P41136 (/IMP)
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
2 P41136 (/IMP) P41136 (/IMP)
Olfactory bulb development GO:0021772
The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex.
2 P41136 (/IMP) P41136 (/IMP)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
2 P41136 (/IMP) P41136 (/IMP)
Mammary gland epithelial cell proliferation GO:0033598
The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
2 P41136 (/IMP) P41136 (/IMP)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
2 P41136 (/IMP) P41136 (/IMP)
Entrainment of circadian clock by photoperiod GO:0043153
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
2 P41136 (/IMP) P41136 (/IMP)
Enucleate erythrocyte differentiation GO:0043353
The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus.
2 P41136 (/IGI) P41136 (/IGI)
Negative regulation of DNA binding GO:0043392
Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
2 P41136 (/IDA) P41136 (/IDA)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
2 P41136 (/ISO) P41136 (/ISO)
Locomotor rhythm GO:0045475
The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
2 P41136 (/IMP) P41136 (/IMP)
Negative regulation of B cell differentiation GO:0045578
Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation.
2 P41136 (/IMP) P41136 (/IMP)
Positive regulation of fat cell differentiation GO:0045600
Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
2 P41136 (/IMP) P41136 (/IMP)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
2 P41136 (/IMP) P41136 (/IMP)
Positive regulation of macrophage differentiation GO:0045651
Any process that activates or increases the frequency, rate or extent of macrophage differentiation.
2 P41136 (/IGI) P41136 (/IGI)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
2 P41136 (/IMP) P41136 (/IMP)
Negative regulation of osteoblast differentiation GO:0045668
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.
2 P41136 (/IGI) P41136 (/IGI)
Positive regulation of blood pressure GO:0045777
Any process in which the force of blood traveling through the circulatory system is increased.
2 P41136 (/IMP) P41136 (/IMP)
Positive regulation of cell cycle GO:0045787
Any process that activates or increases the rate or extent of progression through the cell cycle.
2 P41136 (/ISO) P41136 (/ISO)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P41136 (/IMP) P41136 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P41136 (/ISO) P41136 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P41136 (/IMP) P41136 (/IMP)
Cell development GO:0048468
The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
2 P41136 (/IGI) P41136 (/IGI)
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
2 P41136 (/IMP) P41136 (/IMP)
Lymph node development GO:0048535
The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes.
2 P41136 (/TAS) P41136 (/TAS)
Peyer's patch development GO:0048541
The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes.
2 P41136 (/IGI) P41136 (/IGI)
Embryonic digestive tract morphogenesis GO:0048557
The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.
2 P41136 (/IDA) P41136 (/IDA)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
2 P41136 (/IMP) P41136 (/IMP)
Cell morphogenesis involved in neuron differentiation GO:0048667
The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.
2 P41136 (/IMP) P41136 (/IMP)
Positive regulation of astrocyte differentiation GO:0048711
Any process that activates or increases the frequency, rate or extent of astrocyte differentiation.
2 P41136 (/IMP) P41136 (/IMP)
Negative regulation of oligodendrocyte differentiation GO:0048715
Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.
2 P41136 (/IMP) P41136 (/IMP)
Adipose tissue development GO:0060612
The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.
2 P41136 (/IMP) P41136 (/IMP)
Mammary gland alveolus development GO:0060749
The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland.
2 P41136 (/IMP) P41136 (/IMP)
Epithelial cell differentiation involved in mammary gland alveolus development GO:0061030
The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus.
2 P41136 (/IMP) P41136 (/IMP)
Endodermal digestive tract morphogenesis GO:0061031
The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm.
2 P41136 (/IEP) P41136 (/IEP)
Positive regulation of cell cycle arrest GO:0071158
Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.
2 P41136 (/IMP) P41136 (/IMP)
Cellular response to lithium ion GO:0071285
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
2 P41136 (/IDA) P41136 (/IDA)
Cellular senescence GO:0090398
A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
2 P41136 (/IMP) P41136 (/IMP)
Regulation of G1/S transition of mitotic cell cycle GO:2000045
Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
2 P41136 (/ISO) P41136 (/ISO)
Negative regulation of neural precursor cell proliferation GO:2000178
Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.
2 P41136 (/IMP) P41136 (/IMP)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 Q3LSV1 (/TAS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P41137 (/IDA)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 P41137 (/IEP)
Embryonic digit morphogenesis GO:0042733
The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.
1 Q3LSV1 (/IEP)
Positive regulation of cell cycle GO:0045787
Any process that activates or increases the rate or extent of progression through the cell cycle.
1 P41137 (/IDA)
Limb development GO:0060173
The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.
1 Q3LSV1 (/IEP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
64 P41137 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS) Q02363 (/ISS)
(54 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
44 Q2VIU1 (/ISS) Q2VIU1 (/ISS) Q3ZC46 (/ISS) Q3ZC46 (/ISS) Q3ZC46 (/ISS) Q3ZC46 (/ISS) Q4R5J7 (/ISS) Q4R5J7 (/ISS) Q4R5J7 (/ISS) Q4R5J7 (/ISS)
(34 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
25 O73933 (/IDA) O73933 (/IDA) O73933 (/IDA) P41136 (/IDA) P41136 (/IDA) P41137 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA)
(15 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
22 P41136 (/IDA) P41136 (/IDA) P41137 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA)
(12 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
20 P41137 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA) Q02363 (/IDA)
(10 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
19 Q02363 (/IC) Q02363 (/IC) Q02363 (/IC) Q02363 (/IC) Q02363 (/IC) Q02363 (/IC) Q02363 (/IC) Q02363 (/IC) Q02363 (/IC) Q02363 (/IC)
(9 more)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
2 P41136 (/ISO) P41136 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P41136 (/ISO) P41136 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P41136 (/ISO) P41136 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P41136 (/ISO) P41136 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 P41136 (/IDA) P41136 (/IDA)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
1 P41137 (/IDA)