The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Helix-loop-helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18: Aryl hydrocarbon receptor nuclear translocator-lik...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 38 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
19 A0A0R4IH97 (/IPI) A0A0R4IR76 (/IPI) A0A2R8RSG0 (/IPI) A1A5T9 (/IPI) A4IG25 (/IPI) E7F4H0 (/IPI) F1Q584 (/IPI) O00327 (/IPI) O00327 (/IPI) O00327 (/IPI)
(9 more)
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
11 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS)
(1 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
10 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q9EPW1 (/ISS)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
10 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q9EPW1 (/ISS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
9 O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q6YGZ5 (/ISS) Q6YGZ5 (/ISS) Q6YGZ5 (/ISS) Q91YA9 (/ISS) Q9EPW1 (/ISS) Q9I8T7 (/ISS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
7 O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O61734 (/IDA) Q9WTL8 (/IDA)
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
7 O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) Q8WYA1 (/IDA) Q9WTL8 (/IDA)
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
7 A0MLS5 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q8QGQ7 (/ISS) Q91YA9 (/ISS) Q9EPW1 (/ISS)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
6 O00327 (/ISA) O00327 (/ISA) O00327 (/ISA) O00327 (/ISA) O00327 (/ISA) Q8WYA1 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
6 O00327 (/ISM) O00327 (/ISM) O00327 (/ISM) O00327 (/ISM) O00327 (/ISM) Q8WYA1 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
6 O00327 (/NAS) O00327 (/NAS) O00327 (/NAS) O00327 (/NAS) O00327 (/NAS) Q8WYA1 (/NAS)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
5 O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
5 O00327 (/IGI) O00327 (/IGI) O00327 (/IGI) O00327 (/IGI) O00327 (/IGI)
Aryl hydrocarbon receptor binding GO:0017162
Interacting selectively and non-covalently with an aryl hydrocarbon receptor.
5 O00327 (/IPI) O00327 (/IPI) O00327 (/IPI) O00327 (/IPI) O00327 (/IPI)
Hsp90 protein binding GO:0051879
Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.
5 O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA)
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
5 O00327 (/IPI) O00327 (/IPI) O00327 (/IPI) O00327 (/IPI) O00327 (/IPI)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
4 A4IG25 (/IDA) E7F4H0 (/IDA) F1Q584 (/IDA) Q8JIG1 (/IDA)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
2 Q7ZU37 (/IPI) Q9I879 (/IPI)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
2 Q8WYA1 (/IDA) Q9WTL8 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 Q8WYA1 (/IDA) Q9WTL8 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 Q8WYA1 (/IDA) Q9WTL8 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 O61734 (/IPI) Q9WTL8 (/IPI)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 Q9WTL8 (/IDA)
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
1 Q9WTL8 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q9WTL8 (/IC)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q9WTL8 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q9WTL8 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q9WTL8 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q9WTL8 (/ISA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q8WYA1 (/NAS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 Q9WTL8 (/ISA)
Aryl hydrocarbon receptor binding GO:0017162
Interacting selectively and non-covalently with an aryl hydrocarbon receptor.
1 Q9WTL8 (/ISO)
BHLH transcription factor binding GO:0043425
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.
1 Q9WTL8 (/IPI)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q9WTL8 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 O61734 (/NAS)
Hsp90 protein binding GO:0051879
Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.
1 Q9WTL8 (/ISO)
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
1 Q9WTL8 (/ISO)
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
1 Q9WTL8 (/ISO)

There are 89 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of circadian rhythm GO:0042753
Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.
13 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q8QGQ7 (/ISS)
(3 more)
Photoperiodism GO:0009648
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species.
12 A0A0R4IH97 (/IEP) A0A0R4IR76 (/IEP) A0A2R8RSG0 (/IEP) A1A5T9 (/IEP) A4IG25 (/IEP) E7F4H0 (/IEP) F1Q584 (/IEP) Q6NZ12 (/IEP) Q7ZU37 (/IEP) Q8JIG1 (/IEP)
(2 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
11 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS)
(1 more)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
11 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS)
(1 more)
Negative regulation of TOR signaling GO:0032007
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
11 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS)
(1 more)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
11 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS)
(1 more)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
11 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS)
(1 more)
Negative regulation of fat cell differentiation GO:0045599
Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.
11 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS)
(1 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
11 A0MLS5 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q6YGZ5 (/ISS) Q6YGZ5 (/ISS) Q6YGZ5 (/ISS) Q8QGQ7 (/ISS) Q91YA9 (/ISS) Q9EPW1 (/ISS)
(1 more)
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
11 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS)
(1 more)
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
11 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS)
(1 more)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
11 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS)
(1 more)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
11 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS)
(1 more)
Oxidative stress-induced premature senescence GO:0090403
A cellular senescence process associated with the dismantling of a cell as a response to oxidative stress, e.g. high levels of reactive oxygen species, such as superoxide anions, hydrogen peroxide, and hydroxyl radicals.
