The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Helix-loop-helix DNA-binding domain
".
FunFam 31: Oligodendrocyte transcription factor 3
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
7 | G3V612 (/IPI) Q7RTU3 (/IPI) Q8TAK6 (/IPI) Q9EQW6 (/IPI) Q9EQW6 (/IPI) Q9JKN5 (/IPI) Q9JKN5 (/IPI) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
5 | Q13516 (/ISA) Q13516 (/ISA) Q13516 (/ISA) Q7RTU3 (/ISA) Q8TAK6 (/ISA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
5 | Q13516 (/ISM) Q13516 (/ISM) Q13516 (/ISM) Q7RTU3 (/ISM) Q8TAK6 (/ISM) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
4 | Q13516 (/NAS) Q13516 (/NAS) Q13516 (/NAS) Q8TAK6 (/NAS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
4 | A8WIQ7 (/IDA) Q5QJR2 (/IDA) Q9EQW6 (/IDA) Q9EQW6 (/IDA) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
4 | Q9EQW6 (/ISS) Q9EQW6 (/ISS) Q9JKN5 (/ISS) Q9JKN5 (/ISS) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | Q9EQW6 (/IDA) Q9EQW6 (/IDA) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | Q9EQW6 (/IPI) Q9EQW6 (/IPI) |
|
HMG box domain binding GO:0071837
Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin.
|
2 | Q9EQW6 (/IPI) Q9EQW6 (/IPI) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | Q6PFG8 (/IDA) |
There are 30 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Spinal cord motor neuron differentiation GO:0021522
The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
|
7 | A8WIQ8 (/IMP) Q6P0J2 (/IMP) Q6PFG8 (/IMP) Q6PG32 (/IMP) Q8QGI4 (/IMP) Q9EQW6 (/IMP) Q9EQW6 (/IMP) |
|
Oligodendrocyte differentiation GO:0048709
The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.
|
6 | A8WIQ8 (/IMP) Q6P0J2 (/IMP) Q6PG32 (/IMP) Q8QGI4 (/IMP) Q9EQW6 (/IMP) Q9EQW6 (/IMP) |
|
Spinal cord motor neuron cell fate specification GO:0021520
The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.
|
5 | A8WIQ8 (/IMP) Q6P0J2 (/IMP) Q6PFG8 (/IMP) Q6PG32 (/IMP) Q8QGI4 (/IMP) |
|
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
4 | A8WIQ8 (/IMP) Q6P0J2 (/IMP) Q6PG32 (/IMP) Q8QGI4 (/IMP) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | Q9EQW6 (/ISS) Q9EQW6 (/ISS) Q9JKN5 (/ISS) Q9JKN5 (/ISS) |
|
Neuroblast fate determination GO:0007400
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus.
|
4 | A8WIQ8 (/IMP) Q6P0J2 (/IMP) Q6PG32 (/IMP) Q8QGI4 (/IMP) |
|
Glial cell fate determination GO:0007403
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed.
|
4 | A8WIQ8 (/IMP) Q6P0J2 (/IMP) Q6PG32 (/IMP) Q8QGI4 (/IMP) |
|
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
|
4 | A8WIQ8 (/IMP) Q6P0J2 (/IMP) Q6PG32 (/IMP) Q8QGI4 (/IMP) |
|
Ventral spinal cord interneuron differentiation GO:0021514
The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate.
|
4 | A8WIQ8 (/IMP) Q6P0J2 (/IMP) Q6PG32 (/IMP) Q8QGI4 (/IMP) |
|
Abducens nucleus development GO:0021742
The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure.
|
4 | A8WIQ8 (/IMP) Q6P0J2 (/IMP) Q6PG32 (/IMP) Q8QGI4 (/IMP) |
|
Facial nucleus development GO:0021754
The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure.
|
4 | A8WIQ8 (/IMP) Q6P0J2 (/IMP) Q6PG32 (/IMP) Q8QGI4 (/IMP) |
|
Neuron fate commitment GO:0048663
The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.
|
4 | Q9EQW6 (/IMP) Q9EQW6 (/IMP) Q9JKN5 (/IMP) Q9JKN5 (/IMP) |
|
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
|
4 | A8WIQ8 (/IMP) Q6P0J2 (/IMP) Q6PG32 (/IMP) Q8QGI4 (/IMP) |
|
Positive regulation of neurogenesis GO:0050769
Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
|
4 | A8WIQ8 (/IMP) Q6P0J2 (/IMP) Q6PG32 (/IMP) Q8QGI4 (/IMP) |
|
Dopaminergic neuron differentiation GO:0071542
The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
|
4 | A8WIQ8 (/IGI) Q6P0J2 (/IGI) Q6PG32 (/IGI) Q8QGI4 (/IGI) |
|
Dopaminergic neuron differentiation GO:0071542
The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
|
4 | A8WIQ8 (/IMP) Q6P0J2 (/IMP) Q6PG32 (/IMP) Q8QGI4 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | Q6PFG8 (/IDA) Q9EQW6 (/IDA) Q9EQW6 (/IDA) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q9EQW6 (/IDA) Q9EQW6 (/IDA) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
2 | Q9EQW6 (/IDA) Q9EQW6 (/IDA) |
|
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
|
2 | A8WIQ7 (/IGI) Q5QJR2 (/IGI) |
|
Spinal cord oligodendrocyte cell differentiation GO:0021529
The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate.
|
2 | Q9EQW6 (/IGI) Q9EQW6 (/IGI) |
|
Spinal cord oligodendrocyte cell fate specification GO:0021530
The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway.
|
2 | Q9EQW6 (/IDA) Q9EQW6 (/IDA) |
|
Thalamus development GO:0021794
The process in which the thalamus changes over time, from its initial formation to its mature state.
|
2 | Q9EQW6 (/IMP) Q9EQW6 (/IMP) |
|
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
|
2 | Q9EQW6 (/IMP) Q9EQW6 (/IMP) |
|
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
|
2 | Q9EQW6 (/IDA) Q9EQW6 (/IDA) |
|
Positive regulation of oligodendrocyte differentiation GO:0048714
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
|
2 | Q9EQW6 (/IGI) Q9EQW6 (/IGI) |
|
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q6PFG8 (/IMP) |
|
Spinal cord motor neuron differentiation GO:0021522
The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
|
1 | Q6PFG8 (/IGI) |
|
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
|
1 | Q5K548 (/IMP) |
|
Spinal cord motor neuron migration GO:0097476
The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.
|
1 | Q6PFG8 (/IMP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | Q90XB3 (/IDA) Q90XB3 (/IDA) Q9EQW6 (/IDA) Q9EQW6 (/IDA) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
4 | Q9EQW6 (/ISS) Q9EQW6 (/ISS) Q9JKN5 (/ISS) Q9JKN5 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q9EQW6 (/IDA) Q9EQW6 (/IDA) |
