The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Helix-loop-helix DNA-binding domain
".
FunFam 5: Myogenic factor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 45 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
|
26 |
P13904 (/ISS)
P15172 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P16075 (/ISS)
P16076 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P20428 (/ISS)
(16 more) |
|
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
|
26 |
P13904 (/ISS)
P15172 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P16075 (/ISS)
P16076 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P20428 (/ISS)
(16 more) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
20 |
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P20428 (/ISS)
P29331 (/ISS)
P29331 (/ISS)
P34060 (/ISS)
P49811 (/ISS)
(10 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
19 |
P13349 (/ISA)
P13349 (/ISA)
P15172 (/ISA)
P15173 (/ISA)
P15173 (/ISA)
P15173 (/ISA)
P23409 (/ISA)
P23409 (/ISA)
P23409 (/ISA)
P23409 (/ISA)
(9 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
19 |
P13349 (/ISM)
P13349 (/ISM)
P15172 (/ISM)
P15173 (/ISM)
P15173 (/ISM)
P15173 (/ISM)
P23409 (/ISM)
P23409 (/ISM)
P23409 (/ISM)
P23409 (/ISM)
(9 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
19 |
P13349 (/NAS)
P13349 (/NAS)
P15172 (/NAS)
P15173 (/NAS)
P15173 (/NAS)
P15173 (/NAS)
P23409 (/NAS)
P23409 (/NAS)
P23409 (/NAS)
P23409 (/NAS)
(9 more) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
19 |
P13349 (/ISS)
P13349 (/ISS)
P15172 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P23409 (/ISS)
P23409 (/ISS)
P23409 (/ISS)
P23409 (/ISS)
(9 more) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
17 |
P15173 (/TAS)
P15173 (/TAS)
P15173 (/TAS)
P22816 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
(7 more) |
|
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
|
15 |
P13904 (/ISS)
P15172 (/ISS)
P16075 (/ISS)
P16076 (/ISS)
P21572 (/ISS)
P29331 (/ISS)
P29331 (/ISS)
P49811 (/ISS)
P49811 (/ISS)
Q02346 (/ISS)
(5 more) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
10 | P10085 (/IDA) P12979 (/IDA) P15172 (/IDA) P15173 (/IDA) P15173 (/IDA) P15173 (/IDA) P15375 (/IDA) P15375 (/IDA) P24699 (/IDA) P24699 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
9 | P10085 (/TAS) P12979 (/TAS) P13349 (/TAS) P13349 (/TAS) P15172 (/TAS) P15375 (/TAS) P15375 (/TAS) P24699 (/TAS) P24699 (/TAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
9 | P10085 (/IPI) P12979 (/IPI) P13349 (/IPI) P13349 (/IPI) P15172 (/IPI) P15173 (/IPI) P15173 (/IPI) P15173 (/IPI) Q90477 (/IPI) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
7 | P15172 (/ISS) P29331 (/ISS) P29331 (/ISS) P49811 (/ISS) P49811 (/ISS) Q02346 (/ISS) Q7YS82 (/ISS) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
7 | P29331 (/ISS) P29331 (/ISS) P49811 (/ISS) P49811 (/ISS) Q0VBX9 (/ISS) Q0VBX9 (/ISS) Q7YS82 (/ISS) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
7 | P10085 (/IDA) P12979 (/IDA) P15173 (/IDA) P15173 (/IDA) P15173 (/IDA) P24699 (/IDA) P24699 (/IDA) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
7 | P16075 (/IDA) P17920 (/IDA) P17920 (/IDA) Q01795 (/IDA) Q01795 (/IDA) Q01795 (/IDA) Q08856 (/IDA) |
|
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
|
6 | P12979 (/IDA) P15172 (/IDA) P15173 (/IDA) P15173 (/IDA) P15173 (/IDA) P22980 (/IDA) |
|
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
|
6 | P10085 (/IDA) P12979 (/IDA) P16075 (/IDA) P17920 (/IDA) P17920 (/IDA) Q02346 (/IDA) |
|
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
|
3 | P15173 (/ISS) P15173 (/ISS) P15173 (/ISS) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
3 | P10085 (/IDA) P12979 (/IDA) P20428 (/IDA) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
3 | P15173 (/TAS) P15173 (/TAS) P15173 (/TAS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
3 | P10085 (/IDA) P12979 (/IDA) P22980 (/IDA) |
|
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
|
2 | P10085 (/ISO) P12979 (/ISO) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P10085 (/IC) P12979 (/IC) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | P10085 (/ISO) P12979 (/ISO) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | P10085 (/IDA) P12979 (/IDA) |
|
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
|
2 | P10085 (/IDA) P12979 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | P12979 (/ISO) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | P22980 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | P22980 (/ISS) |
|
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | P12979 (/IDA) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | P10085 (/IMP) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | P10085 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | P10085 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | P15172 (/TAS) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | P10085 (/IPI) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | P10085 (/IPI) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | P10085 (/IPI) |
|
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
|
1 | P15172 (/IPI) |
|
Nuclear hormone receptor binding GO:0035257
Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.