11 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS)
(1 more)
Positive regulation of protein acetylation GO:1901985
Any process that activates or increases the frequency, rate or extent of protein acetylation.
11 A0MLS5 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q6YGZ5 (/ISS) Q6YGZ5 (/ISS) Q6YGZ5 (/ISS) Q91YA9 (/ISS) Q9EPW1 (/ISS) Q9I8T7 (/ISS)
(1 more)
Regulation of type B pancreatic cell development GO:2000074
Any process that modulates the frequency, rate or extent of pancreatic B cell development.
11 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS)
(1 more)
Regulation of cellular senescence GO:2000772
Any process that modulates the frequency, rate or extent of cellular senescence.
11 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS)
(1 more)
Positive regulation of skeletal muscle cell differentiation GO:2001016
Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation.
11 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS)
(1 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
10 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q9EPW1 (/ISS)
Negative regulation of glucocorticoid receptor signaling pathway GO:2000323
Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway.
10 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q9EPW1 (/ISS)
Response to redox state GO:0051775
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important.
9 O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q6YGZ5 (/ISS) Q6YGZ5 (/ISS) Q6YGZ5 (/ISS) Q91YA9 (/ISS) Q9EPW1 (/ISS) Q9I8T7 (/ISS)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
8 A0A0R4IH97 (/IGI) A0A0R4IR76 (/IGI) A0A2R8RSG0 (/IGI) A1A5T9 (/IGI) Q6NZ12 (/IGI) Q7ZU37 (/IGI) Q9I879 (/IGI) Q9IAU1 (/IGI)
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
8 A0A0R4IH97 (/IGI) A0A0R4IR76 (/IGI) A0A2R8RSG0 (/IGI) A1A5T9 (/IGI) Q6NZ12 (/IGI) Q7ZU37 (/IGI) Q9I879 (/IGI) Q9IAU1 (/IGI)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
8 O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) Q8WYA1 (/IDA) Q9EPW1 (/IDA) Q9WTL8 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
8 O00327 (/IMP) O00327 (/IMP) O00327 (/IMP) O00327 (/IMP) O00327 (/IMP) Q7ZU37 (/IMP) Q9I879 (/IMP) Q9WTL8 (/IMP)
Regulation of hair cycle GO:0042634
Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.
7 A0MLS5 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS) Q9EPW1 (/ISS) Q9WTL8 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
7 O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) Q8WYA1 (/IDA) Q9WTL8 (/IDA)
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
7 D3ZT62 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) Q9EPW1 (/ISS)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
6 O00327 (/TAS) O00327 (/TAS) O00327 (/TAS) O00327 (/TAS) O00327 (/TAS) O61734 (/TAS)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
6 O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) Q9WTL8 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
6 O00327 (/IGI) O00327 (/IGI) O00327 (/IGI) O00327 (/IGI) O00327 (/IGI) Q9WTL8 (/IGI)
Response to redox state GO:0051775
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important.
6 O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) Q9WTL8 (/IDA)
Positive regulation of protein acetylation GO:1901985
Any process that activates or increases the frequency, rate or extent of protein acetylation.
6 O00327 (/IMP) O00327 (/IMP) O00327 (/IMP) O00327 (/IMP) O00327 (/IMP) Q9WTL8 (/IMP)
Regulation of hair cycle GO:0042634
Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.
5 O00327 (/IMP) O00327 (/IMP) O00327 (/IMP) O00327 (/IMP) O00327 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
4 A4IG25 (/IGI) E7F4H0 (/IGI) F1Q584 (/IGI) Q8JIG1 (/IGI)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
4 A4IG25 (/IGI) E7F4H0 (/IGI) F1Q584 (/IGI) Q8JIG1 (/IGI)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
3 Q8WYA1 (/IDA) Q9I8T7 (/IDA) Q9WTL8 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
3 Q7ZU37 (/IDA) Q9I879 (/IDA) Q9WTL8 (/IDA)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
2 Q9EPW1 (/IEP) Q9WTL8 (/IEP)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
2 O61734 (/IMP) Q9WTL8 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 Q7ZU37 (/IGI) Q9I879 (/IGI)
Regulation of vasculature development GO:1901342
Any process that modulates the frequency, rate or extent of vasculature development.
2 Q7ZU37 (/IGI) Q9I879 (/IGI)
Regulation of vasculature development GO:1901342
Any process that modulates the frequency, rate or extent of vasculature development.
2 Q7ZU37 (/IMP) Q9I879 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 O61734 (/NAS)
Circadian regulation of heart rate GO:0003053
Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours.
1 O61734 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9WTL8 (/IDA)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8WYA1 (/NAS)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q8WYA1 (/IDA)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
1 Q9WTL8 (/IDA)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q9WTL8 (/IMP)
Rhythmic behavior GO:0007622
The specific behavior of an organism that recur with measured regularity.
1 O61734 (/TAS)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 Q9WTL8 (/IMP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 O61734 (/NAS)
Eclosion rhythm GO:0008062
The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn.
