The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Cysteine proteinases
".
FunFam 7: Probable ubiquitin carboxyl-terminal hydrolase FAF...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 17 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | P55824 (/IPI) P70398 (/IPI) Q93008 (/IPI) Q93008 (/IPI) Q93008 (/IPI) |
Cysteine-type peptidase activity GO:0008234
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
|
4 | O00507 (/TAS) Q93008 (/TAS) Q93008 (/TAS) Q93008 (/TAS) |
Cysteine-type endopeptidase activity GO:0004197
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
|
3 | Q93008 (/TAS) Q93008 (/TAS) Q93008 (/TAS) |
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
|
3 | Q93008 (/EXP) Q93008 (/EXP) Q93008 (/EXP) |
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
|
3 | Q93008 (/TAS) Q93008 (/TAS) Q93008 (/TAS) |
Co-SMAD binding GO:0070410
Interacting selectively and non-covalently with a common mediator SMAD signaling protein.
|
3 | Q93008 (/IPI) Q93008 (/IPI) Q93008 (/IPI) |
Ubiquitinyl hydrolase activity GO:0101005
Catalysis of the hydrolysis of ubiquitin from proteins and other molecules.
|
3 | Q93008 (/ISS) Q93008 (/ISS) Q93008 (/ISS) |
Lys48-specific deubiquitinase activity GO:1990380
Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein.
|
3 | Q93008 (/IDA) Q93008 (/IDA) Q93008 (/IDA) |
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
|
2 | O00507 (/TAS) P55824 (/TAS) |
Co-SMAD binding GO:0070410
Interacting selectively and non-covalently with a common mediator SMAD signaling protein.
|
2 | O00507 (/ISS) P70398 (/ISS) |
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
|
1 | P55824 (/IDA) |
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | P70398 (/IPI) |
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
|
1 | P70398 (/ISO) |
Co-SMAD binding GO:0070410
Interacting selectively and non-covalently with a common mediator SMAD signaling protein.
|
1 | P70398 (/ISO) |
Ubiquitinyl hydrolase activity GO:0101005
Catalysis of the hydrolysis of ubiquitin from proteins and other molecules.
|
1 | P70398 (/IDA) |
Lys48-specific deubiquitinase activity GO:1990380
Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein.
|
1 | P70398 (/ISO) |
Lys48-specific deubiquitinase activity GO:1990380
Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein.
|
1 | P70398 (/ISS) |
There are 51 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
|
5 | O00507 (/ISS) P70398 (/ISS) Q93008 (/ISS) Q93008 (/ISS) Q93008 (/ISS) |
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
4 | P70398 (/IMP) Q93008 (/IMP) Q93008 (/IMP) Q93008 (/IMP) |
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
|
4 | P55824 (/IDA) Q93008 (/IDA) Q93008 (/IDA) Q93008 (/IDA) |
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
|
4 | P55824 (/TAS) Q93008 (/TAS) Q93008 (/TAS) Q93008 (/TAS) |
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
|
4 | P70398 (/IMP) Q93008 (/IMP) Q93008 (/IMP) Q93008 (/IMP) |
Protein deubiquitination involved in ubiquitin-dependent protein catabolic process GO:0071947
The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism.
|
4 | P70398 (/IMP) Q93008 (/IMP) Q93008 (/IMP) Q93008 (/IMP) |
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | Q93008 (/TAS) Q93008 (/TAS) Q93008 (/TAS) |
Protein targeting to peroxisome GO:0006625
The process of directing proteins towards the peroxisome, usually using signals contained within the protein.
|
3 | Q93008 (/TAS) Q93008 (/TAS) Q93008 (/TAS) |
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | Q93008 (/IMP) Q93008 (/IMP) Q93008 (/IMP) |
Female gamete generation GO:0007292
Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.
