The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Helix-loop-helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 33: Transcription factor HES-5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
3 P70120 (/NAS) P70120 (/NAS) Q5TA89 (/NAS)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 P70120 (/IDA) P70120 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 P70120 (/ISO) P70120 (/ISO)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
2 Q03062 (/IDA) Q90466 (/IDA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
2 P70120 (/ISO) P70120 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P70120 (/IPI) P70120 (/IPI)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q5TA89 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q5TA89 (/ISM)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q03062 (/IDA)

There are 108 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
6 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) P70120 (/ISS) P70120 (/ISS) Q03062 (/ISS)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
6 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) P70120 (/ISS) P70120 (/ISS) Q03062 (/ISS)
Peripheral nervous system neuron axonogenesis GO:0048936
Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells.
6 B0V3D1 (/IGI) B0V3D2 (/IGI) B0V3D3 (/IGI) B0V3D4 (/IGI) Q7ZUF1 (/IGI) Q90466 (/IGI)
Negative regulation of stem cell differentiation GO:2000737
Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.
6 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) P70120 (/ISS) P70120 (/ISS) Q03062 (/ISS)
Negative regulation of pro-B cell differentiation GO:2000974
Any process that stops, prevents or reduces the frequency, rate or extent of pro-B cell differentiation.
6 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) P70120 (/ISS) P70120 (/ISS) Q5TA89 (/ISS)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Telencephalon development GO:0021537
The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Glial cell fate commitment GO:0021781
The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Neural tube development GO:0021915
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Central nervous system myelination GO:0022010
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Positive regulation of BMP signaling pathway GO:0030513
Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Regulation of myelination GO:0031641
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Regulation of cell differentiation GO:0045595
Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Astrocyte differentiation GO:0048708
The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Negative regulation of astrocyte differentiation GO:0048712
Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Negative regulation of oligodendrocyte differentiation GO:0048715
Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
5 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS) Q5TA89 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
4 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q5TA89 (/ISS)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 P70120 (/IMP) P70120 (/IMP) Q5TA89 (/IMP) Q90466 (/IMP)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
4 P70120 (/IMP) P70120 (/IMP) Q4QRL6 (/IMP) Q6TA36 (/IMP)
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
4 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS) Q03062 (/ISS)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 Q4QRL6 (/IGI) Q6TA36 (/IGI) Q7T3J0 (/IGI)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 P70120 (/TAS) P70120 (/TAS) Q5TA89 (/TAS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
3 A6H787 (/ISS) E2QXY9 (/ISS) E2QXY9 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P70120 (/IGI) P70120 (/IGI)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P70120 (/IMP) P70120 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P70120 (/ISO) P70120 (/ISO)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
2 Q4QRL6 (/IMP) Q6TA36 (/IMP)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
2 P70120 (/IGI) P70120 (/IGI)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P70120 (/IDA) P70120 (/IDA)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P70120 (/ISO) P70120 (/ISO)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P70120 (/NAS) P70120 (/NAS)
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2 P70120 (/IDA) P70120 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 P70120 (/ISO) P70120 (/ISO)
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
2 P70120 (/IMP) P70120 (/IMP)
Telencephalon development GO:0021537
The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.
2 P70120 (/IGI) P70120 (/IGI)
Glial cell fate commitment GO:0021781
The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell.
2 P70120 (/IMP) P70120 (/IMP)
Forebrain radial glial cell differentiation GO:0021861
The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2 P70120 (/ISO) P70120 (/ISO)
Neural tube development GO:0021915
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
2 P70120 (/IGI) P70120 (/IGI)
Central nervous system myelination GO:0022010
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
2 P70120 (/IMP) P70120 (/IMP)
Positive regulation of BMP signaling pathway GO:0030513
Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
2 P70120 (/IGI) P70120 (/IGI)
Regulation of myelination GO:0031641
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
2 P70120 (/IMP) P70120 (/IMP)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
2 P70120 (/IDA) P70120 (/IDA)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
2 P70120 (/IMP) P70120 (/IMP)
Regulation of cell differentiation GO:0045595
Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
2 P70120 (/IMP) P70120 (/IMP)
Negative regulation of inner ear auditory receptor cell differentiation GO:0045608
Any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation.
2 P70120 (/IGI) P70120 (/IGI)
Negative regulation of inner ear auditory receptor cell differentiation GO:0045608
Any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation.
2 P70120 (/IMP) P70120 (/IMP)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
2 P70120 (/IGI) P70120 (/IGI)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
2 P70120 (/IMP) P70120 (/IMP)
Positive regulation of Notch signaling pathway GO:0045747
Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
2 P70120 (/IMP) P70120 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P70120 (/IMP) P70120 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P70120 (/ISO) P70120 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P70120 (/IMP) P70120 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P70120 (/IGI) P70120 (/IGI)
Positive regulation of receptor signaling pathway via JAK-STAT GO:0046427
Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.
