The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Helix-loop-helix DNA-binding domain
".
FunFam 27: Nescient helix-loop-helix 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
28 |
Q02577 (/IPI)
Q02577 (/IPI)
Q02577 (/IPI)
Q02577 (/IPI)
Q02577 (/IPI)
Q02577 (/IPI)
Q02577 (/IPI)
Q02577 (/IPI)
Q02577 (/IPI)
Q02577 (/IPI)
(18 more) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
27 |
Q02575 (/ISA)
Q02575 (/ISA)
Q02575 (/ISA)
Q02575 (/ISA)
Q02575 (/ISA)
Q02575 (/ISA)
Q02575 (/ISA)
Q02575 (/ISA)
Q02575 (/ISA)
Q02575 (/ISA)
(17 more) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
27 |
Q02575 (/ISM)
Q02575 (/ISM)
Q02575 (/ISM)
Q02575 (/ISM)
Q02575 (/ISM)
Q02575 (/ISM)
Q02575 (/ISM)
Q02575 (/ISM)
Q02575 (/ISM)
Q02575 (/ISM)
(17 more) |
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
17 |
Q02577 (/IPI)
Q02577 (/IPI)
Q02577 (/IPI)
Q02577 (/IPI)
Q02577 (/IPI)
Q02577 (/IPI)
Q02577 (/IPI)
Q02577 (/IPI)
Q02577 (/IPI)
Q02577 (/IPI)
(7 more) |
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
11 |
Q02575 (/IDA)
Q02575 (/IDA)
Q02575 (/IDA)
Q02575 (/IDA)
Q02575 (/IDA)
Q02575 (/IDA)
Q02575 (/IDA)
Q02575 (/IDA)
Q02575 (/IDA)
Q02575 (/IDA)
(1 more) |
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
|
10 | Q02575 (/IDA) Q02575 (/IDA) Q02575 (/IDA) Q02575 (/IDA) Q02575 (/IDA) Q02575 (/IDA) Q02575 (/IDA) Q02575 (/IDA) Q02575 (/IDA) Q02575 (/IDA) |
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
|
1 | Q02576 (/ISO) |
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | Q64221 (/IDA) |
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
1 | Q64221 (/ISO) |
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | Q02576 (/ISO) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
|
27 |
Q02575 (/TAS)
Q02575 (/TAS)
Q02575 (/TAS)
Q02575 (/TAS)
Q02575 (/TAS)
Q02575 (/TAS)
Q02575 (/TAS)
Q02575 (/TAS)
Q02575 (/TAS)
Q02575 (/TAS)
(17 more) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
17 |
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
(7 more) |
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
17 |
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
(7 more) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
11 |
Q02575 (/IDA)
Q02575 (/IDA)
Q02575 (/IDA)
Q02575 (/IDA)
Q02575 (/IDA)
Q02575 (/IDA)
Q02575 (/IDA)
Q02575 (/IDA)
Q02575 (/IDA)
Q02575 (/IDA)
(1 more) |
Mating behavior GO:0007617
The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.
|
1 | Q64221 (/IMP) |
Ovulation cycle GO:0042698
The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.
|
1 | Q64221 (/IMP) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q02576 (/ISO) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
17 |
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
Q02577 (/TAS)
(7 more) |