|
1 | P10085 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P22980 (/IPI) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | P12979 (/ISO) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | P10085 (/IPI) |
|
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
|
1 | P10085 (/ISO) |
|
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
|
1 | P10085 (/IDA) |
There are 148 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
36 |
P13904 (/ISS)
P15172 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P16076 (/ISS)
P20428 (/ISS)
P21572 (/ISS)
P23409 (/ISS)
P23409 (/ISS)
(26 more) |
|
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
26 |
P13904 (/ISS)
P15172 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P16075 (/ISS)
P16076 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P20428 (/ISS)
(16 more) |
|
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
|
23 |
P10085 (/TAS)
P12979 (/TAS)
P13349 (/TAS)
P13349 (/TAS)
P15172 (/TAS)
P15173 (/TAS)
P15173 (/TAS)
P15173 (/TAS)
P15375 (/TAS)
P15375 (/TAS)
(13 more) |
|
Muscle cell fate commitment GO:0042693
The process in which the cellular identity of muscle cells is acquired and determined.
|
19 |
P13349 (/ISS)
P13349 (/ISS)
P15172 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P23409 (/ISS)
P23409 (/ISS)
P23409 (/ISS)
P23409 (/ISS)
(9 more) |
|
Positive regulation of muscle cell differentiation GO:0051149
Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.
|
19 |
P13349 (/TAS)
P13349 (/TAS)
P15172 (/TAS)
P15173 (/TAS)
P15173 (/TAS)
P15173 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
(9 more) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
16 |
P13349 (/TAS)
P13349 (/TAS)
P15172 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
(6 more) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
16 |
P10085 (/IDA)
P12979 (/IDA)
P15172 (/IDA)
P15173 (/IDA)
P15173 (/IDA)
P15173 (/IDA)
P16075 (/IDA)
P17920 (/IDA)
P17920 (/IDA)
P20428 (/IDA)
(6 more) |
|
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
|
15 |
A0A0R4IN45 (/IGI)
B0S6I5 (/IGI)
P10085 (/IGI)
P15375 (/IGI)
P15375 (/IGI)
P24699 (/IGI)
P24699 (/IGI)
Q5CZP8 (/IGI)
Q5TZ22 (/IGI)
Q66L62 (/IGI)
(5 more) |
|
Positive regulation of snRNA transcription by RNA polymerase II GO:1905382
Any process that activates or increases the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II.
|
15 |
P13904 (/ISS)
P15172 (/ISS)
P16075 (/ISS)
P16076 (/ISS)
P21572 (/ISS)
P29331 (/ISS)
P29331 (/ISS)
P49811 (/ISS)
P49811 (/ISS)
Q02346 (/ISS)
(5 more) |
|
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
|
14 |
A0A0R4IN45 (/IGI)
B0S6I5 (/IGI)
P10085 (/IGI)
P12979 (/IGI)
P24699 (/IGI)
P24699 (/IGI)
Q5CZP8 (/IGI)
Q5TZ22 (/IGI)
Q66L62 (/IGI)
Q90477 (/IGI)
(4 more) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
13 |
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P20428 (/ISS)
P34060 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
(3 more) |
|
Positive regulation of myotube differentiation GO:0010831
Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
|
13 |
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P20428 (/ISS)
P34060 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
(3 more) |
|
Positive regulation of muscle atrophy GO:0014737
Any process that activates or increases the frequency, rate or extent of muscle atrophy.
