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CATH Superfamily 3.90.79.10

Nucleoside Triphosphate Pyrophosphohydrolase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Nucleoside Triphosphate Pyrophosphohydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: ADP-sugar pyrophosphatase isoform X1

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
ADP-ribose diphosphatase. [EC: 3.6.1.13]
ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate.
    		 23 A0A2J8VKE2 A0A2J8VKE2 C7GUK9 C7GUK9 C7GUK9 C7GUK9 G2W9B6 G2W9B6 G2W9B6 G2W9B6
    (13 more...)
    8-oxo-dGDP phosphatase. [EC: 3.6.1.58]
    8-oxo-dGDP + H(2)O = 8-oxo-dGMP + phosphate.
    • The enzyme catalyzes the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP thereby preventing translational errors caused by oxidative damage.
    • The preferred in vivo substrate is not known.
    • The enzyme does not degrade 8-oxo-dGTP and 8-oxo-GTP to the monophosphates (cf. EC 3.6.1.55).
    • Ribonucleotide diphosphates and deoxyribonucleotide diphosphates are hydrolyzed with broad specificity.
    • The bifunctional enzyme NUDT5 also hydrolyzes ADP-ribose to AMP and D-ribose 5-phosphate (cf. EC 3.6.1.13).
    • The human enzyme NUDT18 also hydrolyzes 8-oxo-dADP and 2-hydroxy- dADP, the latter at a slower rate.
    		 7 A0A2J8VKE2 A0A2J8VKE2 Q5RCY2 Q5RCY2 Q6AY63 Q9JKX6 Q9UKK9
    ADP-D-ribose pyrophosphorylase. [EC: 2.7.7.96]
    ATP + D-ribose 5-phosphate = diphosphate + ADP-D-ribose.
    • The human enzyme produces ATP in nuclei in situations of high energy demand, such as chromatin remodeling.
    • The reaction is dependent on the presence of diphosphate.
    • In its absence the enzyme catalyzes the reaction of EC 3.6.1.13.
    • Cf. EC 2.7.7.35.
    		 7 A0A2J8VKE2 A0A2J8VKE2 Q5RCY2 Q5RCY2 Q6AY63 Q9JKX6 Q9UKK9
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