The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Cysteine proteinases
".
FunFam 53: Ubiquitin carboxyl-terminal hydrolase 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
|
3 | Q29RP1 (/ISS) Q569C3 (/ISS) Q8BJQ2 (/ISS) |
|
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
|
3 | Q29RP1 (/ISS) Q569C3 (/ISS) Q8BJQ2 (/ISS) |
|
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
|
2 | O94782 (/TAS) Q5ZJE0 (/TAS) |
|
Cysteine-type endopeptidase activity GO:0004197
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
|
1 | O94782 (/TAS) |
|
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
|
1 | O94782 (/IDA) |
|
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
|
1 | O94782 (/IMP) |
|
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
|
1 | Q8BJQ2 (/ISO) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | O94782 (/IPI) |
|
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
|
1 | O94782 (/EXP) |
|
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
|
1 | Q8BJQ2 (/ISO) |
|
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
|
1 | O94782 (/IDA) |
|
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
|
1 | Q8BJQ2 (/ISO) |
There are 16 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of DNA repair GO:0006282
Any process that modulates the frequency, rate or extent of DNA repair.
|
3 | Q29RP1 (/ISS) Q569C3 (/ISS) Q8BJQ2 (/ISS) |
|
Response to UV GO:0009411
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
|
3 | Q29RP1 (/ISS) Q569C3 (/ISS) Q8BJQ2 (/ISS) |
|
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
|
3 | Q29RP1 (/ISS) Q569C3 (/ISS) Q8BJQ2 (/ISS) |
|
Monoubiquitinated protein deubiquitination GO:0035520
The removal of the ubiquitin group from a monoubiquitinated protein.
|
3 | Q29RP1 (/ISS) Q569C3 (/ISS) Q8BJQ2 (/ISS) |
|
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
|
1 | Q8BJQ2 (/IMP) |
|
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
1 | Q5ZJE0 (/TAS) |
|
Regulation of DNA repair GO:0006282
Any process that modulates the frequency, rate or extent of DNA repair.
|
1 | O94782 (/IDA) |
|
Regulation of DNA repair GO:0006282
Any process that modulates the frequency, rate or extent of DNA repair.
|
1 | Q8BJQ2 (/ISO) |
|
Response to UV GO:0009411
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
|
1 | O94782 (/IDA) |
|
Response to UV GO:0009411
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
|
1 | Q8BJQ2 (/ISO) |
|
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
|
1 | O94782 (/IDA) |
|
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
|
1 | Q8BJQ2 (/ISO) |
|
Monoubiquitinated protein deubiquitination GO:0035520
The removal of the ubiquitin group from a monoubiquitinated protein.
|
1 | O94782 (/IMP) |
|
Monoubiquitinated protein deubiquitination GO:0035520
The removal of the ubiquitin group from a monoubiquitinated protein.
|
1 | Q8BJQ2 (/ISO) |
|
Interstrand cross-link repair GO:0036297
Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.
|
1 | O94782 (/TAS) |
|
DNA damage response, detection of DNA damage GO:0042769
The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal.
|
1 | O94782 (/TAS) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | Q29RP1 (/ISS) Q569C3 (/ISS) Q8BJQ2 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | O94782 (/TAS) Q5ZJE0 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O94782 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q8BJQ2 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | O94782 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q8BJQ2 (/ISO) |