|
13 |
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P20428 (/ISS)
P34060 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
(3 more) |
|
Regulation of skeletal muscle satellite cell proliferation GO:0014842
Any process that modulates the frequency, rate or extent of skeletal muscle satellite cell proliferation.
|
13 |
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P20428 (/ISS)
P34060 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
(3 more) |
|
Response to muscle activity involved in regulation of muscle adaptation GO:0014873
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation.
|
13 |
P12979 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P34060 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
(3 more) |
|
Response to electrical stimulus involved in regulation of muscle adaptation GO:0014878
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation.
|
13 |
P12979 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P34060 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
(3 more) |
|
Striated muscle atrophy GO:0014891
A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse.
|
13 |
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P20428 (/ISS)
P34060 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
(3 more) |
|
Response to denervation involved in regulation of muscle adaptation GO:0014894
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation.
|
13 |
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P20428 (/ISS)
P34060 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
(3 more) |
|
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
|
13 |
P13904 (/ISS)
P15172 (/ISS)
P16075 (/ISS)
P16076 (/ISS)
P21572 (/ISS)
P29331 (/ISS)
P29331 (/ISS)
P49811 (/ISS)
P49811 (/ISS)
Q02346 (/ISS)
(3 more) |
|
Histone H4 acetylation GO:0043967
The modification of histone H4 by the addition of an acetyl group.
|
13 |
P13904 (/ISS)
P15172 (/ISS)
P16075 (/ISS)
P16076 (/ISS)
P21572 (/ISS)
P29331 (/ISS)
P29331 (/ISS)
P49811 (/ISS)
P49811 (/ISS)
Q02346 (/ISS)
(3 more) |
|
Positive regulation of myoblast differentiation GO:0045663
Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
13 |
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P20428 (/ISS)
P34060 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
(3 more) |
|
Positive regulation of skeletal muscle fiber development GO:0048743
Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
|
13 |
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P20428 (/ISS)
P34060 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
(3 more) |
|
Positive regulation of cell cycle arrest GO:0071158
Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.
|
13 |
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P20428 (/ISS)
P34060 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
(3 more) |
|
Regulation of myoblast fusion GO:1901739
Any process that modulates the frequency, rate or extent of myoblast fusion.
|
13 |
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P20428 (/ISS)
P34060 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
(3 more) |
|
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
|
12 |
P10085 (/IMP)
P15375 (/IMP)
P15375 (/IMP)
P24699 (/IMP)
P24699 (/IMP)
Q5CZP8 (/IMP)
Q5TZ22 (/IMP)
Q6VNZ9 (/IMP)
Q6VNZ9 (/IMP)
Q9DDW0 (/IMP)
(2 more) |
|
Myoblast fate determination GO:0007518
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
8 | P29331 (/ISS) P29331 (/ISS) P49811 (/ISS) P49811 (/ISS) Q02346 (/ISS) Q0VBX9 (/ISS) Q0VBX9 (/ISS) Q7YS82 (/ISS) |
|
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
|
8 | P29331 (/ISS) P29331 (/ISS) P49811 (/ISS) P49811 (/ISS) Q02346 (/ISS) Q0VBX9 (/ISS) Q0VBX9 (/ISS) Q7YS82 (/ISS) |
|
Myoblast differentiation GO:0045445
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
|
8 | P29331 (/ISS) P29331 (/ISS) P49811 (/ISS) P49811 (/ISS) Q02346 (/ISS) Q0VBX9 (/ISS) Q0VBX9 (/ISS) Q7YS82 (/ISS) |
|
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
|
7 | P29331 (/ISS) P29331 (/ISS) P49811 (/ISS) P49811 (/ISS) Q0VBX9 (/ISS) Q0VBX9 (/ISS) Q7YS82 (/ISS) |
|
Muscle cell fate commitment GO:0042693
The process in which the cellular identity of muscle cells is acquired and determined.
|
7 | P16075 (/IDA) P17920 (/IDA) P17920 (/IDA) Q01795 (/IDA) Q01795 (/IDA) Q01795 (/IDA) Q08856 (/IDA) |
|
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
|
6 | P29331 (/ISS) P29331 (/ISS) P49811 (/ISS) P49811 (/ISS) Q02346 (/ISS) Q7YS82 (/ISS) |
|
Extraocular skeletal muscle development GO:0002074
The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.
