The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 60: Cathepsin Z

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Carboxypeptidase activity GO:0004180
Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide.
3 Q9UBR2 (/IMP) Q9UBR2 (/IMP) Q9UBR2 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q9UBR2 (/IPI) Q9UBR2 (/IPI) Q9UBR2 (/IPI)
Cysteine-type peptidase activity GO:0008234
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
3 Q9UBR2 (/TAS) Q9UBR2 (/TAS) Q9UBR2 (/TAS)
Carboxypeptidase activity GO:0004180
Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide.
2 Q9WUU7 (/ISO) Q9WUU7 (/ISO)
Cysteine-type endopeptidase activity GO:0004197
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
1 Q9R1T3 (/TAS)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Angiotensin maturation GO:0002003
The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood.
3 Q9UBR2 (/TAS) Q9UBR2 (/TAS) Q9UBR2 (/TAS)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
3 Q9UBR2 (/IMP) Q9UBR2 (/IMP) Q9UBR2 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
3 Q9UBR2 (/TAS) Q9UBR2 (/TAS) Q9UBR2 (/TAS)
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
3 Q9UBR2 (/TAS) Q9UBR2 (/TAS) Q9UBR2 (/TAS)
Negative regulation of plasminogen activation GO:0010757
Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.
3 Q9UBR2 (/IMP) Q9UBR2 (/IMP) Q9UBR2 (/IMP)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
3 Q9UBR2 (/IDA) Q9UBR2 (/IDA) Q9UBR2 (/IDA)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
3 Q9UBR2 (/TAS) Q9UBR2 (/TAS) Q9UBR2 (/TAS)
COPII vesicle coating GO:0048208
The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.
3 Q9UBR2 (/TAS) Q9UBR2 (/TAS) Q9UBR2 (/TAS)
Regulation of neuron death GO:1901214
Any process that modulates the frequency, rate or extent of neuron death.
3 Q9UBR2 (/IGI) Q9UBR2 (/IGI) Q9UBR2 (/IGI)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
2 F1RDQ9 (/IMP) Q5XJD4 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
2 Q9WUU7 (/ISO) Q9WUU7 (/ISO)
Negative regulation of plasminogen activation GO:0010757
Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.
2 Q9WUU7 (/ISO) Q9WUU7 (/ISO)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
2 Q9WUU7 (/ISO) Q9WUU7 (/ISO)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
2 Q9WUU7 (/ISO) Q9WUU7 (/ISO)
Ecdysis, collagen and cuticulin-based cuticle GO:0042395
The shedding of the old collagen and cuticulin-based cuticle fragments during the molting cycle. Examples of this process are found in invertebrates.
2 G5EGP8 (/IMP) Q6PN98 (/IMP)
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
2 Q9WUU7 (/ISO) Q9WUU7 (/ISO)
Epithelial tube branching involved in lung morphogenesis GO:0060441
The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
2 Q9WUU7 (/IEP) Q9WUU7 (/IEP)
Regulation of neuron death GO:1901214
Any process that modulates the frequency, rate or extent of neuron death.
2 Q9WUU7 (/ISO) Q9WUU7 (/ISO)
Positive regulation of neural precursor cell proliferation GO:2000179
Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.
2 Q9WUU7 (/ISO) Q9WUU7 (/ISO)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
1 G5EGP8 (/IMP)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q9R1T3 (/IMP)
Gonad morphogenesis GO:0035262
The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.
1 G5EGP8 (/IMP)
Vulval development GO:0040025
The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
1 G5EGP8 (/IMP)
Post-embryonic body morphogenesis GO:0040032
The process in which the anatomical structures of the post-embryonic soma are generated and organized.
1 G5EGP8 (/IMP)
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
1 Q9R1T3 (/IMP)
Positive regulation of neural precursor cell proliferation GO:2000179
Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.
1 Q9R1T3 (/IMP)

There are 29 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
6 G5EGP8 (/IDA) Q6PN98 (/IDA) Q9R1T3 (/IDA) Q9UBR2 (/IDA) Q9UBR2 (/IDA) Q9UBR2 (/IDA)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
5 Q9UBR2 (/HDA) Q9UBR2 (/HDA) Q9UBR2 (/HDA) Q9WUU7 (/HDA) Q9WUU7 (/HDA)
Cell cortex region GO:0099738
The complete extent of cell cortex that underlies some some region of the plasma membrane
4 Q9R1T3 (/IDA) Q9UBR2 (/IDA) Q9UBR2 (/IDA) Q9UBR2 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 Q9UBR2 (/TAS) Q9UBR2 (/TAS) Q9UBR2 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 Q9UBR2 (/HDA) Q9UBR2 (/HDA) Q9UBR2 (/HDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
3 Q9UBR2 (/IDA) Q9UBR2 (/IDA) Q9UBR2 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
3 Q9UBR2 (/IDA) Q9UBR2 (/IDA) Q9UBR2 (/IDA)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
3 Q9UBR2 (/TAS) Q9UBR2 (/TAS) Q9UBR2 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q9UBR2 (/TAS) Q9UBR2 (/TAS) Q9UBR2 (/TAS)
COPII-coated ER to Golgi transport vesicle GO:0030134
A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport).
3 Q9UBR2 (/TAS) Q9UBR2 (/TAS) Q9UBR2 (/TAS)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
3 Q9UBR2 (/IDA) Q9UBR2 (/IDA) Q9UBR2 (/IDA)
Endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116
The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.
3 Q9UBR2 (/TAS) Q9UBR2 (/TAS) Q9UBR2 (/TAS)
Specific granule lumen GO:0035580
The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
3 Q9UBR2 (/TAS) Q9UBR2 (/TAS) Q9UBR2 (/TAS)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
3 Q9UBR2 (/IDA) Q9UBR2 (/IDA) Q9UBR2 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 Q9UBR2 (/HDA) Q9UBR2 (/HDA) Q9UBR2 (/HDA)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
3 Q9UBR2 (/TAS) Q9UBR2 (/TAS) Q9UBR2 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 Q9WUU7 (/ISO) Q9WUU7 (/ISO)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
2 Q9WUU7 (/ISO) Q9WUU7 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 Q9WUU7 (/ISO) Q9WUU7 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q9WUU7 (/ISO) Q9WUU7 (/ISO)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
2 Q9WUU7 (/ISO) Q9WUU7 (/ISO)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
2 Q9WUU7 (/ISO) Q9WUU7 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 Q9WUU7 (/ISO) Q9WUU7 (/ISO)
Cell cortex region GO:0099738
The complete extent of cell cortex that underlies some some region of the plasma membrane
2 Q9WUU7 (/ISO) Q9WUU7 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q9R1T3 (/IDA)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 Q9R1T3 (/IDA)
Yolk granule GO:0042718
Discrete structures that partition the water-insoluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed.
1 G5EGP8 (/IDA)
Collagen and cuticulin-based cuticle extracellular matrix GO:0060102
A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans.
1 G5EGP8 (/IDA)
Secretory vesicle GO:0099503
A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space.
1 Q6PN98 (/IDA)