The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Ubiquitin carboxyl-terminal hydrolase 46

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
83 A4FUN7 (/ISS) A5D9H7 (/ISS) A5D9H7 (/ISS) A5WWB0 (/ISS) C0HB46 (/ISS) C0HB46 (/ISS) P62069 (/ISS) P62069 (/ISS) P62069 (/ISS) P62069 (/ISS)
(73 more)
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
83 A4FUN7 (/ISS) A5D9H7 (/ISS) A5D9H7 (/ISS) A5WWB0 (/ISS) C0HB46 (/ISS) C0HB46 (/ISS) P62069 (/ISS) P62069 (/ISS) P62069 (/ISS) P62069 (/ISS)
(73 more)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
47 O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA)
(37 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
47 O75317 (/IPI) O75317 (/IPI) O75317 (/IPI) O75317 (/IPI) O75317 (/IPI) O75317 (/IPI) O75317 (/IPI) O75317 (/IPI) O75317 (/IPI) O75317 (/IPI)
(37 more)
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
47 O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA)
(37 more)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
38 P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO)
(28 more)
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
38 P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO)
(28 more)
Ubiquitinyl hydrolase activity GO:0101005
Catalysis of the hydrolysis of ubiquitin from proteins and other molecules.
38 P62069 (/IDA) P62069 (/IDA) P62069 (/IDA) P62069 (/IDA) P62069 (/IDA) P62069 (/IDA) P62069 (/IDA) P62069 (/IDA) P62069 (/IDA) P62069 (/IDA)
(28 more)
Ubiquitinyl hydrolase activity GO:0101005
Catalysis of the hydrolysis of ubiquitin from proteins and other molecules.
38 P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO)
(28 more)
Cysteine-type endopeptidase activity GO:0004197
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
10 O75317 (/IMP) O75317 (/IMP) O75317 (/IMP) O75317 (/IMP) O75317 (/IMP) O75317 (/IMP) O75317 (/IMP) O75317 (/IMP) O75317 (/IMP) O75317 (/IMP)
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
10 O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS)
Cysteine-type endopeptidase activity GO:0004197
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
8 A4FUN7 (/ISS) A5D9H7 (/ISS) A5D9H7 (/ISS) C0HB46 (/ISS) C0HB46 (/ISS) Q52KZ6 (/ISS) Q5M981 (/ISS) Q9D9M2 (/ISS)
Cysteine-type endopeptidase activity GO:0004197
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
1 Q9D9M2 (/ISO)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
85 O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA) O75317 (/IDA)
(75 more)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
83 A4FUN7 (/ISS) A5D9H7 (/ISS) A5D9H7 (/ISS) A5WWB0 (/ISS) C0HB46 (/ISS) C0HB46 (/ISS) P62069 (/ISS) P62069 (/ISS) P62069 (/ISS) P62069 (/ISS)
(73 more)
Regulation of synaptic transmission, GABAergic GO:0032228
Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
75 A5WWB0 (/ISS) P62068 (/ISS) P62068 (/ISS) P62068 (/ISS) P62068 (/ISS) P62068 (/ISS) P62068 (/ISS) P62068 (/ISS) P62068 (/ISS) P62068 (/ISS)
(65 more)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
38 P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO)
(28 more)
Positive regulation of T cell receptor signaling pathway GO:0050862
Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
38 P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO)
(28 more)
Behavioral fear response GO:0001662
An acute behavioral change resulting from a perceived external threat.
37 P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP)
(27 more)
Adult feeding behavior GO:0008343
Feeding behavior in a fully developed and mature organism.
37 P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP)
(27 more)
Regulation of synaptic transmission, GABAergic GO:0032228
Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
37 P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP)
(27 more)
Behavioral response to ethanol GO:0048149
Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
37 P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP)
(27 more)
Righting reflex GO:0060013
A reflex process in which an animal immediately tries to turn over after being placed in a supine position.
37 P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP) P62069 (/IMP)
(27 more)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
37 P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO)
(27 more)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
10 O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
1 F1M625 (/IDA)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
1 F1M625 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
38 P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO)
(28 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
38 P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO)
(28 more)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
37 P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO)
(27 more)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
37 P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO) P62069 (/ISO)
(27 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
10 O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS) O75317 (/TAS)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 F1M625 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 F1M625 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 F1M625 (/IMP)
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