|
6 | Q5CZP8 (/IMP) Q5TZ22 (/IMP) Q90477 (/IMP) Q9DDW0 (/IMP) Q9DE55 (/IMP) Q9I9H3 (/IMP) |
|
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
|
6 | P29331 (/ISS) P29331 (/ISS) P49811 (/ISS) P49811 (/ISS) Q0VBX9 (/ISS) Q0VBX9 (/ISS) |
|
Pharyngeal muscle development GO:0043282
The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx.
|
6 | Q5CZP8 (/IMP) Q5TZ22 (/IMP) Q90477 (/IMP) Q9DDW0 (/IMP) Q9DE55 (/IMP) Q9I9H3 (/IMP) |
|
Positive regulation of skeletal muscle tissue regeneration GO:0043415
Any process that activates or increase the rate of skeletal muscle regeneration.
|
6 | P29331 (/ISS) P29331 (/ISS) P49811 (/ISS) P49811 (/ISS) Q02346 (/ISS) Q7YS82 (/ISS) |
|
Skeletal muscle fiber development GO:0048741
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
|
6 | Q5CZP8 (/IGI) Q5TZ22 (/IGI) Q90477 (/IGI) Q9DDW0 (/IGI) Q9DE55 (/IGI) Q9I9H3 (/IGI) |
|
Striated muscle cell differentiation GO:0051146
The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.
|
6 | P29331 (/ISS) P29331 (/ISS) P49811 (/ISS) P49811 (/ISS) Q02346 (/ISS) Q7YS82 (/ISS) |
|
Positive regulation of muscle cell differentiation GO:0051149
Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.
|
6 | P29331 (/ISS) P29331 (/ISS) P49811 (/ISS) P49811 (/ISS) Q02346 (/ISS) Q7YS82 (/ISS) |
|
Striated muscle cell development GO:0055002
The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.
|
6 | Q5CZP8 (/IGI) Q5TZ22 (/IGI) Q90477 (/IGI) Q9DDW0 (/IGI) Q9DE55 (/IGI) Q9I9H3 (/IGI) |
|
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
|
5 | Q5CZP8 (/IMP) Q5TZ22 (/IMP) Q9DDW0 (/IMP) Q9DE55 (/IMP) Q9I9H3 (/IMP) |
|
Neural crest cell development GO:0014032
The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
|
5 | Q5CZP8 (/IMP) Q5TZ22 (/IMP) Q9DDW0 (/IMP) Q9DE55 (/IMP) Q9I9H3 (/IMP) |
|
Skeletal muscle cell differentiation GO:0035914
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.
|
5 | P10085 (/IMP) P15375 (/IMP) P15375 (/IMP) P24699 (/IMP) P24699 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
5 | P10085 (/IMP) P12979 (/IMP) P22980 (/IMP) P24699 (/IMP) P24699 (/IMP) |
|
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
|
4 | P15375 (/IMP) P15375 (/IMP) P24699 (/IMP) P24699 (/IMP) |
|
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
|
4 | P22816 (/IMP) P24699 (/IMP) P24699 (/IMP) Q90477 (/IMP) |
|
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
|
4 | P13349 (/TAS) P13349 (/TAS) P15172 (/TAS) P22816 (/TAS) |
|
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
|
4 | A0A0R4IN45 (/IDA) B0S6I5 (/IDA) Q66L62 (/IDA) Q9DG26 (/IDA) |
|
Myoblast differentiation involved in skeletal muscle regeneration GO:0014835
The process in which a relatively unspecialized satellite cell acquires specialized features of a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
4 | A0A0R4IN45 (/IMP) B0S6I5 (/IMP) Q66L62 (/IMP) Q9DG26 (/IMP) |
|
Myoblast proliferation involved in skeletal muscle regeneration GO:0014844
The multiplication or reproduction of myoblasts, resulting in the expansion of the cell population. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
4 | A0A0R4IN45 (/IMP) B0S6I5 (/IMP) Q66L62 (/IMP) Q9DG26 (/IMP) |
|
Myoblast differentiation GO:0045445
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
|
4 | C4P6Q3 (/IMP) C4P6Q3 (/IMP) P17920 (/IMP) P17920 (/IMP) |
|
Transdifferentiation GO:0060290
The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate.
