The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Helix-loop-helix DNA-binding domain
".
FunFam 20: class E basic helix-loop-helix protein 40
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 43 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
11 |
O14503 (/IDA)
O14503 (/IDA)
O14503 (/IDA)
O14503 (/IDA)
O35185 (/IDA)
O35185 (/IDA)
Q99PV5 (/IDA)
Q99PV5 (/IDA)
Q9C0J9 (/IDA)
Q9C0J9 (/IDA)
(1 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
11 |
O14503 (/IPI)
O14503 (/IPI)
O14503 (/IPI)
O14503 (/IPI)
O35185 (/IPI)
O35185 (/IPI)
Q99PV5 (/IPI)
Q99PV5 (/IPI)
Q9C0J9 (/IPI)
Q9C0J9 (/IPI)
(1 more) |
|
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
|
11 |
O14503 (/IDA)
O14503 (/IDA)
O14503 (/IDA)
O14503 (/IDA)
O35185 (/IDA)
O35185 (/IDA)
Q99PV5 (/IDA)
Q99PV5 (/IDA)
Q9C0J9 (/IDA)
Q9C0J9 (/IDA)
(1 more) |
|
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
|
9 | O14503 (/IPI) O14503 (/IPI) O14503 (/IPI) O14503 (/IPI) Q99PV5 (/IPI) Q99PV5 (/IPI) Q9C0J9 (/IPI) Q9C0J9 (/IPI) Q9C0J9 (/IPI) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
9 | O14503 (/IPI) O14503 (/IPI) O14503 (/IPI) O14503 (/IPI) Q99PV5 (/IPI) Q99PV5 (/IPI) Q9C0J9 (/IPI) Q9C0J9 (/IPI) Q9C0J9 (/IPI) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
8 | O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) O35185 (/IDA) O35185 (/IDA) Q99PV5 (/IDA) Q99PV5 (/IDA) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
8 | O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) O35185 (/IDA) O35185 (/IDA) Q99PV5 (/IDA) Q99PV5 (/IDA) |
|
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
|
8 | B3F209 (/ISS) O35780 (/ISS) Q5EA15 (/ISS) Q5EA15 (/ISS) Q5RAI7 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
7 | O14503 (/ISA) O14503 (/ISA) O14503 (/ISA) O14503 (/ISA) Q9C0J9 (/ISA) Q9C0J9 (/ISA) Q9C0J9 (/ISA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
7 | O14503 (/ISM) O14503 (/ISM) O14503 (/ISM) O14503 (/ISM) Q9C0J9 (/ISM) Q9C0J9 (/ISM) Q9C0J9 (/ISM) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
7 | O14503 (/ISS) O14503 (/ISS) O14503 (/ISS) O14503 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
7 | O14503 (/ISS) O14503 (/ISS) O14503 (/ISS) O14503 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) |
|
MRF binding GO:0043426
Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors.
|
7 | O14503 (/ISS) O14503 (/ISS) O14503 (/ISS) O14503 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
6 | B3F209 (/ISS) O35779 (/ISS) O35780 (/ISS) Q5EA15 (/ISS) Q5EA15 (/ISS) Q5RAI7 (/ISS) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
4 | O35185 (/IDA) O35185 (/IDA) Q99PV5 (/IDA) Q99PV5 (/IDA) |
|
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
|
4 | O35185 (/IDA) O35185 (/IDA) Q99PV5 (/IDA) Q99PV5 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
4 | O14503 (/NAS) O14503 (/NAS) O14503 (/NAS) O14503 (/NAS) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
4 | O35185 (/IDA) O35185 (/IDA) Q99PV5 (/IDA) Q99PV5 (/IDA) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
4 | O14503 (/NAS) O14503 (/NAS) O14503 (/NAS) O14503 (/NAS) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
4 | O14503 (/IPI) O14503 (/IPI) O14503 (/IPI) O14503 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
4 | O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) |
|
MRF binding GO:0043426
Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors.