2 P70120 (/IDA) P70120 (/IDA)
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
2 P70120 (/IGI) P70120 (/IGI)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
2 P70120 (/ISO) P70120 (/ISO)
Astrocyte differentiation GO:0048708
The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
2 P70120 (/IDA) P70120 (/IDA)
Negative regulation of astrocyte differentiation GO:0048712
Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation.
2 P70120 (/IDA) P70120 (/IDA)
Negative regulation of oligodendrocyte differentiation GO:0048715
Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.
2 P70120 (/IDA) P70120 (/IDA)
Negative regulation of oligodendrocyte differentiation GO:0048715
Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.
2 P70120 (/IMP) P70120 (/IMP)
Regulation of epithelial cell proliferation GO:0050678
Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
2 P70120 (/IGI) P70120 (/IGI)
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
2 P70120 (/IGI) P70120 (/IGI)
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
2 P70120 (/IMP) P70120 (/IMP)
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
2 P70120 (/ISO) P70120 (/ISO)
Inner ear receptor cell stereocilium organization GO:0060122
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells.
2 P70120 (/IGI) P70120 (/IGI)
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
2 P70120 (/IDA) P70120 (/IDA)
Comma-shaped body morphogenesis GO:0072049
The process in which the comma-shaped body is generated and organized. The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron.
2 P70120 (/IEP) P70120 (/IEP)
S-shaped body morphogenesis GO:0072050
The process in which the S-shaped body is generated and organized. The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron.
2 P70120 (/IEP) P70120 (/IEP)
Specification of loop of Henle identity GO:0072086
The process in which the loop of Henle of the kidney nephron acquires its identity.
2 P70120 (/IEP) P70120 (/IEP)
Metanephric nephron tubule morphogenesis GO:0072282
The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros.
2 P70120 (/IEP) P70120 (/IEP)
Establishment of epithelial cell polarity GO:0090162
The specification and formation of anisotropic intracellular organization of an epithelial cell.
2 P70120 (/IGI) P70120 (/IGI)
Neuronal stem cell population maintenance GO:0097150
Any process in by an organism or tissue maintains a population of neuronal stem cells.
2 P70120 (/IMP) P70120 (/IMP)
Neuronal stem cell population maintenance GO:0097150
Any process in by an organism or tissue maintains a population of neuronal stem cells.
2 P70120 (/ISO) P70120 (/ISO)
Neuronal stem cell population maintenance GO:0097150
Any process in by an organism or tissue maintains a population of neuronal stem cells.
2 E2QXY9 (/ISS) E2QXY9 (/ISS)
Negative regulation of stem cell differentiation GO:2000737
Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.
2 P70120 (/ISO) P70120 (/ISO)
Negative regulation of pro-B cell differentiation GO:2000974
Any process that stops, prevents or reduces the frequency, rate or extent of pro-B cell differentiation.
2 P70120 (/ISO) P70120 (/ISO)
Negative regulation of forebrain neuron differentiation GO:2000978
Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation.
2 P70120 (/ISO) P70120 (/ISO)
Negative regulation of inner ear receptor cell differentiation GO:2000981
Any process that stops, prevents or reduces the frequency, rate or extent of inner ear receptor cell differentiation.
2 P70120 (/IMP) P70120 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q03062 (/IDA)
Eye development GO:0001654
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
1 Q7T3J0 (/IDA)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
1 Q7T3J0 (/IDA)
Somite specification GO:0001757
The process in which individual somites establish identity during embryogenesis.
1 Q90466 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 Q7T3J0 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q5TA89 (/IMP)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
1 Q90466 (/IGI)
Forebrain radial glial cell differentiation GO:0021861
The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
1 Q03062 (/IDA)
Adenohypophysis development GO:0021984
The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus.
1 Q90466 (/IMP)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 Q03062 (/IEP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q03062 (/IDA)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
1 Q5TA89 (/IGI)
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
1 Q5TA89 (/IDA)
Neuronal stem cell population maintenance GO:0097150
Any process in by an organism or tissue maintains a population of neuronal stem cells.
1 Q03062 (/IDA)
Neuronal stem cell population maintenance GO:0097150
Any process in by an organism or tissue maintains a population of neuronal stem cells.
1 Q5TA89 (/IEP)
Negative regulation of stem cell differentiation GO:2000737
Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.
1 Q5TA89 (/IMP)
Negative regulation of pro-B cell differentiation GO:2000974
Any process that stops, prevents or reduces the frequency, rate or extent of pro-B cell differentiation.
1 Q03062 (/IMP)
Negative regulation of forebrain neuron differentiation GO:2000978
Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation.
1 Q03062 (/IDA)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 P70120 (/TAS) P70120 (/TAS) Q5TA89 (/TAS)
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