|
4 | C4P6Q3 (/IMP) C4P6Q3 (/IMP) P17920 (/IMP) P17920 (/IMP) |
|
Muscle tissue morphogenesis GO:0060415
The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function.
|
4 | P15375 (/IMP) P15375 (/IMP) P24699 (/IMP) P24699 (/IMP) |
|
Ossification GO:0001503
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
|
3 | P12979 (/IMP) P24699 (/IMP) P24699 (/IMP) |
|
MRNA transcription by RNA polymerase II GO:0042789
The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
|
3 | P15173 (/TAS) P15173 (/TAS) P15173 (/TAS) |
|
Skeletal muscle tissue regeneration GO:0043403
The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.
|
3 | P10085 (/ISO) P15375 (/ISO) P15375 (/ISO) |
|
Skeletal muscle fiber development GO:0048741
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
|
3 | P10085 (/IMP) P12979 (/IMP) Q90477 (/IMP) |
|
Cartilage condensation GO:0001502
The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.
|
2 | P24699 (/IMP) P24699 (/IMP) |
|
Regulation of cell-matrix adhesion GO:0001952
Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix.
|
2 | P24699 (/IMP) P24699 (/IMP) |
|
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
|
2 | P10085 (/IDA) P12979 (/IDA) |
|
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
2 | C4P6Q3 (/IDA) C4P6Q3 (/IDA) |
|
Skeletal muscle atrophy GO:0014732
A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse.
|
2 | P20428 (/IEP) Q02346 (/IEP) |
|
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
|
2 | P24699 (/IMP) P24699 (/IMP) |
|
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
|
2 | P24699 (/IMP) P24699 (/IMP) |
|
Skeletal muscle tissue regeneration GO:0043403
The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.
|
2 | P20428 (/IEP) Q02346 (/IEP) |
|
Skeletal muscle tissue regeneration GO:0043403
The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.
|
2 | P19335 (/IMP) Q02346 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P15375 (/IMP) P15375 (/IMP) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P10085 (/IDA) P12979 (/IDA) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P15375 (/IMP) P15375 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P10085 (/IGI) P12979 (/IGI) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | P10085 (/ISO) P12979 (/ISO) |
|
Muscle organ morphogenesis GO:0048644
The process in which the anatomical structures of muscle are generated and organized.
|
2 | P24699 (/IGI) P24699 (/IGI) |
|
Embryonic skeletal system morphogenesis GO:0048704
The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.
|
2 | P24699 (/IMP) P24699 (/IMP) |
|
Striated muscle cell differentiation GO:0051146
The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.
|
2 | P10085 (/IMP) P22980 (/IMP) |
|
Positive regulation of muscle cell differentiation GO:0051149
Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.
|
2 | P10085 (/IDA) P15172 (/IDA) |
|
Muscle tissue morphogenesis GO:0060415
The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function.
|
2 | P24699 (/IGI) P24699 (/IGI) |
|
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
2 | P10085 (/IDA) P12979 (/IDA) |
|
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
2 | P10085 (/IDA) P12979 (/IDA) |
|
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
|
1 | P10085 (/IDA) |
|
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
|
1 | P10085 (/IMP) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q7YS82 (/ISS) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P10085 (/IDA) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
1 | P22980 (/IDA) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | P15172 (/TAS) |
|
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
|
1 | P10085 (/IDA) |
|
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
|
1 | P16075 (/NAS) |
|
Myoblast fate determination GO:0007518
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
1 | P10085 (/IDA) |
|
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
|
1 | Q90477 (/IEP) |
|
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
1 | P10085 (/IMP) |
|
Larval somatic muscle development GO:0007526
The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure.
|
1 | P22816 (/IMP) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | P12979 (/IDA) |
|
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
|
1 | P10085 (/IDA) |
|
Response to gravity GO:0009629
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus.
|
1 | P20428 (/IEP) |
|
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | P10085 (/IDA) |
|
Positive regulation of myotube differentiation GO:0010831
Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
|
1 | P12979 (/IDA) |
|
Positive regulation of muscle atrophy GO:0014737
Any process that activates or increases the frequency, rate or extent of muscle atrophy.
|
1 | P12979 (/IMP) |
|
Regulation of skeletal muscle satellite cell proliferation GO:0014842
Any process that modulates the frequency, rate or extent of skeletal muscle satellite cell proliferation.
