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CATH Superfamily 3.90.70.10

Cysteine proteinases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Cathepsin S

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cathepsin L. [EC: 3.4.22.15]
Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
  • A lysosomal enzyme that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN(2) or the epoxide inhibitor E-64.
  • Belongs to peptidase family C1.
 40 A0A024R276 A0A024R276 A0A024R276 A0A024R276 A0A0D9R4W3 A0A0D9R4W3 A0A2R9ACG6 A0A2R9ACG6 A0A2R9ACG6 A0A2R9ACG6
(30 more...)
Cathepsin K. [EC: 3.4.22.38]
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
  • Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption.
  • Belongs to peptidase family C1.
 27 G7MDI3 G7MDI3 G7MDI3 G7MDI3 G8F4A4 G8F4A4 G8F4A4 G8F4A4 O35186 P43235
(17 more...)
Cathepsin S. [EC: 3.4.22.27]
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.
  • A lysosomal cysteine endopeptidase that is unusual among such enzymes for its stability to neutral pH.
  • Belongs to peptidase family C1.
 6 O70370 P25326 P25774 Q02765 Q8HY81 Q8HY82
Cathepsin V. [EC: 3.4.22.43]
The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val- Arg-NHMec).
  • Maximally active at pH 5.7 and unstable at neutral pH.
  • Compound E-64, leupeptin and chicken cystatin are inhibitors.
  • Belongs to peptidase family C1.
 5 A0A024R141 A0A024R141 O60911 O60911 Q5E998
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