1 O61734 (/NAS)
Eclosion rhythm GO:0008062
The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn.
1 O61734 (/TAS)
Entrainment of circadian clock GO:0009649
The synchronization of a circadian rhythm to environmental time cues such as light.
1 Q8WYA1 (/NAS)
Negative regulation of TOR signaling GO:0032007
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
1 Q9WTL8 (/IMP)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
1 Q9WTL8 (/ISO)
Regulation of protein catabolic process GO:0042176
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
1 Q9WTL8 (/IDA)
Response to starvation GO:0042594
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
1 O61734 (/IDA)
Regulation of hair cycle GO:0042634
Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.
1 Q9WTL8 (/ISO)
Positive regulation of circadian rhythm GO:0042753
Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.
1 Q9WTL8 (/IMP)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 Q9WTL8 (/IMP)
Regulation of circadian sleep/wake cycle, sleep GO:0045187
Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
1 O61734 (/IMP)
Regulation of circadian sleep/wake cycle, sleep GO:0045187
Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
1 O61734 (/TAS)
Locomotor rhythm GO:0045475
The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
1 O61734 (/NAS)
Locomotor rhythm GO:0045475
The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
1 O61734 (/TAS)
Negative regulation of fat cell differentiation GO:0045599
Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.
1 Q9WTL8 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9WTL8 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 O61734 (/NAS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 O61734 (/TAS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q9WTL8 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 O61734 (/NAS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 O61734 (/TAS)
Behavioral response to cocaine GO:0048148
Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus.
1 O61734 (/NAS)
Behavioral response to cocaine GO:0048148
Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus.
1 O61734 (/TAS)
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
1 Q9WTL8 (/IMP)
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
1 Q9WTL8 (/IMP)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 Q9WTL8 (/IMP)
Response to redox state GO:0051775
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important.
1 Q9WTL8 (/ISO)
Maternal process involved in parturition GO:0060137
A reproductive process occurring in the mother that results in birth.
1 Q9WTL8 (/IMP)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 Q9WTL8 (/IMP)
Oxidative stress-induced premature senescence GO:0090403
A cellular senescence process associated with the dismantling of a cell as a response to oxidative stress, e.g. high levels of reactive oxygen species, such as superoxide anions, hydrogen peroxide, and hydroxyl radicals.
1 Q9WTL8 (/IMP)
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
1 Q9WTL8 (/IMP)
Positive regulation of protein acetylation GO:1901985
Any process that activates or increases the frequency, rate or extent of protein acetylation.
1 Q9WTL8 (/ISO)
Regulation of type B pancreatic cell development GO:2000074
Any process that modulates the frequency, rate or extent of pancreatic B cell development.
1 Q9WTL8 (/IMP)
Negative regulation of glucocorticoid receptor signaling pathway GO:2000323
Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway.
1 Q9WTL8 (/IMP)
Regulation of cellular senescence GO:2000772
Any process that modulates the frequency, rate or extent of cellular senescence.
1 Q9WTL8 (/IMP)
Positive regulation of skeletal muscle cell differentiation GO:2001016
Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation.
1 Q9WTL8 (/IMP)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chromatoid body GO:0033391
A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
11 A0MLS5 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O00327 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS)
(1 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 H0Y5R1 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) Q8WYA1 (/IDA) Q9EPW1 (/IDA) Q9WTL8 (/IDA)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
9 A4IG25 (/IPI) E7F4H0 (/IPI) F1Q584 (/IPI) O00327 (/IPI) O00327 (/IPI) O00327 (/IPI) O00327 (/IPI) O00327 (/IPI) Q8JIG1 (/IPI)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
8 A0A140VKD3 (/IDA) A0A140VKD3 (/IDA) A0A140VKD3 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
8 A0A140VKD3 (/IDA) A0A140VKD3 (/IDA) A0A140VKD3 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA) O00327 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
7 O00327 (/TAS) O00327 (/TAS) O00327 (/TAS) O00327 (/TAS) O00327 (/TAS) O61734 (/TAS) Q9WTL8 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 A0MLS5 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS) Q9EPW1 (/ISS)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
6 A0MLS5 (/ISS) O88529 (/ISS) O88529 (/ISS) Q5R4T2 (/ISS) Q91YA9 (/ISS) Q9EPW1 (/ISS)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
4 A4IG25 (/IDA) E7F4H0 (/IDA) F1Q584 (/IDA) Q8JIG1 (/IDA)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
3 Q7ZU37 (/IDA) Q9I879 (/IDA) Q9WTL8 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O61734 (/NAS) Q8WYA1 (/NAS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 H0Y5R1 (/IDA) Q8WYA1 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9WTL8 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9WTL8 (/ISO)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
1 Q9WTL8 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9WTL8 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9WTL8 (/TAS)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q9WTL8 (/IDA)
Chromatoid body GO:0033391
A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
1 Q9WTL8 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q9WTL8 (/ISO)
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