|
1 | P12979 (/IMP) |
|
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
|
1 | P20428 (/IEP) |
|
Response to muscle activity involved in regulation of muscle adaptation GO:0014873
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation.
|
1 | P20428 (/IDA) |
|
Response to muscle activity involved in regulation of muscle adaptation GO:0014873
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation.
|
1 | P12979 (/ISO) |
|
Response to electrical stimulus involved in regulation of muscle adaptation GO:0014878
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation.
|
1 | P20428 (/IDA) |
|
Response to electrical stimulus involved in regulation of muscle adaptation GO:0014878
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation.
|
1 | P20428 (/IEP) |
|
Response to electrical stimulus involved in regulation of muscle adaptation GO:0014878
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation.
|
1 | P12979 (/ISO) |
|
Striated muscle atrophy GO:0014891
A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse.
|
1 | P12979 (/IMP) |
|
Response to denervation involved in regulation of muscle adaptation GO:0014894
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation.
|
1 | P12979 (/IDA) |
|
Myotube differentiation GO:0014902
The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
|
1 | P10085 (/IDA) |
|
Myotube differentiation GO:0014902
The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
|
1 | P12979 (/IGI) |
|
Myotube differentiation GO:0014902
The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
|
1 | P20428 (/IMP) |
|
Myotube differentiation GO:0014902
The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
|
1 | P12979 (/ISO) |
|
Myotube cell development GO:0014904
The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
|
1 | P15172 (/IDA) |
|
Myotube cell development GO:0014904
The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
|
1 | P10085 (/ISO) |
|
Myotube differentiation involved in skeletal muscle regeneration GO:0014908
The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. This process occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
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1 | P10085 (/IMP) |
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Regulation of striated muscle tissue development GO:0016202
Any process that modulates the frequency, rate or extent of striated muscle development.
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1 | P22816 (/TAS) |
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Determination of muscle attachment site GO:0016204
The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site.
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1 | P22816 (/IMP) |
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Skeletal muscle cell differentiation GO:0035914
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.
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1 | Q90477 (/IGI) |
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Skeletal muscle cell differentiation GO:0035914
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.
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1 | P10085 (/NAS) |
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Response to muscle stretch GO:0035994
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length.
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1 | Q02346 (/IEP) |
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MRNA transcription by RNA polymerase II GO:0042789
The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
|
1 | P12979 (/IC) |
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Positive regulation of skeletal muscle tissue regeneration GO:0043415
Any process that activates or increase the rate of skeletal muscle regeneration.
|
1 | P10085 (/IMP) |
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Regulation of RNA splicing GO:0043484
Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
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1 | P15172 (/IDA) |
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Regulation of RNA splicing GO:0043484
Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
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1 | P10085 (/ISO) |
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Skeletal muscle fiber adaptation GO:0043503
Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
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1 | P10085 (/IMP) |
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Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
|
1 | P10085 (/IDA) |
|
Histone H4 acetylation GO:0043967
The modification of histone H4 by the addition of an acetyl group.
|
1 | P10085 (/IDA) |
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Cellular response to fibroblast growth factor stimulus GO:0044344
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.
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1 | P13904 (/IGI) |
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Myoblast differentiation GO:0045445
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
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1 | P10085 (/IDA) |
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Myoblast differentiation GO:0045445
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
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1 | P20428 (/IEP) |
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Positive regulation of myoblast differentiation GO:0045663
Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
1 | P12979 (/IDA) |
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Negative regulation of glycolytic process GO:0045820
Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
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1 | P20428 (/IDA) |
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Negative regulation of glycolytic process GO:0045820
Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.
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1 | P12979 (/ISO) |
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Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
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1 | P12979 (/IC) |
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Positive regulation of mesodermal cell fate specification GO:0048337
Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification.
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1 | P22980 (/IGI) |
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Positive regulation of skeletal muscle fiber development GO:0048743
Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
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1 | P12979 (/IMP) |
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Positive regulation of muscle cell differentiation GO:0051149
Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.
|
1 | P10085 (/ISO) |
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Cardiac muscle cell differentiation GO:0055007
The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
|
1 | P10085 (/NAS) |
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Positive regulation of cell cycle arrest GO:0071158
Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.
|
1 | P12979 (/IDA) |
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Cellular response to magnetism GO:0071259
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus.
