The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Helix-loop-helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 41: aryl hydrocarbon receptor repressor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Core promoter sequence-specific DNA binding GO:0001046
Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
19 A0A087QWY7 (/ISS) A0A091F9I0 (/ISS) A0A091FM79 (/ISS) A0A091JIQ5 (/ISS) A0A091KUF4 (/ISS) A0A091NYV0 (/ISS) A0A091VLH0 (/ISS) A0A091WLL3 (/ISS) A0A093BMQ1 (/ISS) A0A093C9U5 (/ISS)
(9 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
19 A0A087QWY7 (/ISS) A0A091F9I0 (/ISS) A0A091FM79 (/ISS) A0A091JIQ5 (/ISS) A0A091KUF4 (/ISS) A0A091NYV0 (/ISS) A0A091VLH0 (/ISS) A0A091WLL3 (/ISS) A0A093BMQ1 (/ISS) A0A093C9U5 (/ISS)
(9 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
3 E1JIM6 (/IPI) O61543 (/IPI) Q9VEV9 (/IPI)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 A9YTQ3 (/ISA)
Core promoter sequence-specific DNA binding GO:0001046
Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
1 E5L8C8 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q3T2L3 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 A9YTQ3 (/IPI)
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
1 E5L8C8 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 E5L8C8 (/IDA)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
19 A0A087QWY7 (/ISS) A0A091F9I0 (/ISS) A0A091FM79 (/ISS) A0A091JIQ5 (/ISS) A0A091KUF4 (/ISS) A0A091NYV0 (/ISS) A0A091VLH0 (/ISS) A0A091WLL3 (/ISS) A0A093BMQ1 (/ISS) A0A093C9U5 (/ISS)
(9 more)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
5 A0A2R8PV59 (/IMP) B0S7S2 (/IMP) B3DIG9 (/IMP) Q3T2L2 (/IMP) Q3T2L3 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
5 A0A2R8PV59 (/IDA) B0S7S2 (/IDA) B3DIG9 (/IDA) Q3T2L2 (/IDA) Q3T2L3 (/IDA)
Cellular response to xenobiotic stimulus GO:0071466
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
5 A0A2R8PV59 (/IDA) B0S7S2 (/IDA) B3DIG9 (/IDA) Q3T2L2 (/IDA) Q3T2L3 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 E1JIM6 (/IMP) O61543 (/IMP) Q9VEV9 (/IMP)
Antennal development GO:0007469
The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli.
3 E1JIM6 (/IEP) O61543 (/IEP) Q9VEV9 (/IEP)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
3 E1JIM6 (/IMP) O61543 (/IMP) Q9VEV9 (/IMP)
Male courtship behavior GO:0008049
The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster.
3 E1JIM6 (/IMP) O61543 (/IMP) Q9VEV9 (/IMP)
Specification of animal organ identity GO:0010092
The regionalization process in which the identity of an animal organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
3 E1JIM6 (/IMP) O61543 (/IMP) Q9VEV9 (/IMP)
Imaginal disc-derived leg segmentation GO:0036011
Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint.
3 E1JIM6 (/IMP) O61543 (/IMP) Q9VEV9 (/IMP)
Regulation of R7 cell differentiation GO:0045676
Any process that modulates the frequency, rate or extent of R7 differentiation.
3 E1JIM6 (/IMP) O61543 (/IMP) Q9VEV9 (/IMP)
Antennal morphogenesis GO:0048800
The process in which the anatomical structures of the antenna are generated and organized.
3 E1JIM6 (/IMP) O61543 (/IMP) Q9VEV9 (/IMP)
Regulation of dendrite morphogenesis GO:0048814
Any process that modulates the frequency, rate or extent of dendrite morphogenesis.
3 E1JIM6 (/IMP) O61543 (/IMP) Q9VEV9 (/IMP)
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
2 A9YTQ3 (/TAS) Q3U1U7 (/TAS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q3U1U7 (/IDA)
Regulation of rhodopsin gene expression GO:0007468
Any process that modulates the frequency, rate or extent of rhodopsin gene expression. This includes transcriptional, translational, or posttranslational regulation.
1 E1JIM6 (/IMP)
Response to xenobiotic stimulus GO:0009410
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
1 Q3U1U7 (/IC)
Positive regulation of protein sumoylation GO:0033235
Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein.
1 Q3U1U7 (/IDA)
R7 cell differentiation GO:0045466
The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor.
1 E1JIM6 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q3U1U7 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 E5L8C8 (/IMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
19 A0A087QWY7 (/ISS) A0A091F9I0 (/ISS) A0A091FM79 (/ISS) A0A091JIQ5 (/ISS) A0A091KUF4 (/ISS) A0A091NYV0 (/ISS) A0A091VLH0 (/ISS) A0A091WLL3 (/ISS) A0A093BMQ1 (/ISS) A0A093C9U5 (/ISS)
(9 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 E1JIM6 (/IDA) O61543 (/IDA) Q3T2L3 (/IDA) Q3U1U7 (/IDA) Q9VEV9 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 E1JIM6 (/HDA) O61543 (/HDA) Q9VEV9 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 A9YTQ3 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q3U1U7 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 A9YTQ3 (/TAS)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
1 E5L8C8 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 A9YTQ3 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q3U1U7 (/ISO)
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