|
3 | Q93008 (/TAS) Q93008 (/TAS) Q93008 (/TAS) |
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
3 | Q93008 (/TAS) Q93008 (/TAS) Q93008 (/TAS) |
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | Q93008 (/IDA) Q93008 (/IDA) Q93008 (/IDA) |
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
3 | Q93008 (/IMP) Q93008 (/IMP) Q93008 (/IMP) |
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
|
3 | Q93008 (/TAS) Q93008 (/TAS) Q93008 (/TAS) |
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
3 | Q93008 (/IMP) Q93008 (/IMP) Q93008 (/IMP) |
Positive regulation of DNA demethylation GO:1901537
Any process that activates or increases the frequency, rate or extent of DNA demethylation.
|
3 | Q93008 (/IDA) Q93008 (/IDA) Q93008 (/IDA) |
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | O00507 (/ISS) P70398 (/ISS) |
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
|
2 | P55824 (/IMP) P70398 (/IMP) |
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | O00507 (/ISS) P70398 (/ISS) |
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
|
1 | P70398 (/IGI) |
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
1 | P70398 (/ISO) |
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
1 | P55824 (/IGI) |
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
|
1 | P55824 (/NAS) |
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P70398 (/ISO) |
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
1 | O00507 (/TAS) |
Cellularization GO:0007349
The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development.
|
1 | P55824 (/IMP) |
Germ cell migration GO:0008354
The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.
|
1 | P55824 (/TAS) |
Mystery cell differentiation GO:0008583
The process in which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster.
|
1 | P55824 (/IMP) |
Mystery cell differentiation GO:0008583
The process in which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster.
|
1 | P55824 (/TAS) |
Post-embryonic development GO:0009791
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
|
1 | P70398 (/IMP) |
Dorsal/ventral axis specification GO:0009950
The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
1 | P55824 (/IGI) |
Dorsal/ventral axis specification GO:0009950
The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
|
1 | P55824 (/IMP) |
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
|
1 | P70398 (/ISO) |
Cerebellar cortex structural organization GO:0021698
The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
|
1 | P70398 (/IMP) |
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
|
1 | P70398 (/IMP) |
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P70398 (/ISO) |
Nuclear cortical migration GO:0035192
The symmetric outward movement of the syncytial nuclei from their positions in the ellipsoid toward the periphery of the embryo, during mitotic cycles 8 and 9. This movement results in the placement of nuclei in a uniform monolayer at the cortex of the developing embryo.
|
1 | P55824 (/IMP) |
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
1 | P70398 (/ISO) |
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
1 | P70398 (/ISS) |
Negative regulation of innate immune response GO:0045824
Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
|
1 | P55824 (/HMP) |
Negative regulation of proteolysis GO:0045861
Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
|
1 | P55824 (/NAS) |
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
|
1 | P70398 (/ISO) |
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
1 | P70398 (/ISO) |
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
1 | P70398 (/ISS) |
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
|
1 | P55824 (/HMP) |
Regulation of T cell receptor signaling pathway GO:0050856
Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
|
1 | P70398 (/ISO) |
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
|
1 | P70398 (/IMP) |
Protein deubiquitination involved in ubiquitin-dependent protein catabolic process GO:0071947
The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism.
|
1 | P70398 (/ISO) |
Positive regulation of DNA demethylation GO:1901537
Any process that activates or increases the frequency, rate or extent of DNA demethylation.
|
1 | P70398 (/ISO) |
Positive regulation of DNA demethylation GO:1901537
Any process that activates or increases the frequency, rate or extent of DNA demethylation.
|
1 | P70398 (/ISS) |
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | P70398 (/IGI) |
There are 11 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
5 | P55824 (/IDA) P70398 (/IDA) Q93008 (/IDA) Q93008 (/IDA) Q93008 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | Q93008 (/IDA) Q93008 (/IDA) Q93008 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | Q93008 (/TAS) Q93008 (/TAS) Q93008 (/TAS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
3 | Q93008 (/HDA) Q93008 (/HDA) Q93008 (/HDA) |
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
|
3 | Q93008 (/IDA) Q93008 (/IDA) Q93008 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | O00507 (/ISS) P70398 (/ISS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P70398 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P70398 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P70398 (/ISS) |
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
|
1 | P70398 (/ISO) |
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
|
1 | P70398 (/IDA) |