|
4 | O35185 (/IDA) O35185 (/IDA) Q99PV5 (/IDA) Q99PV5 (/IDA) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
4 | O35185 (/IDA) O35185 (/IDA) Q99PV5 (/IDA) Q99PV5 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
3 | Q9C0J9 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
3 | Q9C0J9 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
3 | Q9C0J9 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
3 | Q9C0J9 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) |
|
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
|
3 | Q9C0J9 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
3 | Q9C0J9 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | O35185 (/ISO) O35185 (/ISO) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
2 | Q99PV5 (/IPI) Q99PV5 (/IPI) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | O35185 (/ISO) O35185 (/ISO) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | O35185 (/IDA) O35185 (/IDA) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
2 | O35185 (/ISO) O35185 (/ISO) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
2 | Q99PV5 (/TAS) Q99PV5 (/TAS) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
2 | O35185 (/ISO) O35185 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | Q99PV5 (/IPI) Q99PV5 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | O35185 (/ISO) O35185 (/ISO) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
2 | Q99PV5 (/IDA) Q99PV5 (/IDA) |
|
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
|
2 | Q99PV5 (/IDA) Q99PV5 (/IDA) |
|
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
|
2 | O35185 (/ISO) O35185 (/ISO) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
2 | O35185 (/ISO) O35185 (/ISO) |
|
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
|
2 | O35185 (/ISO) O35185 (/ISO) |
There are 40 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
11 |
O14503 (/IDA)
O14503 (/IDA)
O14503 (/IDA)
O14503 (/IDA)
O35185 (/IDA)
O35185 (/IDA)
Q0D311 (/IDA)
Q2PGD2 (/IDA)
Q6NY50 (/IDA)
Q99PV5 (/IDA)
(1 more) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
9 | O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) Q99PV5 (/IDA) Q99PV5 (/IDA) Q9C0J9 (/IDA) Q9C0J9 (/IDA) Q9C0J9 (/IDA) |
|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
9 | B3F209 (/ISS) O14503 (/ISS) O14503 (/ISS) O14503 (/ISS) O14503 (/ISS) O35780 (/ISS) Q5EA15 (/ISS) Q5EA15 (/ISS) Q5RAI7 (/ISS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
9 | B3F209 (/ISS) O35779 (/ISS) O35780 (/ISS) Q5EA15 (/ISS) Q5EA15 (/ISS) Q5RAI7 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) |
|
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
7 | B3F209 (/ISS) O35185 (/ISS) O35185 (/ISS) O35780 (/ISS) Q5EA15 (/ISS) Q5EA15 (/ISS) Q5RAI7 (/ISS) |
|
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
6 | O35185 (/IEP) O35185 (/IEP) O35779 (/IEP) O35780 (/IEP) Q99PV5 (/IEP) Q99PV5 (/IEP) |
|
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
6 | O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) Q0D311 (/IDA) Q6NY50 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
6 | O14503 (/IMP) O14503 (/IMP) O14503 (/IMP) O14503 (/IMP) O35185 (/IMP) O35185 (/IMP) |
|
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
5 | B3F209 (/ISS) O35780 (/ISS) Q5EA15 (/ISS) Q5EA15 (/ISS) Q5RAI7 (/ISS) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | O14503 (/NAS) O14503 (/NAS) O14503 (/NAS) O14503 (/NAS) |
|
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
4 | O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) |
|
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
4 | O35185 (/IMP) O35185 (/IMP) Q99PV5 (/IMP) Q99PV5 (/IMP) |
|
Entrainment of circadian clock by photoperiod GO:0043153
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
|
4 | O14503 (/ISS) O14503 (/ISS) O14503 (/ISS) O14503 (/ISS) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
4 | O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) |
|
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
3 | Q9C0J9 (/NAS) Q9C0J9 (/NAS) Q9C0J9 (/NAS) |
|
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
|
3 | O35185 (/IEP) O35185 (/IEP) O35780 (/IEP) |
|
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
|
3 | Q9C0J9 (/NAS) Q9C0J9 (/NAS) Q9C0J9 (/NAS) |
|
Negative regulation of myotube differentiation GO:0010832
Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
|
3 | Q9C0J9 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) |
|
Negative regulation of transcription by competitive promoter binding GO:0010944
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site.
|
3 | Q9C0J9 (/ISS) Q9C0J9 (/ISS) Q9C0J9 (/ISS) |
|
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
|
3 | Q9C0J9 (/NAS) Q9C0J9 (/NAS) Q9C0J9 (/NAS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | O35185 (/ISO) O35185 (/ISO) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q99PV5 (/TAS) Q99PV5 (/TAS) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q0D311 (/IDA) Q6NY50 (/IDA) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
2 | O35779 (/NAS) O35780 (/NAS) |
|
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
2 | O35185 (/ISO) O35185 (/ISO) |
|
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
|
2 | O35185 (/ISO) O35185 (/ISO) |
|
Negative regulation of myotube differentiation GO:0010832
Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
|
2 | Q99PV5 (/IDA) Q99PV5 (/IDA) |
|
Negative regulation of transcription by competitive promoter binding GO:0010944
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site.
|
2 | Q99PV5 (/IDA) Q99PV5 (/IDA) |
|
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
2 | O35185 (/ISO) O35185 (/ISO) |
|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
2 | O35185 (/IMP) O35185 (/IMP) |
|
Entrainment of circadian clock by photoperiod GO:0043153
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
|
2 | O35185 (/IMP) O35185 (/IMP) |
|
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
2 | O35185 (/ISO) O35185 (/ISO) |
|
Locomotor rhythm GO:0045475
The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
|
2 | Q0D311 (/IMP) Q6NY50 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | O35185 (/ISO) O35185 (/ISO) |
|
Regulation of neuronal synaptic plasticity GO:0048168
A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
2 | O35779 (/IEP) O35780 (/IEP) |
|
Regulation of neuronal synaptic plasticity GO:0048168
A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
2 | O35779 (/NAS) O35780 (/NAS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | O35780 (/IMP) |
|
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
|
1 | Q2PGD2 (/IDA) |
|
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
|
1 | O35780 (/IDA) |
|
Sleep GO:0030431
Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.
|
1 | Q2PGD2 (/IMP) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
8 | O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) Q6IB83 (/IDA) Q6IB83 (/IDA) Q6IB83 (/IDA) Q6IB83 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) O14503 (/IDA) O35185 (/IDA) O35185 (/IDA) O35780 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | B3F209 (/ISS) Q5EA15 (/ISS) Q5EA15 (/ISS) Q5RAI7 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | O14503 (/NAS) O14503 (/NAS) O14503 (/NAS) O14503 (/NAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | O35185 (/TAS) O35185 (/TAS) Q99PV5 (/TAS) Q99PV5 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | O35185 (/ISO) O35185 (/ISO) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
2 | O35185 (/ISO) O35185 (/ISO) |
|
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
|
2 | Q99PV5 (/TAS) Q99PV5 (/TAS) |