The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cysteine proteinases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: Ubiquitin specific peptidase 10

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 21 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
9 A5PJS6 (/ISS) P52479 (/ISS) Q2NL57 (/ISS) Q2NL57 (/ISS) Q3KR59 (/ISS) Q5ZJN4 (/ISS) Q6DIJ4 (/ISS) Q7ZXR7 (/ISS) Q7ZXR7 (/ISS)
Cysteine-type endopeptidase activity GO:0004197
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
9 A5PJS6 (/ISS) P52479 (/ISS) Q2NL57 (/ISS) Q2NL57 (/ISS) Q3KR59 (/ISS) Q5ZJN4 (/ISS) Q6DIJ4 (/ISS) Q7ZXR7 (/ISS) Q7ZXR7 (/ISS)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
9 A5PJS6 (/ISS) P52479 (/ISS) Q2NL57 (/ISS) Q2NL57 (/ISS) Q3KR59 (/ISS) Q5ZJN4 (/ISS) Q6DIJ4 (/ISS) Q7ZXR7 (/ISS) Q7ZXR7 (/ISS)
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
9 A5PJS6 (/ISS) P52479 (/ISS) Q2NL57 (/ISS) Q2NL57 (/ISS) Q3KR59 (/ISS) Q5ZJN4 (/ISS) Q6DIJ4 (/ISS) Q7ZXR7 (/ISS) Q7ZXR7 (/ISS)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
9 A5PJS6 (/ISS) P52479 (/ISS) Q2NL57 (/ISS) Q2NL57 (/ISS) Q3KR59 (/ISS) Q5ZJN4 (/ISS) Q6DIJ4 (/ISS) Q7ZXR7 (/ISS) Q7ZXR7 (/ISS)
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
1 Q14694 (/IPI)
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
1 P52479 (/ISO)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q14694 (/HDA)
Cysteine-type endopeptidase activity GO:0004197
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
1 Q14694 (/IMP)
Cysteine-type endopeptidase activity GO:0004197
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
1 P52479 (/ISO)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
1 Q14694 (/IDA)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
1 Q14694 (/IMP)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
1 P52479 (/ISO)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
1 Q14694 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q14694 (/IPI)
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
1 Q14694 (/IDA)
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
1 Q14694 (/IMP)
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
1 P52479 (/ISO)
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
1 Q14694 (/TAS)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 Q14694 (/IDA)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 P52479 (/ISO)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
9 A5PJS6 (/ISS) P52479 (/ISS) Q2NL57 (/ISS) Q2NL57 (/ISS) Q3KR59 (/ISS) Q5ZJN4 (/ISS) Q6DIJ4 (/ISS) Q7ZXR7 (/ISS) Q7ZXR7 (/ISS)
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
9 A5PJS6 (/ISS) P52479 (/ISS) Q2NL57 (/ISS) Q2NL57 (/ISS) Q3KR59 (/ISS) Q5ZJN4 (/ISS) Q6DIJ4 (/ISS) Q7ZXR7 (/ISS) Q7ZXR7 (/ISS)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
9 A5PJS6 (/ISS) P52479 (/ISS) Q2NL57 (/ISS) Q2NL57 (/ISS) Q3KR59 (/ISS) Q5ZJN4 (/ISS) Q6DIJ4 (/ISS) Q7ZXR7 (/ISS) Q7ZXR7 (/ISS)
DNA damage response, signal transduction by p53 class mediator GO:0030330
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
9 A5PJS6 (/ISS) P52479 (/ISS) Q2NL57 (/ISS) Q2NL57 (/ISS) Q3KR59 (/ISS) Q5ZJN4 (/ISS) Q6DIJ4 (/ISS) Q7ZXR7 (/ISS) Q7ZXR7 (/ISS)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
9 A5PJS6 (/ISS) P52479 (/ISS) Q2NL57 (/ISS) Q2NL57 (/ISS) Q3KR59 (/ISS) Q5ZJN4 (/ISS) Q6DIJ4 (/ISS) Q7ZXR7 (/ISS) Q7ZXR7 (/ISS)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
9 A5PJS6 (/ISS) P52479 (/ISS) Q2NL57 (/ISS) Q2NL57 (/ISS) Q3KR59 (/ISS) Q5ZJN4 (/ISS) Q6DIJ4 (/ISS) Q7ZXR7 (/ISS) Q7ZXR7 (/ISS)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 Q14694 (/IMP)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 P52479 (/ISO)
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 Q14694 (/IDA)
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 P52479 (/ISO)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
1 Q14694 (/IDA)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
1 Q14694 (/IMP)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
1 P52479 (/ISO)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
1 Q14694 (/TAS)
Translesion synthesis GO:0019985
The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.
1 Q14694 (/TAS)
DNA damage response, signal transduction by p53 class mediator GO:0030330
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
1 Q14694 (/IMP)
DNA damage response, signal transduction by p53 class mediator GO:0030330
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
1 P52479 (/ISO)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
1 Q14694 (/IMP)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
1 P52479 (/ISO)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 Q14694 (/IMP)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 P52479 (/ISO)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 A5PJS6 (/ISS) P52479 (/ISS) Q2NL57 (/ISS) Q2NL57 (/ISS) Q3KR59 (/ISS) Q5ZJN4 (/ISS) Q6DIJ4 (/ISS) Q7ZXR7 (/ISS) Q7ZXR7 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 A5PJS6 (/ISS) P52479 (/ISS) Q2NL57 (/ISS) Q2NL57 (/ISS) Q3KR59 (/ISS) Q5ZJN4 (/ISS) Q6DIJ4 (/ISS) Q7ZXR7 (/ISS) Q7ZXR7 (/ISS)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
9 A5PJS6 (/ISS) P52479 (/ISS) Q2NL57 (/ISS) Q2NL57 (/ISS) Q3KR59 (/ISS) Q5ZJN4 (/ISS) Q6DIJ4 (/ISS) Q7ZXR7 (/ISS) Q7ZXR7 (/ISS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 A5PJS6 (/ISS) P52479 (/ISS) Q3KR59 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q14694 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P52479 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q14694 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P52479 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q14694 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q14694 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P52479 (/ISO)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
1 Q14694 (/IDA)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
1 P52479 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q14694 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P52479 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q14694 (/TAS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q14694 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P52479 (/ISO)
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