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1 | P20428 (/IEP) |
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Cellular response to lithium ion GO:0071285
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
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1 | P12979 (/IDA) |
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Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
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1 | P20428 (/IEP) |
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Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
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1 | P12979 (/IDA) |
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Cellular response to glucocorticoid stimulus GO:0071385
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
|
1 | P10085 (/IDA) |
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Cellular response to oxygen levels GO:0071453
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.
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1 | P10085 (/IDA) |
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Regulation of myoblast fusion GO:1901739
Any process that modulates the frequency, rate or extent of myoblast fusion.
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1 | P12979 (/IMP) |
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Positive regulation of myoblast fusion GO:1901741
Any process that activates or increases the frequency, rate or extent of myoblast fusion.
|
1 | P15172 (/IDA) |
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Positive regulation of myoblast fusion GO:1901741
Any process that activates or increases the frequency, rate or extent of myoblast fusion.
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1 | P10085 (/ISO) |
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Positive regulation of oxidative phosphorylation GO:1903862
Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation.
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1 | P20428 (/IDA) |
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Positive regulation of oxidative phosphorylation GO:1903862
Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation.
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1 | P12979 (/ISO) |
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Positive regulation of snRNA transcription by RNA polymerase II GO:1905382
Any process that activates or increases the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II.
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1 | P10085 (/IMP) |
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Negative regulation of myoblast proliferation GO:2000818
Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation.
|
1 | P10085 (/IMP) |
There are 23 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
21 |
P10085 (/TAS)
P12979 (/TAS)
P15172 (/TAS)
P15375 (/TAS)
P15375 (/TAS)
P22816 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
(11 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
20 |
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P29331 (/ISS)
P29331 (/ISS)
P34060 (/ISS)
P49811 (/ISS)
P49811 (/ISS)
(10 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
20 |
P10085 (/TAS)
P13349 (/TAS)
P13349 (/TAS)
P15172 (/TAS)
P15173 (/TAS)
P15173 (/TAS)
P15173 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
P23409 (/TAS)
(10 more) |
|
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
|
15 |
P13349 (/ISS)
P13349 (/ISS)
P23409 (/ISS)
P23409 (/ISS)
P23409 (/ISS)
P23409 (/ISS)
P23409 (/ISS)
P23409 (/ISS)
P23409 (/ISS)
P23409 (/ISS)
(5 more) |
|
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
|
13 |
P12979 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P17920 (/ISS)
P17920 (/ISS)
P34060 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
P49812 (/ISS)
(3 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
11 |
P13349 (/IDA)
P13349 (/IDA)
P15172 (/IDA)
P15173 (/IDA)
P15173 (/IDA)
P15173 (/IDA)
Q5CZP8 (/IDA)
Q5TZ22 (/IDA)
Q9DDW0 (/IDA)
Q9DE55 (/IDA)
(1 more) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
11 |
P15172 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P15173 (/ISS)
P29331 (/ISS)
P29331 (/ISS)
P49811 (/ISS)
P49811 (/ISS)
Q0VBX9 (/ISS)
Q0VBX9 (/ISS)
(1 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | P10085 (/IDA) P12979 (/IDA) P20428 (/IDA) P22816 (/IDA) P22980 (/IDA) Q02346 (/IDA) Q90477 (/IDA) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
5 | Q5CZP8 (/IDA) Q5TZ22 (/IDA) Q9DDW0 (/IDA) Q9DE55 (/IDA) Q9I9H3 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | P10085 (/ISO) P12979 (/ISO) P24699 (/ISO) P24699 (/ISO) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
4 | P10085 (/IDA) P16075 (/IDA) P17920 (/IDA) P17920 (/IDA) |
|
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
|
4 | Q01795 (/IDA) Q01795 (/IDA) Q01795 (/IDA) Q08856 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P10085 (/ISO) P12979 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P10085 (/IDA) P22816 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | P10085 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | P15172 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P15172 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P10085 (/ISO) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
1 | P15172 (/IDA) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
1 | P10085 (/ISO) |
|
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
|
1 | P10085 (/IDA) |
|
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
|
1 | P20428 (/IDA) |
|
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
|
1 | P12979 (/ISO) |