The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Helix-loop-helix DNA-binding domain
".
FunFam 2: Basic helix-loop-helix transcription factor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
18 |
F4IQH8 (/ISS)
Q0JXE7 (/ISS)
Q6NKN9 (/ISS)
Q8GY61 (/ISS)
Q8GY61 (/ISS)
Q93VJ4 (/ISS)
Q93VJ4 (/ISS)
Q93W88 (/ISS)
Q93W88 (/ISS)
Q9C670 (/ISS)
(8 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
15 |
F4IQH8 (/IPI)
Q6NKN9 (/IPI)
Q8GY61 (/IPI)
Q8GY61 (/IPI)
Q93VJ4 (/IPI)
Q93VJ4 (/IPI)
Q93W88 (/IPI)
Q93W88 (/IPI)
Q9C670 (/IPI)
Q9C670 (/IPI)
(5 more) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
4 | Q8GY61 (/IDA) Q8GY61 (/IDA) Q93VJ4 (/IDA) Q93VJ4 (/IDA) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
3 | Q9CAA9 (/IPI) Q9LV17 (/IPI) Q9LV17 (/IPI) |
|
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
3 | F4IQH8 (/IPI) Q9LK48 (/IPI) Q9LK48 (/IPI) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
2 | Q8GY61 (/IDA) Q8GY61 (/IDA) |
|
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
|
1 | F4IQH8 (/IDA) |
There are 13 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
14 |
F4IQH8 (/TAS)
Q0JXE7 (/TAS)
Q6NKN9 (/TAS)
Q93VJ4 (/TAS)
Q93VJ4 (/TAS)
Q9C670 (/TAS)
Q9C670 (/TAS)
Q9CAA9 (/TAS)
Q9FJL4 (/TAS)
Q9LK48 (/TAS)
(4 more) |
|
Response to blue light GO:0009637
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm.
|
6 | Q6NKN9 (/IDA) Q8GY61 (/IDA) Q8GY61 (/IDA) Q9C670 (/IDA) Q9C670 (/IDA) Q9FJL4 (/IDA) |
|
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
|
2 | Q8GY61 (/IDA) Q8GY61 (/IDA) |
|
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
|
2 | Q93VJ4 (/IMP) Q93VJ4 (/IMP) |
|
Response to blue light GO:0009637
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm.
|
2 | Q8GY61 (/IEP) Q8GY61 (/IEP) |
|
Response to gibberellin GO:0009739
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus.
|
2 | Q93W88 (/IEP) Q93W88 (/IEP) |
|
Positive regulation of flower development GO:0009911
Any process that activates or increases the frequency, rate or extent of flower development.
|
2 | Q9C670 (/IGI) Q9C670 (/IGI) |
|
Positive regulation of flower development GO:0009911
Any process that activates or increases the frequency, rate or extent of flower development.
|
2 | Q8GY61 (/IMP) Q8GY61 (/IMP) |
|
MRNA transcription GO:0009299
The cellular synthesis of messenger RNA (mRNA) from a DNA template.
|
1 | F4IQH8 (/IDA) |
|
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
1 | F4IQH8 (/IMP) |
|
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
|
1 | F4IQH8 (/IEP) |
|
Unidimensional cell growth GO:0009826
The process in which a cell irreversibly increases in size in one
|
1 | F4IQH8 (/IMP) |
|
Petal morphogenesis GO:0048446
The process in which the anatomical structures of the petal are generated and organized.
|
1 | Q0JXE7 (/IMP) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | Q6NKN9 (/IDA) Q8GY61 (/IDA) Q8GY61 (/IDA) Q9FJL4 (/IDA) |
